CAS: 693-04-9; Butylmagnesium Chloride

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CAS号109-69-3 1-氯丁烷 | CAS号7439-95-4 镁标准溶液 | CAS号86901-19-1 MAGNESIUMANTHRA... | CAS号60-29-7 乙醚 | CAS号4144-61-0 ethyl 6-oxodecanoate | CAS号37174-96-2 4-氧代辛酸乙酯 | CAS号3132-99-8 间溴苯甲醛 | CAS号583-03-9 1-苯基-1-戊醇 | CAS号57242-02-1 1-phenyl-2,2,3,... | CAS号5058-19-5 2-丁基吡啶 | CAS号5335-75-1 4-丁基吡啶 | CAS号37909-95-8 4-正丁基联苯 | CAS号34160-40-2 6-溴吡啶-2-甲醛 | CAS号3449-28-3 二正丁基二氯硅烷

氯丁烷置于magnesium体系中,用 氘代四氢呋喃 作为反应溶剂,80.0 °C,689.49 Kpa 条件下,以95%的收率获得产物正丁基氯化镁
参考文献:一次性弹药筒概念可按需合成turbo Grignards,Knochel-Hauser酰胺和烷氧基镁.
标题:一次性弹药筒概念可按需合成turbo Grignards,Knochel-Hauser酰胺和烷氧基镁.
摘要:镁有机金属试剂在有机合成中占据中心位置.这些化合物的新鲜度是实现高转化率和可再现结果的关键.由金属镁合成格氏试剂的常用方法存在安全性问题,并且批次间存在差异.固体试剂与溶液相试剂相结合的管状反应器可实现有机镁试剂的连续流制备.据报道,使用镁金属和氯化锂的分层填充床柱来合成高浓度涡轮格氏试剂.一种低成本的吊舱式合成器原型,其中包括一次性使用的预包装全氟化药筒和试剂袋,用于按需实验室规模自动合成碳,氮,并介绍了氧涡轮镁碱.该概念将使人们能够以发现规模获得新鲜的有机镁试剂,并且与操作者在流动和/或有机金属化学领域的经验无关.
DOI:10.3762/bjoc.16.115

专利信息

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-11434217-B2
优先权日:2017-12-29
标 题 :Method for synthesis of lobaric acid and analog thereof
发明人：YIM JOUNG HAN; KIM IL-CHAN; HAN SE JONG; YOUN UI JOUNG; LEE HONG KUM; LEE JUN HYUCK; KIM TAI KYOUNG; YEO KWON JOO
权利人:KOREA INST OCEAN SCI & TECH; KOREA INSTITUTE OF OCEAN SCIENCE AND TECH
摘要:The present invention can synthesize lobaric acid and four analogues thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, by a simple, economic and efficient chemical synthesis method.

专利号:US-10000432-B2
优先权日:2014-01-13
标 题 :Processes for the synthesis of chiral 1-alkanols
发明人：NEGISHI EI-ICHI
权利人:PURDUE RESEARCH FOUNDATION
摘要:The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.

专利号:US-2010312013-A1
优先权日:2009-06-03
标 题:Steroselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; YEE NATHAN K; SONG JINHUA J; REEVES JONATHAN T
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for synthesis of a compound of Formula (X) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl,n wherein each substituent group of R 1 is optionally independently substituted with one to three substituents selected from C 1 -C 3 alkyl, C 1 -C 3 alkoxy, phenyl, and alkoxyphenyl; and n n R 2 and R 3 are each independently C 1 -C 5 alkyl.

专利号:US-5502126-A
优先权日:1993-06-17
标 题 :Process for the synthesis of isoprene butadiene rubber
发明人：BELL ANTHONY J; MATRANA BARRY A; HALASA ADEL F
权利人:GOODYEAR TIRE & RUBBER
摘要:The subject invention relates to a technique for synthesizing rubbery non-tapered, random, copolymers of 1,3-butadiene and isoprene. These rubbery copolymers exhibit an excellent combination of properties for utilization in tire sidewall rubber compounds for truck tires. By utilizing these isoprene-butadiene rubbers in tire sidewalls, tires having improved cut growth resistance can be built without sacrificing rolling resistance. Such rubbers can also be employed in tire tread compounds to improve tread wear characteristics and decrease rolling resistance without sacrificing traction characteristics. This invention more specifically discloses a process for the synthesis of isoprene-butadiene rubbers which comprises copolymerizing isoprene monomer and 1,3-butadiene monomer in an organic solvent in the presence of a catalyst system which is made by the sequential steps of (1) mixing (a) an organoaluminum hydride, (b) a member selected from the group consisting of aliphatic alcohols, cycloaliphatic alcohols, aliphatic thiols, cycloaliphatic thiols, trialkyl silanols, and triaryl silanols, and (c) optionally, 1,3-butadiene in an organic solvent to produce a modified organoaluminum catalyst component; (2) adding an organometallic compound which contains a metal from Group III-B of the Periodic System to the modified organoaluminum catalyst component to produce a Group III-B metal containing catalyst component; and (3) adding a compound which contains at least one labile halogen atom to the Group III-B metal containing catalyst component.

专利号:US-11738092-B2
优先权日:2019-12-04
标题:Methods and compositions for synthesis of therapeutic nanoparticles
发明人：WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J
权利人:DANTARI INC
摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.