CAS: 98-19-1; 1-(Tert-Butyl)-3,5-Dimethylbenzene

该化合物是一种替代芳香化合物,其特点是一个基-丁基和两个基-苯环上的两组甲基组,其结构受到极大阻碍,因而能够增强稳定性,使其成为有机合成的中间体,特别是在生产特殊化学品,香料和农用化学品方面.二甲基苯组有助于增加亲脂性,而对称二甲基替代则允许在电光替代反应中有控制地再活动.这种化合物因其可预见的再活动性,热稳定性和与各种合成途径的兼容性而受到重视,通常在标准的实验室条件下处理,不需要对芳香烃采取专门防范措施.

结构式图片

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号108-38-3 间二甲苯 | CAS号75-65-0 叔丁醇 | CAS号556-96-7 5-溴间二甲苯 | CAS号677-22-5 叔丁基氯化镁 | CAS号115-11-7 2-甲基丙烯 | CAS号5345-05-1 2-溴-5-叔丁基-1,3-二甲苯 | CAS号57834-94-3 1-(2,4-dimethyl... | CAS号507-20-0 氯代叔丁烷 | CAS号75-28-5 异丁烷 | CAS号554-95-0 均苯三甲酸 | CAS号5122-20-3 5-叔丁基-2-碘-1,3-二甲基苯 | CAS号499-06-9 3,5-二甲基苯甲酸 | CAS号42014-60-8 4-叔丁基-2,6-二甲基-苯胺 | CAS号443-88-9 2-氟-1,3-二甲苯 | CAS号2040-10-0 4'-叔丁基-2',6'-二甲基乙酰苯 | CAS号19387-83-8 4-叔丁基-2,6-二甲基苄基氯 | CAS号65338-71-8 5-tert-butyl-2-... | CAS号81-14-1 酮麝香 | CAS号81-15-2 二甲苯麝香

合成工艺路线路线简述

    1-(2,4-二甲基苯基)-2-甲基丙烷置于三氯化铁体系中,化学反应生成 1-叔丁基-3,5-二甲苯
    参考文献:The Action Of Anhydrous Ferric Chloride On Alkylbenzenes1
    标题:The Action Of Anhydrous Ferric Chloride On Alkylbenzenes1
    摘要:
    DOI:10.1021/ja01846A061

    海关参考信息

    专利信息


    专利号:US-2003162992-A1
    优先权日:2001-12-14
    标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
    发明人:WATANABE KYOICHI A; DU JINFA
    摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

    专利号:US-6355826-B1
    优先权日:1997-09-17
    标题:Synthesis of stable nitrile oxide compounds
    发明人:PARKER DANE KENTON
    权利人:GOODYEAR TIRE & RUBBER
    摘要:This invention discloses a process for the synthesis of stable aryl nitrile oxides which comprises the sequential steps of (1) halomethylating a halomethyl group onto a substituted aromatic compounds wherein said halomethyl group is halomethylated onto a position that is ortho to at least one of the substituent groups on the substituted aromatic compound; (2) converting the ortho halomethylated-substituted aromatic compound into an ortho-substituted aromatic aldehyde by reacting the ortho halomethylated-substituted aromatic compound with a salt selected from the group consisting of sodium 2-nitropropane and potassium 2-nitropropane in a lower alcohol solvent; (3) converting the ortho-substituted aromatic aldehyde into an ortho-substituted aromatic; and (4) converting the ortho-substituted aromatic oxime into the ortho-substituted aryl nitrile oxide by reacting the ortho-substituted aromatic oxime with an aqueous sodium hypochlorite solution.

    专利号:US-6197920-B1
    优先权日:1999-07-21
    标 题:Formulation for the production of 1, 3-bis (4-aminophenoxy) naphthalene and its polymer
    发明人:CHENG KUN LIN; CHEN WEN-TUNG
    权利人:CHINA TEXTILE INST
    摘要:The present invention relates to the synthesis of new type of diamine monomer, 1,3-bis(4-amonophenoxy)naphthalene, and with such a compound to produce a series of aromatic polymers, including polyamide, polyimide, copoly(amide-imide)s, etc., such polymers having excellent resistance to heat and mechanical properties.

    专利号:US-3992435-A
    优先权日:1975-04-07
    标 题:Process for electrolytic synthesis of polyalkylbiphenylpolycarboxylic acid compounds
    发明人:DONOHUE JOHN A; FIELDS ELLIS K; HART HAROLD
    权利人:STANDARD OIL CO INDIANA
    摘要:Process for coupling alkyl esters of polyalkylbenzoic acid to prepare polyalkylbiphenylpolycarboxylic acid compounds which comprises anodically oxidizing said alkyl esters in a non-nucleophilic media by applying a source of direct current in liquid phase at atmospheric pressure and temperatures from -30 DEG to 80 DEG C. The biphenyl acid compounds are useful in the formation of polyester resins, including alkyds, and fiber-forming polymers.

    专利号:US-8853228-B2
    优先权日:2007-06-04
    标 题:Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase
    发明人:ANDERSON AMY C; WRIGHT DENNIS L; FREY KATHLEEN MARY; PAULSEN JANET LEIGH; SCOCCHERA ERIC WILLIAM; VISWANATHAN KISHORE
    权利人:ANDERSON AMY C; WRIGHT DENNIS L; FREY KATHLEEN MARY; PAULSEN JANET LEIGH; SCOCCHERA ERIC WILLIAM; VISWANATHAN KISHORE; UNIV CONNECTICUT
    摘要:The compositions and methods described herein disclose the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such as Bacillus anthracis and methicillin-resistant Staphylococcus aureus , fungi such as Candida glabrata, Candida albicans and Cryptococcus neoformans and protozoa such as Cryptosporidium hominis and Toxoplasma gondii . These compounds and other similar compounds are also potent against the mammalian enzyme and may be useful as anti-cancer therapeutics.

    专利号:US-7977269-B2
    优先权日:2005-07-21
    标 题:Diimine metal complexes, methods of synthesis, and methods of using in oligomerization and polymerization
    发明人:SMALL BROOKE L; CARNEY MICHAEL
    权利人:CHEVRON PHILLIPS CHEMICAL CO
    摘要:Novel α-diimine metal complexes, particularly iron complexes, having a phenyl sulfidyl or substituted phenyl sulfidyl metal complexing group are disclosed. The α-diimine metal complexes having a phenyl sulfidyl or substituted phenyl sulfidyl metal complexing group are produced by forming one of the α-diimine metal complex imine bonds in the presence of a metal salt or an α-acylimine metal complex. The α-diimine metal complexes having phenyl sulfidyl or substituted phenyl sulfidyl metal complexing group are useful for polymerizing or oligomerizing olefins.
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    合成参考文献


    摘要:Zhdankin, V. V., Science of Synthesis Knowledge Updates, (2015) 1, 237.
    摘要:Singh, F. V.; Wirth, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 54.
    摘要:Jha, N.; Kapur, M., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 115.
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