CAS: 1206102-11-5; (4R,12As)-7-(Benzyloxy)-N-(2,4-Difluorobenzyl)-4-Methyl-6,8-Dioxo-3,4,6,8,12,12A-Hexahydro-2H-Pyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazine-9-Carboxamide

• 英文名称(4R,12As)-7-(Benzyloxy)-N-(2,4-Difluorobenzyl)-4-Methyl-6,8-Dioxo-3,4,6,8,12,12A-Hexahydro-2H-Pyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazine-9-Carboxamide
• 中文名称(4R,12AS)-N-(2,4-二氟苄基)-7-苯氧基-4-甲基-6,8-二氧-3,4,6,8,12,12A-六氢-9-羧基-2H-吡啶并[1',2':4,5]吡嗪并[2,1-B][1,3]噁嗪烷-9-甲酰胺
• IUPAC名称(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
• 其它别名(4R,12As)-N-(2,4-Difluorobenzyl)-7-Benzylhydroxy-4-Methyl-6,8-Dioxo-3,4,6,8,12,12A-Hexahydro-2H-Pyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazine-9-Carboxamide; (4R,12As)-7-(Benzyloxy)-N-(2,4-Difluorobenzyl)-4-Methyl-6,8-Dioxo-3,4,6,8,12,12A-Hexahydro-2H-[1,3]Oxazino[3,2-D]Pyrido[1,2-A]Pyrazine-9-Carboxamide; (4R,12As)-N-[(2,4-Difluorophenyl)Methyl]-3,4,6,8,12,12A-Hexahydro-4-Methyl-6,8-Dioxo-7-(Phenylmethoxy)-2H-Pyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazine-9-Carboxamide; Dolutegravir Intermediate4; (4R,12As)-7-(Benzyloxy)-N-(2,4-Difluorobenzyl)-4-Methyl-6,8-Dioxo-3,4,6,8,12,12A-Hexahydro-2H-Pyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazine-9-Carboxamide; (4R,12As)-N-[(2,4-Difluorophenyl)Methyl]-3,4,6,8,12,12A-Hexahydro-4-Methyl-6,8-Dioxo-7-(Phenylmethox; 3 4 6-Trichlorobenzyl Alcohol 97
• CAS编号1206102-11-5
• MFCD编号:MFCD22741602
• FDA UNII编号:SJ4GZ8739L
• 分子式:C27H25F2N3O5
• 分子量:509.51
• 产品CID: 274962
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• InChIKey: RWEIORQEUUWOLH-ZHRRBRCNSA-N
• InChI=1S/C27H25F2N3O5/c1-16-9-10-36-22-14-31-13-20(26(34)30-12-18-7-8-19(28)11-21(18)29)24(33)25(23(31)27(35)32(16)22)37-15-17-5-3-2-4-6-17/…
• 计算化学: 氢键受体数6.0氢键供体数1可旋转键数6

相似化合物

物理性质

• 沸点761.7±60.0°C at 760 mmHg
• 密度1.42±0.1 g/cm3(预测)
• pKa:10.67±0.40(预测)
• PSA:89.87
• LogP:3.2262
• 储存条件密封, 常温干燥保存

MSDS等安全信息

• GHS符号GHS07
• 警示词Warning
• 危险描述H302-H315-H319-H335
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

上下游产品

合成工艺路线路线简述

• 合成目标产物 (4R,12As)-N-(2,4-Difluorobenzyl)-7-Benzylhydroxy-4-Methyl-6,8-Dioxo-3,4,6,8,12,12A-Hexahydro-2H-Pyrido[1',2':4,5]Pyrazino[2,1-B][1,3]Oxazine-9-Carboxamide 主要起始原料 Methyl 3-(Benzyloxy)-5-((2,4-Difluorobenzyl)Carbamoyl)-1-(2,2-Dimethoxyethyl)-4-Oxo-1,4-Dihydropyridine-2-Carboxylate And 2,4-Difluorobenzylamine
• (文献来源)合成步骤主要原料 Methyl 3-(Benzyloxy)-5-((2,4-Difluorobenzyl)Carbamoyl)-1-(2,2-Dimethoxyethyl)-4-Oxo-1,4-Dihydropyridine-2-Carboxylate 和 2,4-Difluorobenzylamine

海关参考信息

• 2902300000-甲苯
  2905121000-正丙醇
  2905130000-正丁醇
  2906210000-苄醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管