CAS: 121-86-8; 2-Chloro-4-Nitrotoluene

相似化合物

95-74-9 7149-69-1 1260829-25-1

上下游产品

CAS号99-99-0 对硝基甲苯 | CAS号99-54-7 1,2-二氯-4-硝基苯 | CAS号95-49-8 邻氯甲苯 | CAS号99-55-8 2-氨基-4-硝基甲苯 | CAS号121-03-9 对硝基甲苯邻磺酸 | CAS号95-53-4 邻甲苯胺 | CAS号7697-37-2 硝酸 | CAS号7647-18-9 氯化锑(V) | CAS号7782-50-5 氯气 | CAS号105222-71-7 2,2'-DICHLORO-4... | CAS号54439-75-7 2-氯-4-羟基苯甲醛 | CAS号23749-65-7 1,3,5-trichloro... | CAS号99-60-5 2-氯-4-硝基苯甲酸 | CAS号95-74-9 3-氯对甲苯胺 | CAS号42460-61-7 4-氨基-2-氯苯甲醛 | CAS号7149-69-1 1,3-二氯-2-甲基-5-硝基苯 | CAS号7149-79-3 3-氟-4-甲基乙酰苯胺 | CAS号619-19-2 4-硝基水杨酸 | CAS号63155-04-4 4-氯-5-甲基苯-1,2-二胺

4-硝基甲苯置于三氟甲磺酸,三氯异氰尿酸体系中,化学反应 24.0H,以92%的收率获得2-氯-4-硝基甲苯
参考文献:具有吸电子取代基的芳烃催化亲电卤化
标题:具有吸电子取代基的芳烃催化亲电卤化
摘要:芳烃的亲电卤化可能是制备芳基卤化物的最简单方法,芳基卤化物是农用化学品,材料和药物中的重要结构基序.然而,芳烃的亲核性被吸电子取代基削弱,其亲电子卤化反应通常需要苛刻的条件,导致底物范围和应用受到限制.因此,在温和条件下卤化含有吸电子基团(ewgs)和复杂生物活性化合物的芳烃一直是一个长期的挑战.在此,我们描述了在温和条件下具有吸电子取代基的芳烃的 Brønsted 酸催化卤化,为芳基卤化物提供了一种有效的方案.布朗斯台德酸与质子溶剂 1,1,1,3,3 的氢键,
Doi:10.1021/jacs.2C06440

专利信息

专利号:US-9840468-B1
优先权日:2016-12-30
标 题:Methods for the preparation of 6-aminoisoquinoline
发明人：CHAMBOURNIER GILLES; DELONG MITCHELL A
权利人:AERIE PHARMACEUTICALS INC
摘要:Described are methods for the preparation of 6-aminoisoquinoline, a useful intermediate compound in the synthesis of kinase inhibitors.

专利号:US-5969155-A
优先权日:1997-04-11
标题:Conversion of trinitrotoluene into high value compounds
发明人：ETURI SREENIVASA R; BASHIR-HASHEMI ABDOLLAH; IYER SURY
权利人:US ARMY
摘要:The present invention is directed to the synthesis of useful products from the explosive trinitrotoluene. This substance has a limited shelf life as a reliable explosive and large quantities of it have and will become surplus. Ecologically safe, and preferably commercially useful ways of disposing of it are therefore much to be desired. In the present invention the end products are nitroindoles of the general formula 4-Z 1 ,6-Z 2 indole wherein Z 1 and Z 2 are the same or different and are halo or nitro provided at least one of said groups is nitro.

专利号:US-7718598-B1
优先权日:1998-09-25
标 题:Auxiliary for amide bond formation
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programmes. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganizing peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-5786448-A
优先权日:1996-11-07
标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.

专利号:US-6809202-B2
优先权日:1996-11-07
标 题 :Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl gorup and 6-8 atoms in the ring is disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:CN-104902994-B
优先权日:2012-11-06
标 题 :Direct Synthesis of Hydrogen Peroxide