CAS: 123348-27-6; 2-Bromo-7-Iodo-9H-Fluorene

相似化合物

16218-28-3 2523-42-4 1133-80-8

上下游产品

2-溴芴 2-Bromo-9H-Fluorene 1133-80-8
2-碘芴 2-Iodo-9H-Fluorene 2523-42-4
2-氨基-7-溴芴 2-Amino-7-Bromofluorene 6638-60-4
2-氨基-7-碘芴 7-Iodo-9H-Fluorene-2-Amine 34172-48-0
2-溴-9-芴酮 2-Bromofluoren-9-One 3096-56-8
芴 9H-Fluorene 86-73-7

Methyl 4-Bromobiphenyl-2-Carboxylate置于potassium Iodate,氯化亚砜,硫酸,Palladium On Activated Charcoal,氢气,碘,溶剂黄146,Sodium Hydroxide体系中,用 甲醇,二氯甲烷,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 37.0H,反应生成2-溴-7-碘芴
参考文献:一种抗丙肝药物雷迪帕韦关键中间体的制备方法
标题:一种抗丙肝药物雷迪帕韦关键中间体的制备方法
摘要:本发明提供了一种雷迪帕韦关键中间体1‑(7‑溴‑9,9‑二氟‑9H‑芴‑2‑基)‑2‑氯乙酮的制备方法,所述方法以2‑氨基‑5‑溴苯甲酸为原料,经重氮化,碘代,合成5‑溴‑2‑碘苯甲酸,甲酯化,与苯硼酸偶联反应,酯水解,酰氯化,分子内付‑克酰基化,羰基还原,碘代,氟代,最后与2‑氯‑n‑甲氧基‑n‑甲基乙酰胺反应制得目标产物.本工艺起始原料易得,价格低廉,无危险工艺,反应条件温和.

专利信息

专利号:US-9718807-B2
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound
发明人：SCOTT ROBERT WILLIAM; VITALE JUSTIN PHILIP; MATTHEWS KENNETH STANLEY; TERESK MARTIN GERALD; FORMELLA ALEXANDRA; EVANS JARED WAYNE
权利人:GILEAD PHARMASSET LLC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.

专利号:US-9547008-B2
优先权日:2010-01-19
标题:Reagents for directed biomarker signal amplification
发明人：GAYLORD BRENT S; BARTHOLOMEW GLENN P; BALDOCCHI RUSSELL A; HONG JANICE W; HUISMAN WILLIAM H; LIANG YONGCHAO; NGUYEN TRUNG; TRAN LAN T; WHEELER JEAN M; PALMER ADRIAN CHARLES VERNON; UCKERT FRANK PETER
权利人:SIRIGEN INC
摘要:Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

专利号:US-2013324740-A1
优先权日:2012-06-05
标题:Synthesis of antiviral compound

专利号:US-2015232453-A1
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound

专利号:US-2016340345-A1
优先权日:2012-06-05
标题 :Synthesis of antiviral compound

专利号:EP-2855454-B1
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound