Acetone Sodium Bisulfite置于水,羟胺体系中,化学反应生成丙酮肟 参考文献:Theoretical And Experimental Investigation Of The Dynamic Behaviour Of Centrifugal Fans 标题:Theoretical And Experimental Investigation Of The Dynamic Behaviour Of Centrifugal Fans 摘要:本文提出了一个理论模型,用于研究离心风机在压力或流量突然变化时的瞬态行为.该模型基于转子上存在的电机和阻力矩(由于叶片上的压力和粘度作用)的全局建模,以及它们与转子惯性的耦合.在测试的风机中,只要流量不逆转,模型就能正确预测瞬时特性(尤其是流速和转速)的时间和振幅. Doi:10.1155/s1023621X0000021X
专利信息
专利号:US-2023235372-A1 优先权日:2020-06-12 标题:Ab-initio, template-independent synthesis of nucleic acids using thermostable enzymes 发明人:RANDRIANJATOVO-GBALOU IRINA; SAID AHMED; RAHIER RENAUD 权利人:SYNHELIX 摘要:The invention relates to the field of nucleic acid synthesis or sequencing, more specifically to methods for ab-initio synthesis of nucleic acids, comprising contacting a nucleotide with a free 3′-hydroxyl group, with at least one nucleoside triphosphate, or a combination of nucleoside triphosphates, in the presence of an archaeal DNA primase or a functionally active fragment and/or variant thereof, thereby covalently binding said nucleoside triphosphate to the free 3′-hydroxyl group of the nucleotide. It also relates to isolated functionally active fragments of archaeal DNA primases which are capable of both ab-initio single-stranded nucleic acid synthesis activity and template-independent terminal nucleotidyl transferase activity.
专利号:WO-0027627-A1 优先权日:1998-11-12 标题 :Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles 发明人:WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO 权利人:LILLY CO ELI; WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO 摘要:In its first aspect, the invention is directed to a solid support mediated method for the synthesis of diverse polycyclic heterocycles according to general formula (V). A second aspect of the invention is directed to a solid support bound intermediate compound that optionally can be derivatized before a cyclization and displacement procedure provides a product. The intermediate is preferably stable to a wide range of chemical conditions thus allowing, if desired, for the chemical derivatization of the intermediate. A third aspect of the invention is directed to a library of polycyclic heterocycle compounds where said library contains a plurality of diverse library compounds of general formula (V). A fourth aspect of the invention is directed to a method for the synthesis of a library of diverse polycyclic heterocycles by the general method described. A fifth aspect of the invention is directed to an assay kit for the identification of lead compounds of the library described therein.
专利号:WO-2022208508-A1 优先权日:2021-03-31 标 题:Scalable two step synthesis of molnupiravir 发明人:DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; TRIVIKRAM SREENATH; KADAM SACHIN VASANT; DEGAONKAR GAJANAN SUBHASH; MURALIDHARAN KRISHNA; RUPRAJ NARAIN 权利人:FERMENTA BIOTECH LTD 摘要:The present invention provides a scalable two-step synthesis of molnupiravir. The reaction sequence involves the use of commercially easily available cytidine (1), and molnupiravir is formed through direct hydroxy amination of the cytidine followed by esterification of the primary alcohol without protecting dihydroxy groups (vicinal diols) i.e. without formation of acetonide.
专利号:US-10793495-B2 优先权日:2015-08-14 标 题:Synthesis of polyaryl substituted aryl compounds 发明人:BOULOS RAMIZ; FEUTRILL JOHN 权利人:BOULOS & COOPER PHARMACEUTICALS PTY LTD 摘要:A method for the synthesis of a aryl compound of Formula (1).n nU T-W—R 1 ) n    (1)
专利号:WO-2022168106-A1 优先权日:2021-02-06 标题:Chemo-enzymatic process for synthesis of molnupiravir 发明人:DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; TRIVIKRAM SREENATH 权利人:FERMENTA BIOTECH LTD 摘要:Disclosed herein is a process for synthesis of Molnupiravir from cytidine of using a lipase for esterification reaction. The process comprises of reacting compound of formula II with acetone in presence of sulphuric acid to obtain compound of formula III; enzymatically converting compound of Formula III to compound of Formula IV, and Hydroxyaminating Formula IV using Hydroxyl amine sulphate or hydrochloride followed by deprotection to obtain compound of formula I
专利号:WO-2025128106-A1 优先权日:2023-12-14 标 题 :Pharmaceutical intermediates and methods for preparing the same in the synthesis of muscimol and congeners and derivatives thereof 发明人:BOULANGER WILLIAM; TONG ZONGBO 权利人:BOULANGER WILLIAM ALLEN; TONG ZONGBO 摘要:Pharmaceutical intermediates and methods for efficiently preparing muscimol mono-BOC and derivatives thereof in the synthesis of muscimol and congeners and derivatives thereof.