专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-12007376-B2 优先权日:2014-02-26 标题 :Method for determining a concentration of a synthesis component in a radiopharmaceutical sample 发明人:LEBEDEV ARTEM Y; ELIZAROV ARKADIJ M 权利人:TRACE ABILITY INC 摘要:A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.
专利号:US-9744391-B2 优先权日:2009-11-26 标 题:Use of metal-accumulating plants for implementing chemical reactions 发明人:GRISON CLAUDE; ESCARRE JOSE 权利人:CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 2 SCIENCES ET TECHNIQUES 摘要:A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.
专利号:CN-101255090-A 优先权日:2001-12-14 标题 :Synthesis of alpha, beta, beta-trifluorostyrene via in-situ for mation or trifluorovinyl metal halide
专利号:CN-109384829-A 优先权日:2017-08-08 标题 :Methods for the preparation of Nannocystin A and the synthesis of Nannocystin A derivatives
专利号:CN-103275052-A 优先权日:2013-05-24 标题 :Synthesis of Isoflavones by Nickel-Catalyzed Negishi Cross-Coupling Reaction at Room Temperature
参考文献:10.1007/s12011-023-03670-8 摘要:Restrepo Guerrero AG, Martinez VR, Velez Rueda JO, Portiansky EL, De Giusti V, Ferrer EG, Williams PAM. Complexation of the Antihypertensive Drug Olmesartan with Zn: In Vivo Antihypertensive and Cardiac Effects. Biol Trace Elem Res. 2024 Jan;202(1):246–57. doi: 10.1007/s12011-023-03670-8.