CAS: 1377049-84-7; Velpatasvir

上下游产品

2S,4S)-2-[5-[1,11-二氢-2-[(2S,5S)-1-[(2S)-2-[(甲氧羰基)氨基]-3-甲基-1-氧代丁基]-5-甲基-2-吡咯烷基][2]苯并吡喃并[4',3':6,7]萘并[1,2-D]咪唑-9-基]-1H-咪唑-2-基]-4-(甲氧基甲基)-1-吡咯烷羧酸叔丁酯 Tert-Butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[n-(Methoxycarbonyl)-L-Valyl]-5-Methylpyrrolidin-2-Yl}-1,11-Dihydroisochromeno[4',3':6,7]Naphtho[1,2-D]Imidazol-9-yl)-1H-Imidazol-2-Yl]-4-(Methoxymethyl)Pyrrolidine-1-Carboxylate 1378391-45-7
维帕他韦中间体a12 Methyl {(1R)-2-[(2S,4S)-2-(5-{2-[(2S,5S)-1-{(2S)-2-[(Methoxycarbonyl)Amino]-3-Methylbutanoyl}-5-Methylpyrrolidin-2-Yl]-1,4,5,11-Tetrahydroisochromeno[4',3':6,7]Naphtho[1,2-D]Imidazol-9-Yl}-1H-Imidazol-2-yl)-4-(Methoxymethyl)Pyrrolidin-1-Yl]-2-Oxo-1-Phenylethyl}Carbamate 1377604-63-1
叔丁基(2S,4S)-2-[5-(2-{(2S,5S)-1-[n-(甲氧基羰基)-L-缬氨酰]-5-甲基吡咯烷-2-基}-1,4,5,11-四氢异吡喃[4′,3′:6,7]萘并[1,2-D]咪唑-9-基)-1H-咪唑-2-基]-4-(甲氧基甲基)吡咯烷-1-羧酸 Tert-Butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[n-(Methoxycarbonyl)-L-Valyl]-5-Methylpyrrolidin-2-Yl}-1,4,5,11-Tetrahydroisochromeno[4',3':6,7]Naphtho[1,2-D]Imidazol-9-yl)-1H-Imidazol-2-Yl]-4-(Methoxymethyl)Pyrrolidine-1-Carboxylate 1378391-44-6
Tert-Butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[n-(Methoxycarbonyl)-L-Valyl]-5-Methylpyrrolidin-2-Yl}-1,11-Dihydroisochromeno[4',3':6,7]Naphtho[1,2-D]Imidazol-9-yl)-1H-Imidazol-2-Yl]-4-(Methoxymethyl)Pyrrolidine-1-Carboxylate
Methyl {(2S)-1-[(2S,5S)-2-(9-Chloro-1,11-Dihydroisochromene[4',3':6,7]-Naphtho[1,2-D]Imidazol-2-yl)-5-Methylpyrrolidin-1-Yl]-3-Methyl-1-Oxobutan-2-Yl}Carbamate 1378392-96-1
((S)-甲基-1-((2S,5S)-甲基-5-(9-(4,4,5,5-四甲基-1,3,2-二氧杂硼杂环戊烷-2-基))-1,11二氢异色烯[4',3':6,7]萘并[1,2-D]咪唑-2-基)吡咯烷-1-基)-1-氧代丁-2-基)氨基甲酸甲酯 Methyl [(2S)-3-Methyl-1-{(2S,5S)-2-Methyl-5-[9-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1,11-Dihydroisochromeno[4',3':6,7]Naphtho[1,2-D]Imidazol-2-Yl]Pyrrolidin-1-Yl}-1-Oxobutan-2-Yl]Carbamate 1378392-97-2
(2S,5S)-Tert-Butyl 2-(9-Chloro-4,5-Dihydro-5H-Naphtho[c,G]Chromeno[8,9-D]Imidazol-2-yl)-5-(Methyl)Pyrrolidine-1-Carboxylate 1378392-93-8
(2R,4R)-1-Tert-Butyl 2-(2-(9-((2S,5S)-1-((S)-2-(Methoxycarbonylamino)-3-Methylbutanoyl)-5-Methylpyrrolidine-2-Carbonyloxy)-8-Oxo-8,9,10,11-Tetrahydro-5H-Dibenzo[c,G]Chromen-3-yl)-2-Oxoethyl) 4-(Methoxymethyl)Pyrrolidine-1,2-Dicarboxylate 1378391-43-5 (2S,5S)-Tert-Butyl 2-(9-Chloro-5H-Naphtho[c,G]Chromeno[8,9-D]Imidazol-2-yl)-5-Methylpyrrolidine-1-Carboxylate 1378392-94-9 (2S,4S)-2-(2-(9-Bromo-8-Oxo-8,9,10,11-Tetrahydro-5H-Dibenzo[c,G]Chromen-3-yl)-2-Oxoethyl) 1-Tert-Butyl 4-(Methoxymethyl)Pyrrolidine-1,2-Dicarboxylate 1378391-42-4

(2R,4R)-1-Tert-Butyl 2-(2-(9-((2S,5S)-1-((S)-2-(Methoxycarbonylamino)-3-Methylbutanoyl)-5-Methylpyrrolidine-2-Carbonyloxy)-8-Oxo-8,9,10,11-Tetrahydro-5H-Dibenzo[c,G]Chromen-3-yl)-2-Oxoethyl) 4-(Methoxymethyl)Pyrrolidine-1,2-Dicarboxylate置于盐酸,Manganese(Iv) Oxide,(1-Cyano-2-Ethoxy-2-Oxoethylidenaminooxy)Dimethylaminomorpholinocarbenium Hexafluorophosphate,Ammonium Acetate,N,N-二异丙基乙胺体系中,用 1,4-二氧六环,二氯甲烷,乙二醇甲醚,N,N-二甲基甲酰胺,甲苯 用作溶剂,化学反应 20.5H,反应生成维帕他韦
参考文献: Condensed Imidazolylimidazoles As Antiviral Compounds[fr] Imidazolylimidazoles Condensés Utilisés Comme Composés Antiviraux
标题: Condensed Imidazolylimidazoles As Antiviral Compounds[fr] Imidazolylimidazoles Condensés Utilisés Comme Composés Antiviraux
摘要:该披露涉及抗病毒化合物,含有这些化合物的组合物以及包括给予这些化合物的治疗方法,还涉及用于制备这些化合物的过程和中间体.

专利信息

专利号:US-2023364078-A1
优先权日:2022-05-12
标题:Method of preparing nanoparticles comprising poorly water soluble drugs for treating hepatitis
发明人：KIM HYUN CHUL; MOON BYOUNG YONG
权利人:EVEX TECH INC
摘要:The present invention provides nanoparticles which contain a poorly water-soluble drug for treating hepatitis, and a method of producing the nanoparticles. More particularly, the present invention provides a method of producing nanoparticles for treating hepatitis, which includes: a first step of preparing a precursor mixture solution for synthesis of nanoparticles which include a drug for treating hepatitis; a second step of extracting the compound under supercritical or subcritical conditions; and a third step of dispersing the same, as well as the nanoparticles including a poorly water-soluble drug for treating hepatitis with improved bioavailability and without organic solvent residue.

专利号:US-10344009-B2
优先权日:2015-11-03
标题 :Process for the preparation of sofosbuvir
发明人：JAYACHANDRA SURESHBABU; KAUSHIK VIPIN KUMAR; RAVI VIJAYA KRISHNA; DEV VIKAS CHANDRA; KOTTOLLA SAIPRASAD; RAO POTLA VENKATA SRINIVASA; VAKITI SRINIVAS; MUGGU CHAITANYA; DANDALA SUBRAMANYAM
权利人:MYLAN LABORATORIES LTD
摘要:A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein.

专利号:US-12404246-B1
优先权日:2024-10-01
标 题:2-aminomethylimidazole mimics of NS4A and their effect thereof on hepatitis C virus NS3 protease
发明人：BARADWAN MOHAMMED A; OMAR ABDELSATTAR M; ELFAKY MAHMOUD A; EL-ARABY MOUSTAFA E; SOROR SAMEH H
权利人:BARADWAN MOHAMMED A; OMAR ABDELSATTAR M; ELFAKY MAHMOUD A; EL ARABY MOUSTAFA E; SOROR SAMEH H; UNIV KING ABDULAZIZ
摘要:Chronic hepatitis C is a global health problem affecting large number of people and leads to mortalities and morbidities. In this invention, new compounds belonging to 2-substituted-1H-imidazole-4-carboxamide derivatives (Formula I) intended for use in the treatment of hepatitis C are disclosed. The compounds interfere with the important viral peptide NS4A co-enzyme function. The described art includes chemical synthesis, spectral confirmation and binding assays with NS3 protein.

专利号:CN-105732563-A
优先权日:2016-03-23
标题:A new method for the synthesis of 9-bromo-3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9h)-one

专利号:CN-105732563-B
优先权日:2016-03-23
标 题 :A kind of new method of the bromo- 3- of synthesis 9- (2- acetyl bromides) -10,11- dihydro -5H- dibenzo [c, g] chromene -8 (9h) -one

专利号:CN-111087421-A
优先权日:2019-12-24
标题:A kind of preparation method of phosphoramide compound for chiral drug synthesis