CAS: 174-78-7; 2-Oxa-6-Azaspiro[3.3]Heptane

相似化合物

1045709-32-7 1159599-99-1 1263285-88-6

上下游产品

CAS号13573-28-9 6-(对甲苯磺酰)-2-氧杂-... | CAS号1159599-99-1 2-氧杂-6-氮杂-螺[3,3...

三溴新戊醇置于potassium Carbonate,Magnesium体系中,用 甲醇,乙醇 用作溶剂,化学反应 94.0H,反应生成2-氧杂-6-氮杂-螺[3,3]庚烷
参考文献:新型3,5,7-三取代吡唑并[1,5-A]嘧啶的合成及生物活性评价
标题:新型3,5,7-三取代吡唑并[1,5-A]嘧啶的合成及生物活性评价
摘要:Flt3 蛋白激酶的突变通常与急性髓性白血病中细胞增殖失调有关,抑制该激酶是一种潜在的治疗策略.我们报告了一系列新的 3,5,7-三取代吡唑并 [1,5-A ] 嘧啶,旨在研究它们的生物活性,特别是对 Flt3-Itd 及其下游调节剂以及对 Cdk2 和 Cdk9 的生物活性.衍生物10B能够强烈抑制所有激酶,其在 Flt3-Itd 表达细胞系 Molm13 和 Mv4-11 中的选择性与 Flt3-Itd 抑制作用一致.进一步的生化分析和分子对接证实 Flt3 是10B的细胞靶标.
Doi:10.1016/j.Bmcl.2022.129096

专利信息

专利号:US-11897914-B2
优先权日:2021-11-29
标题 :Synthesis of 2′ protected nucleosides
发明人：POON WING C; ZOU RUIMING; LAU ALDRICH N K; YU DAVID; Du Gengyu; YAO YUN-CHIAO; ZHAO GANG
权利人:HONGENE BIOTECH CORP
摘要:Embodiments of the present application relate to the preparation of 2′-O-protected nucleoside phosphoramidites and conjugation of the 2′-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2′ position that reduces migration to the 3′ position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.

专利号:US-2023119227-A1
优先权日:2020-02-24
标 题:Oligonucleotide synthesis on solid support
发明人：JI AN; MARVIN MICHAEL; MARKS KEVIN; ANDERSON DAVID
权利人:INTEGRATED DNA TECH INC
摘要:Functionalized solid supports are useful in the synthesis of oligonucleotides. The functionalized solid supports contain an extended linker to a terminal functional group or a first nucleotide or nucleoside moiety. The extended linker permits oligonucleotide synthesis to take place at a greater distance from the solid support with greater efficiency.

专利号:US-12180182-B2
优先权日:2021-12-01
标题 :(Di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same
发明人：DAI MINGJI
权利人:PURDUE RESEARCH FOUNDATION
摘要:One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.

专利号:US-11691135-B2
优先权日:2020-10-15
标 题:Synthesis of alkynones via carbonylative Sonogashira coupling reactions catalyzed by Pd(II)-N-Heterocyclic carbene-pyridine complexes
发明人：EL ALI BASSAM; MANSOUR WASEEM; FETTOUHI MOHAMMED
权利人:UNIV KING FAHD PET & MINERALS; SAUDI ARABIAN OIL CO
摘要:This disclosure relates to N-substituted Pd(II)-N-heterocyclic carbene-pyridine complexes, methods of preparing the complexes, and methods of using the complexes in Sonogashira coupling reactions.

专利号:US-11142545-B2
优先权日:2016-06-24
标 题 :Synthesis of thiolated oligonucleotides without a capping step
发明人：SHI XIANGLIN; YANG JIMIN; KIESMAN WILLIAM F; FILLON YANNICK
权利人:BIOGEN MA INC
摘要:The invention herein describes a solid-phase synthetic method for preparing thiolated oligonucleotides without needing a capping step. The methods of the invention comprises repetition of a three-reaction per cycle, namely detritylation, coupling and sulfurization, without a capping step. In some embodiments, the synthetic methods of the present invention can be used for preparing an anti-sense oligonucleotide.

专利号:US-11192912-B1
优先权日:2020-10-15
标 题 :Synthesis of biaryl ketones and biaryl diketones via carbonylative Suzuki-Miyaura coupling reactions catalyzed by bridged bis(N-heterocyclic carbene)palladium(II) catalysts
发明人：EL ALI BASSAM; MANSOUR WASEEM; FETTOUHI MOHAMMED
权利人:UNIV KING FAHD PET & MINERALS; SAUDI ARABIAN OIL CO
摘要:This disclosure relates to bridged bis(N-heterocyclic carbene)palladium(II) complexes, methods of preparing the complexes, and methods of using the complexes in Suzuki-Miyaura coupling reactions.