CAS: 28380-24-7; Nigericin

上下游产品

CAS号138285-65-1 1,30-Dddn

Nigericin Sodium Salt置于高氯酸体系中,用 氯仿 用作溶剂,化学反应 1.0H,反应生成尼日利亚菌素
参考文献: Ligand Ionophore Conjugates[fr] Conjugués Ligand-Ionophore
标题: Ligand Ionophore Conjugates[fr] Conjugués Ligand-Ionophore
摘要:本发明涉及配体-离子载体共轭物,可能还包括连接的治疗剂或成像剂,并含有该共轭物的药物组合物.还描述了使用这些共轭物来增加治疗剂或成像剂在内体器的积累和逃逸的方法.

专利信息

专利号:US-5905091-A
优先权日:1996-07-03
标 题 :Enhancement of skin pigmentation by prostaglandins
发明人：FULLER BRYAN B
权利人:UNIV OKLAHOMA
摘要:A composition comprising a carrier and prostaglandin effective in stimulating synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin and optionally comprising a lysosomotropic agent, a phosphodiesterase inhibitor, and/or methylxanthines, and a method of use of the composition. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation.

专利号:WO-2018005963-A1
优先权日:2016-07-01
标 题:Synthesis of new methylumbelliferone prodrugs and their incorporation into lipid-based drug delivery formulations
发明人：SZOKA FRANCIS C JR; DAI ZHIPENG
权利人:ZONEONE PHARMA INC
摘要:Lipophilic prodrugs of 4-methylumbelliferone are incorporated into lipid based drug delivery systems (e.g., emulsions, micelles, liposomes and lipid particles). The formulations protect 4-methylumbelliferone from first pass hepatic metabolism to 4-MUG. Exemplary formulations are oral and parenteral formulations. Methods of treating proliferative diseases, e.g., cancer by administering the formulation to a subject in need thereof are provided.

专利号:US-12018305-B2
优先权日:2018-12-10
标题:Process for production of nigericin from Streptomyces sp. MCC-0151
发明人：SYED GULAM DASTAGER; SAHU AMIT KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:A fermentation process is provided for the synthesis of Nigericin from Streptomyces sp. having accession number MCC 0151 and its isolation with high yield. A microbial inoculant composition is provided, comprising a biologically pure culture of Streptomyces sp. MCC 0151 for the exclusive production of Nigericin with high yield.

专利号:US-12428442-B2
优先权日:2017-06-21
标题 :Compounds, compositions and methods for synthesis
发明人：BUTLER DAVID CHARLES DONNELL; HENCKEN CHRISTOPHER P; IWAMOTO NAOKI; KANDASAMY PACHAMUTHU; LANAO ALVARO ANDRES; LU GENLIANG; SHIMIZU MAMORU; DIVAKARAMENON SETHUMADHAVAN; VARGEESE CHANDRA; BOMMINENI GOPAL REDDY; MARAPPAN SUBRAMANIAN
权利人:WAVE LIFE SCIENCES LTD
摘要:The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

专利号:US-8648035-B2
优先权日:2007-08-17
标题 :Identification and use of peptide inhibitors of protein synthesis
发明人：LLANO-SOTELO BEATRIZ; MANKIN ALEXANDER S; KLEPACKI DOROTA
权利人:LLANO-SOTELO BEATRIZ; MANKIN ALEXANDER S; KLEPACKI DOROTA; UNIV ILLINOIS
摘要:The present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an interaction at a stem-loop H18 in 16S rRNA of a 30S ribosomal subunit. Screening methods for peptides are disclosed, in addition to methods of determining the affinity of a test compound for a ribosomal subunit.

专利号:US-9217150-B2
优先权日:2008-03-20
标题 :NRPS-PKS gene cluster and its manipulation and utility
发明人：JØRGENSEN HANNE; ELLINGSEN TROND ERLING; DEGNES KRISTIN FLØGSTAD; BRUHEIM PER; SLETTA HÃ…VARD; FJAERVIK ESPEN; KLINKENBERG GEIR; ZOTCHEV SERGEY
权利人:JØRGENSEN HANNE; ELLINGSEN TROND ERLING; DEGNES KRISTIN FLØGSTAD; BRUHEIM PER; SLETTA HÃ…VARD; FJAERVIK ESPEN; KLINKENBERG GEIR; ZOTCHEV SERGEY; SINTEF TTO AS
摘要:The present invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 1; or (b) a nucleotide sequence which is the complement of SEQ ID No. 1; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 1; or (d) a nucleotide sequence having at least 85% sequence identity (preferably at least 87%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity) with SEQ ID No. 1; or (e) a part of any one of (a) to (d), wherein said nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. Particularly the invention contemplates the modification of the nucleic acid of the invention, encoding the biosynthetic machinery for the synthesis of the polyketide macrolactam BE-14106, including expressing in a microorganism the modified nucleic acid molecule. In certain aspects the modification includes introducing, mutating, deleting, replacing or inactivating a sequence encoding one or more activities or proteins encoded by said nucleic acid molecule. Other aspects of the invention include a microorganism containing the modified and unmodified nucleic acid and recovering the polyketide-based or macrolactam molecule from said microorganism.