CAS: 4780-79-4; Naphthalen-1-Ylmethanol

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CAS号66-77-3 1-萘甲醛 | CAS号86-55-5 1-萘甲酸 | CAS号201230-82-2 carbon monoxide | CAS号90-14-2 α-碘萘 | CAS号86-52-2 1-氯甲基萘 | CAS号97-94-9 三乙基硼 | CAS号118-31-0 1-萘甲胺 | CAS号250293-43-7 1-Naphthaldehyd... | CAS号113688-53-2 1-tributylstann... | CAS号557-20-0 二乙基锌 | CAS号105578-63-0 2-(naphthalen-1... | CAS号321-38-0 1-氟萘 | CAS号143659-34-1 naphthalen-1-yl... | CAS号1466-24-6 1-(dimethoxypho... | CAS号18818-37-6 2-naphthalen-1-... | CAS号66-77-3 1-萘甲醛 | CAS号86-55-5 1-萘甲酸 | CAS号90-12-0 1-甲基萘 | CAS号35310-62-4 1-(naphthalen-1...

3-[(1-羟基-2-萘基)偶氮]苯磺化钠置于氢气,C28H25Brmnn2O2P,Lithium Tert-Butoxide体系中,用 丙醇 作为反应溶剂,100.0 °C,5.07 Mpa 条件下,反应 12.0H,以80%的收率获得产物1-萘甲醇
参考文献:锰催化剂加氢酯类
标题:锰催化剂加氢酯类
摘要:开发了膦-氨基吡啶配体锰络合物催化酯的氢化反应.使用该协议,各种(杂)芳香族和脂肪族羧酸盐(包括生物质衍生的酯和内酯)被氢化成伯醇,产率为 63-98%.发现锰催化剂对苯甲酸甲酯的氢化具有活性,可提供高达 45,000 的周转数 (Ton) 的苯甲醇.对催化剂中间体的研究表明,酰胺锰络合物是该反应的活性催化剂.
DOI:10.1002/adsc.202101376

专利信息

专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人：SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.

专利号:WO-03031376-A1
优先权日:2001-10-12
标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one
发明人：MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.

专利号:US-6022963-A
优先权日:1995-12-15
标 题:Synthesis of oligonucleotide arrays using photocleavable protecting groups
发明人：MCGALL GLENN H; NAM NGO QUOC
权利人:AFFYMETRIX INC
摘要:Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting group has the general formula Ar-C(R1)(R2)-O-C(O)- wherein: Ar is an optionally substituted fused polycyclic aryl or heteroaromatic group or a vinylogous derivative thereof; R1 and R2 are independently H, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or optionally substituted heteroaromatic, or a vinylogous derivative of the foregoing; and X is a leaving group, a chemical fragment linked to Ar-C(R1)(R2)-O-C(O)- via a heteroatom, or a solid support; provided that when Ar is 1-pyrenyl and R1=R2=H, X is not linked to Ar-C(R1)(R2)-O-C(O)- via a nitrogen atom. Preferred embodiments are those in which Ar is a fused polycyclic aromatic hydrocarbon and in which the substituents on Ar, R1 and R2 are electron donating groups. A particularly preferred protecting group is the 'PYMOC' protecting group, pyrenylmethyloxycarbonyl, where Ar=pyrenyl and R1=R2=H. Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-6127515-A
优先权日:1997-11-18
标 题:Functionalized resin for the synthesis of amides and peptides
发明人：MANFRE FRANCO; VANASSE BENOIT J; LABAUDINIERE RICHARD F; MORTON GEORGE C
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR 1 ; and R 1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.

专利号:US-6133409-A
优先权日:1996-12-19
标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.