CAS: 533-50-6; (S)-1,3,4-Trihydroxybutan-2-One

上下游产品

CAS号141-46-8 羟乙醛 | CAS号3369-79-7 Β-羟基丙酮酸锂 水合物 | CAS号2319-57-5 L-苏丁醇 | CAS号210230-62-9 L-erythrofuranose | CAS号1113-60-6 羟基丙酮酸 | CAS号50-00-0 甲醛 | CAS号96-26-4 1,3-二羟基丙酮 | CAS号24940-63-4 calcium bis(hyd... | CAS号64-17-5 乙醇 | CAS号6968-16-7 DL-苏糖醇 | CAS号95-43-2 D-苏糖 | CAS号56-81-5 甘油 | CAS号124-38-9 二氧化碳 | CAS号107-02-8 丙烯醛 | CAS号57-55-6 丙二醇 | CAS号2418-52-2 D-苏糖醇 | CAS号107-21-1 乙二醇

羟乙醛置于magnesium(II) Chloride Hexahydrate,焦磷酸硫胺素,Recombinant Geobacillus Stearothermophilus Transketolase H102L/l118I/h474S Mutant体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应生成 L(+)-赤藓酮糖(水合)
参考文献:转酮酶变体催化醛的交叉偶姻缩合用于合成脂肪族 α-羟基酮
标题:转酮酶变体催化醛的交叉偶姻缩合用于合成脂肪族 α-羟基酮
摘要:我们证明来自嗜热脂肪地芽孢杆菌的转酮醇酶变体催化涉及两个羟基化或非脂肪族醛的偶姻缩合反应.这种混杂的 Tk 催化反应为通常 Tk 机制中用作供体底物的 α-酮酸的酮醇转移提供了一种有吸引力的替代方案,通过避免二氧化碳释放来增加原子经济性.转酮醇酶变体 H102L/l118I/h474G(S) 对丙醛和较小程度的乙醛的自缩合表现出从头活性,并且具有控制与丙醛更具挑战性的交叉偶姻缩合反应的选择性的显着能力或异丁醛用作亲核试剂,不同的羟基化醛(c2-C4)用作亲电试剂.由化学计量的醛合成七种脂肪族对称和不对称 α-羟基酮,其产率与基于 α-酮酸脱羧的常见 Tk 反应获得的产率相似.这种新颖的酶促交叉偶姻缩合反应扩展了合成不对称脂肪族 α-羟基酮的工具箱,同时改进了先前酶促和化学策略的质量指标.
DOI:10.1039/d4Gc01373E

专利信息

专利号:US-5200516-A
优先权日:1990-02-16
标 题:Synthesis of sugars from substituted and unsubstituted arene diols
发明人：HUDLICKY TOMAS
权利人:VIRGINIA TECH INTELL PROP
摘要:There are disclosed processes for the synthesis of substituted and unsubstituted arene diols useful in the further synthesis of sugars, sugar derivatives, chiral synthons or amino acids.

专利号:US-5939304-A
优先权日:1997-06-05
标题:Method for synthesis of anhydrothrombin
发明人：SUZUKI TOYOAKI; HOSOKAWA KAZUYA; NAGATA MASANORI
权利人:FUJIMORI KOGYO CO
摘要:A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields. n The method comprises n (A) a step of causing an active serine residue site of thrombin to react with an inhibitor, n (B) a step of performing an alkali treatment at a pH of not less than 11, and n (C) a step of performing an operation of recovery, and carries out these steps sequentially in the order mentioned, and is characterized by causing at least the step of performing the operation of recovery to proceed in the presence of at least one compound selected from the group consisting of polyhydric alcohols and saccharides, and a salt or an amphoteric electrolyte.

专利号:US-8105809-B2
优先权日:2008-07-03
标题 :Enzymatic synthesis of acetoacetate esters and derivatives
发明人：HENDERSON SAMUEL T
权利人:HENDERSON SAMUEL T; ACCERA INC
摘要:In one embodiment, the present invention includes a method for the synthesis of an ester derivative of acetoacetate. The method includes providing a first ester of acetoacetate and providing an alcohol. The method further includes combining the first ester of acetoacetate and the alcohol in the presence of an enzyme capable of transesterification in a non-aqueous solvent to form the ester derivative of acetoacetate. The method results in the formation of the ester derivative of acetoacetate, which, in one embodiment, is monoacetoacetin.

专利号:US-8183355-B2
优先权日:2006-04-28
标题 :Method for the synthesis of oligonucleotide derivatives
发明人：MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE
权利人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE; CENTRE NAT RECH SCIENT
摘要:Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistryâ€? reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. n Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.

专利号:US-2025236633-A1
优先权日:2022-03-28
标 题:Synthesis of isomerically pure polyol-based phosphoramidites
发明人：BANASIK BRENT; DIAZ CORRAL JULIAN ANDRES; JACOBS AARON; JUD LUKAS; KUCHELMEISTER HANNES; NBAVI MELUD; PFAFFENEDER TONI; SIMONYIOVA SONA; TABONE JOHN C; THUER WILMA
权利人:ROCHE SEQUENCING SOLUTIONS INC
摘要:The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers.

专利号:WO-2006095359-A1
优先权日:2005-03-10
标题:Synthesis of 2-deoxy-2, 2-di fluoro-d-ribo furanose-3, 5 di(4-methy/4-nitro-chloro)benzoate and its conversion to gemcitabine hydrochloride thereof
发明人：POTLURI RAMESH BABU; VENKATA SUBRAMANIAN HARIHARAKR; BETINI RAMESH; GUNTURU SATYANARAYANA
权利人:SMS PHARMACEUTICALS LTD; POTLURI RAMESH BABU; VENKATA SUBRAMANIAN HARIHARAKR; BETINI RAMESH; GUNTURU SATYANARAYANA
摘要:The invention describes the synthesis of hereto unreported 2-deoxy-2,2-difluoro-D-ribofuranose-3,5-di-(aroyl) derivative of formula-Vb, where in R=;CH3,CI,NO2 and its conversion to Gemcitabine HCl of formula-I, an anti cancer product.