CAS: 7751-38-4; Diisopropyldichlorosilane

该化合物是一种该化合物是一种有机合成和硅酮化学的多功能中间体,特别是用于将二异丙基硅酸组引入分子结构.它的主要优点包括高纯度,一致的再活性和与一系列子质的相容性,因此对于表面修改,聚合物合成和医药中保护性组化学等应用非常有用.该化合物的二氯硅烷功能允许在受控制的条件下高效地交叉连接或功能化.建议由于惰性大气中的湿度敏感度和对蛋白溶剂的再活性,在惰性大气中进行适当处理.

结构式图片

相似化合物

18395-90-9 2227-29-4 13154-24-0

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ECHA物质C&L通报

上下游产品

CAS号1068-55-9 异丙基氯化镁 | CAS号920-39-8 异丙基溴化镁 | CAS号10026-04-7 四氯化硅 | CAS号75-29-6 2-氯丙烷 | CAS号2227-29-4 二异丙基氯代硅烷 | CAS号18173-88-1 dihydroxy-di(pr... | CAS号85272-30-6 二异丙基硅基双(三氟甲烷磺酸盐) | CAS号347904-48-7 chloro-(4-metho... | CAS号162578-85-0 °Ctadecyl Diiso... | CAS号19753-69-6 1 1 2 2-TETRAIS... | CAS号87351-60-8 1,1,2,2,3,3-hex... | CAS号166592-75-2 chloro-pent-4-e... | CAS号65549-78-2 chloro-phenyl-d... | CAS号79848-13-8 1,1,2,2,3,3,4,4... | CAS号89332-24-1 [phosphanyl-di(...

合成工艺路线路线简述

    异丙基氯化镁置于四氯化硅体系中,用 四氢呋喃,甲苯 作为反应溶剂,化学反应 5.0H,反应生成 二异丙基二氯硅烷
    参考文献:Production Processes For Triorganomonoalkoxysilanes And Triorganomonochlorosilanes
    标题:Production Processes For Triorganomonoalkoxysilanes And Triorganomonochlorosilanes
    摘要:含有庞大烃基或基团r的硅烷,其具有式(Iii)R3-(X+y)(R1)X(R2)Ysi(Or3),可通过反应式(I)(R1)X(R2)Ysicl3-(X+y)(Or3)的硅烷与式(II)Rmgx的格氏试剂制得.此外,式(Xiia)(R1)(R2)(R3)Sicl的三有机氯硅烷可通过反应式(Xia)(R1)(R2)(R3)Siz1的三有机硅烷与盐酸制得.再者,当式(Xxi)(R1)X(R2)Ysicl4-(X+y)的硅烷与式(Xxii)Rmgx的格氏试剂反应,并在反应过程中加入并反应酒精或环氧化合物时,可制得式(Xxiii)R3-(X+y)(R1)X(R2)Ysi(Or3)的三有机单烷氧基硅烷.

    专利信息


    专利号:US-6242614-B1
    优先权日:1999-05-28
    标 题:Semi-synthesis of paclitaxel using dialkyldichlorosilanes
    发明人:VEMISHETTI PURUSHOTHAM; GIBSON FRANCIS S; DILLON JOHN L
    权利人:BRISTOL MYERS SQUIBB CO
    摘要:A process for the synthesis of paclitaxel from 10-deacetylbaccatin-III which is protected at the 7-position with a dialkylalkoxysilyl protecting group having the formula —Si(R) 2 (OR′).

    专利号:US-6180718-B1
    优先权日:1996-03-01
    标题:Process for preparation of aromatic and heteroaromatic molecules
    发明人:BOEHM TERRI L; HODGES JOHN C; SHOWALTER HOWARD D H
    权利人:WARNER LAMBERT CO
    摘要:A process for the attachment of aromatic or heteroaromatic rings to a polymeric support via a silyl ether linkage is described. Such process involves the synthesis of a chlorodialkyl aryl or heteroarylsilane which is then coupled to a polymeric support via a hydroxyl functionality to form a polymer-bound silyl ether. Further modification provides a polymer-bound small organic molecule that is cleaved from the polymeric support under mild conditions to give an aryl or heteroaryl silanol or a compound in which the aryl or heteroaryl carbon-silicon bond is replaced with a carbon-hydrogen, carbon-halogen, carbon-hydroxyl, carbon-sulfur, or carbon—carbon bond. Such methods are useful for the preparation of a library of diverse aromatic and heteroaromatic compounds by both manual and automated synthesis.

    专利号:US-11691883-B2
    优先权日:2018-09-10
    标题:Synthesis of trichlorosilane from tetrachlorosilane and hydridosilanes
    发明人:AUNER NORBERT; STURM ALEXANDER G
    权利人:MOMENTIVE PERFORMANCE MAT INC
    摘要:The invention relates to a process for the preparation of trichlorosilane (HSiCl3) which comprises the reaction of tetrachlorosilane (SiCU) with hydridosilanes in the presence of a catalyst.

    专利号:EP-1391459-A1
    优先权日:1999-08-11
    标 题:Process for the preparation of a paclitaxel C-4 methyl carbonate analog and intermediates
    发明人:KANT JOYDEEP
    权利人:BRISTOL MYERS SQUIBB CO
    摘要:A process for the synthesis of a C-4 methyl carbonate paclitaxel analog from 10-deacetylbaccatinnIII by the selective reduction of the acetate at the C-4 position ofn10-deacetylbaccatin using Red-Al.

    专利号:US-12384803-B2
    优先权日:2020-02-24
    标 题:Non-cryogenic synthesis of heteroatom-bridge precursors of metal-ligand complex catalysts
    发明人:DO HIEN Q; FONTAINE PHILIP P; KRASOVSKIY ARKADY L; SPENCER LIAM P; OGAWA KELLI A; LESNIEWSKI DANIEL K; ANDERSON RUSSELL W
    权利人:DOW GLOBAL TECHNOLOGIES LLC
    摘要:Embodiments are directed to a metal-ligand complex catalyst precursor, (L1)(L2)X(R1)(R2), and methods for producing the same from a compound of formula Q2X(R1)(R2). L1 and L2 are independently —R3—Z1 or —R4—Z1. R1 and R2 are independently selected from a hydrogen atom, (C1-C40)hydrocarbyl and, optionally, R1 and R2 are connected to form a ring having from 3 to 50 atoms in the ring, excluding hydrogen atoms. X is Si, Ge, Sn, or Pb. Each Q is independently Ar1—Y1R3— or Ar2—Y2—R4—. R3 and R4 are independently selected from —(CRC2)m—, where m is 1 or 2, and where each RC is independently selected from the group consisting of (C1-C40)hydrocarbyl, (C1-C40)heterohydrocarbyl, and —H. Y1 and Y2 are independently S, Se, or Te. Ar1 and Ar2 are independently (C6-C50)aryl. Ar1—Y1—R3— and Ar2—Y2—R4— are not identical. Each Z1 is independently selected from Cl, Br, and I.

    专利号:US-6353120-B2
    优先权日:1999-08-11
    标 题:Process for the preparation of a paclitaxel C-4 methyl carbonate analog
    发明人:KANT JOYDEEP
    权利人:BRISTOL MYERS SQUIBB CO
    摘要:A process for the synthesis of a C-4 methyl carbonate paclitaxel analog from 10-deacetylbaccatin III by the selective reduction of the acetate at the C-4 position of 10-deacetylbaccatin using Red-Al.
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    主要参考文献

    参考标题:Palladium‐catalyzed Synthesis Of Benzophenanthrosilines By C−h/c−h Coupling Through 1,4‐palladium Migration/alkene Stereoisomerization
    作者:Tomohiro Tsuda,Yuka Kawakami,Seung‐min Choi,Ryo Shintani |发布日期:2020.5.18
    摘要:Catalysis. The Reaction Mechanism Has Been Experimentally Investigated And A Catalytic Cycle Involving A C-H/c-H Coupling Through A New Mode Of 1,4-Palladium Migration With Concomitant Alkene Stereoisomerization Has Been Proposed.

    合成参考文献


    摘要:Skrydstrup, T., Science of Synthesis, (2002) 4, 271.
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