CAS: 99665-00-6; (6R,7R)-7-[[2-(Difluoromethylsulfanyl)Acetyl]Amino]-3-[[1-(2-Hydroxyethyl)Tetrazol-5-Yl]Sulfanylmethyl]-7-Methoxy-8-Oxo-5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid

上下游产品

7-(N-4-methylbenzamide)-3-(chloromethyl)-8-oxo-5-oxo-1-azabicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid diphenylmethyl ester (6R,7R)-7-(amino)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]°Ct-2-ene-2-formic acid diphenylmethyl ester (6R,7R)-7-(2-((difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]°Ct-2-ene-2-formic acid diphenylmethyl ester (6R,7R)-benzhydryl 7-(4-methylbenzamide)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylate

拉氧头孢杂质置于penicillin Acylase Pga-300,碳酸氢钠,三乙胺,三氟乙酸体系中,用 二氯甲烷,N,N-二甲基甲酰胺,甘油 作为反应溶剂,化学反应 11.0H,反应生成 氟氧头孢
参考文献:一种氟氧头孢钠的制备方法
标题:一种氟氧头孢钠的制备方法
摘要:本发明属于氟氧头孢钠新制备方法,具体涉及一种氟氧头孢钠的制备方法:由化合物(I)在硝酸铈铵的催化下与甲醇反应反应生成化合物(II),接着与四氮唑侧链进行连接得到化合物(Iii),在酶解作用下脱去氨基保护基和羟基保护基得到化合物(Iv),通过和二氟甲基巯基乙酸活性酯的中间体反应得到化合物(V),然后在三氟乙酸作用下脱去羧基保护基得到化合物(Vi),最后通过成钠盐反应得到氟氧头孢钠(Vii).反应路线如下:本发明的方法设计合理,具有以下优点:反应操作简便,可靠,反应路线短,绿色环保,产率高,后处理容易,得到高纯度的氟氧头孢钠.

专利信息

专利号:WO-0032619-A1
优先权日:1998-11-30
标题:Methods and compositions for identification of inhibitors of ribosome assembly
发明人：DAMMEL CAROL S; WATSON JULIE C
权利人:RIBOGENE INC
摘要:The invention provides a means for identifying novel antibiotics by screening for compounds that inhibit bacterial ribosome assembly and ribosomal protein synthesis, which comprises the screening of test compounds to identify those that inhibit the activity of a bacterial ribosomal protein. The in vitro and in vivo assays detect (a) increased translation of a reporter mRNA that is normally repressed in the presence of a ribosomal protein, (b) increased growth in cells that over-express ribosomal protein, and (c) decreased binding of the ribosomal protein to its target RNA. The invention encompasses the (a) methods of screening and testing compounds by the above methods, (b) compounds that are identified in the assay which inhibit ribosome assembly and protein synthesis and (c) methods for treatment using said compounds.

专利号:US-2025002508-A1
优先权日:2020-05-05
标题 :Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof
发明人：HECKER SCOTT J; BOYER SERGE HENRI; BIO MATTHEW M; FANG YUANQING; GONZALES DE CASTRO ANGELA; LEFORT LAURENT; ZHU ZUOLIN; LINDER THOMAS
权利人:QPEX BIOPHARMA INC
摘要:Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

专利号:US-6528631-B1
优先权日:1993-09-03
标题 :Oligonucleotide-folate conjugates
发明人：COOK PHILLIP DAN; MANOHARAN MUTHIAH; BHAT BALKRISHEN
权利人:ISIS PHARMACEUTICALS INC
摘要:Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage sites. The folate can be attached via the α- or γ-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed.

专利号:US-11135200-B2
优先权日:2014-12-20
标题:Antimicrobial drug synthesis and therapeutic compositions
发明人：GREGG JOHN MALCOLM HALL
权利人:GREGG JOHN MALCOLM HALL
摘要:This invention relates to the medical use of an antimicrobial agent, racemic Ornidazole, its (R) and (S) enantiomers, or pharmaceutically acceptable salts or esters thereof, and to methods of treatment which involve treating a subject with Ornidazole. The racemic (rac)-ornidazole, its enantiomers, or pharmaceutically acceptable salts or esters thereof, may be used in combination with other actives. The invention also relates to pharmaceutical formulations and compositions comprising (rac)-ornidazole, (R)-ornidazole, (S)-ornidazole, or pharmaceutically acceptable salts or esters thereof, and/or other actives as well as methods to stereoselectively manufacture the enantiomers.

专利号:US-9149445-B2
优先权日:2009-07-27
标 题:Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections
发明人：LIU SEAN; RABINOWITZ JOSHUA D; SHENK THOMAS
权利人:LIU SEAN; RABINOWITZ JOSHUA D; SHENK THOMAS; UNIV PRINCETON
摘要:A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme.

专利号:WO-2014017797-A1
优先权日:2012-07-25
标题:Novel method for preparing 1-oxacephalosporin derivative
发明人：LEE SANG GYUN; HA HONG JOO; CHU SO MI; AN JUNG GI
权利人:JE IL PHARMACEUTICAL CO LTD
摘要:The present invention relates to a novel method for preparing a 1-oxacephalosporin derivative, which is an intermediate for the synthesis of 1-oxacephalosporin which is useful as an antibacterial agent. The preparation method of the present invention uses a simple halogenating agent to show remarkable stability, have a simple reaction process, allow a reaction to be readily controlled, and reduce reaction time, and thus is very efficient and improves the production yield of 1-oxacephalosporin which is useful as an antibacterial agent.