CAS: 21948-70-9; 2-Methylthiopyrazine

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CAS号14508-49-7 2-氯吡嗪 | CAS号5188-07-8 甲硫醇钠 | CAS号74-88-4 碘甲烷 | CAS号28217-95-0 2-苄基吡嗪 | CAS号89815-18-9 2-[(4-methoxyph...

二甲基二硫,2-碘吡嗪置于三乙烯二胺,Fac-Tris(2-Phenylpyridinato-N,C2')Iridium(III),二甲基亚砜体系中,用 乙腈 用作溶剂,化学反应 24.0H,以85%的收率获得2-甲硫基吡嗪
参考文献:芳基,杂芳基和乙烯基碘的可见光光催化硫醇化†
标题:芳基,杂芳基和乙烯基碘的可见光光催化硫醇化†
摘要:由容易获得的卤化物进行的芳基和乙烯基硫醚的一般催化合成仍然是一个挑战.本文中,我们报告了使用可见光光氧化还原催化用二烷基二硫化物对芳基和乙烯基碘进行硫醇化的统一方法.可以以高收率和优异的化学选择性获得一系列带有不同官能团的硫醚产品.我们通过一系列富含硫醚的天然产物的便捷合成证明了该方法的多功能性.从稳态和时间分辨的发光猝灭以及瞬态吸收光谱实验,对光催化机理进行了详细的研究.
Doi:10.1039/c8Ob00238J

专利信息

专利号:WO-2011047481-A1
优先权日:2009-10-23
标题 :Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
权利人:MERCK FROSST CANADA LTD; FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl- coenzyme. A delta-9 desaturase (SCDl) relative to other known stearoyl-coenzyme. A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. Formula (I).