专利号:US-4822903-A 优先权日:1981-05-15 标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof 发明人:JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT 权利人:RHONE POULENC SPEC CHIM 摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.
专利号:WO-2021078995-A1 优先权日:2019-10-25 标 题 :Selective polypeptide synthesis stalling assay and compound 发明人:STROUS GERARDUS JACOBUS ANTONIUS MARIA; MOL JAN ADRIANUS; VAN DER VELDEN LIEKE MARIE; KLUMPERMAN JUDITH; MAAS PETRUS EMMANUEL MARIE; PIET DENNIS PATRICK; DE KLERK-SPRENKELS NANDA ELISABETH; TIJHUIS JOHANN HEINRICH; VIÉTOR HENDRIK ENGELBERTUS; MAURICE MADELON MARIA; VAN DER KRIFT FELIX 权利人:UMC UTRECHT HOLDING BV; UNIV UTRECHT HOLDING BV; BIMINI BIOTECH B V 摘要:The invention relates to compounds, in particular pyrimidine-2,4-diamines, analogues and salts thereof and pharmaceutical compositions comprising pyrimidine-2,4-diamines analogues and salts thereof for use in the treatment and prevention of a disease, in particular a growth hormone receptor-dependent condition. The invention also relates to methods of using these compounds and compositions to treat physiological disorders related to the amount or activity of growth hormone. In a particular embodiment, the invention relates to a compound according to formula 1 for use in the treatment or prevention of a disease in a subject.
专利号:US-9868718-B2 优先权日:2006-01-06 标 题 :Cycloalkylamines as monoamine reuptake inhibitors 发明人:SHAO LIMING; WANG FENGJIANG; MALCOLM SCOTT CHRISTOPHER; HEWITT MICHAEL CHARLES; BUSH LARRY R; MA JIANGUO; VARNEY MARK A; CAMPBELL UNA; ENGEL SHARON RAE; HARDY LARRY WENDELL; KOCH PATRICK; CAMPBELL JOHN E 权利人:SUNOVION PHARMACEUTICALS INC 摘要:The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
专利号:CN-111205202-A 优先权日:2020-02-29 标题:A kind of symmetrical geminal difluoroolefin derivative containing quaternary carbon center and its synthesis method
专利号:CN-115490664-A 优先权日:2022-09-29 标 题 :Synthesis and application of a class of fluorescent probes for selective detection of homocysteine
专利号:CN-115417846-B 优先权日:2022-09-21 标 题 :A kind of two-state high fluorescent material based on coumarin and its synthesis method and application
摘要:Cheng, B.; Wang, T., Science of Synthesis Knowledge Updates, (2020) 3, 142. 参考文献:10.1021/ja011876o 摘要:Fulton JR, Sklenak S, Bouwkamp MW, Bergman RG. A comprehensive investigation of the chemistry and basicity of a parent amidoruthenium complex. J Am Chem Soc. 2002 May 01;124(17):4722–37. doi: 10.1021/ja011876o.