专利号:WO-2021148064-A1 优先权日:2020-01-22 标 题 :Biodegradable polyurethane foam, biodegradable polyurethane foam-based material for saccharide-cleaving enzyme production, method of synthesis and use thereof 发明人:BENES HYNEK; BUJOK SONIA; PARUZEL ALEKSANDRA; ZAJICOVA VERONIKA; HNATKOVA TEREZA; BUSSCHER GUUSKE FREDERIKE; SCHMEETS ALEX ALOIS JOSEPH 权利人:USTAV MAKROMOLEKULARNI CHEMIE AV CR V V I; BIOMOSAE 摘要:The present invention relates to a method of synthesis of a biodegradable polyurethane foam, comprising the following steps: i) mixing of at least one aliphatic isocyanate bearing at least two isocyanate groups with at least one saccharide in weight ratio of from 1:1 to 30:1 to form a saccharide-isocyanate precursor; ii) homogenization of the saccharide-isocyanate precursor from step i) with 20 to 70 % (w/w) of at least one biodegradable aliphatic polyester-ether polyol having molecular mass in the range of from 0 to 10 000 g/mol and hydroxyl number from 10 to 100 mgKOH/g, 1 to 5 % (w/w) of water, and 1 to 10 % (w/w) of at least one blowing agent other than water, related to the total weight of the resulting mixture; iii) foaming of the homogenized mixture from step ii) at the temperature of from 20 to 100 °C, resulting in the biodegradable polyurethane foam comprising incorporated saccharide. The invention further relates to a biodegradable polyurethane foam obtainable by this method, to a biodegradable polyurethane foam-based material for saccharide-cleaving enzyme production and to the use thereof.
专利号:US-2023111600-A1 优先权日:2019-12-17 标题 :Polymeric fatty acid compounds for the treatment of fibrous amino acid-based substrates, especially hair 发明人:WAGNER ROLAND; STREICHER KATHARINA; ROHMANN LAURA; WENSKE CHRISTIAN; HAVELI SHRUTISAGAR DATTATRAYA 权利人:MOMENTIVE PERFORMANCE MAT GMBH 摘要:The present invention is directed at mono-, di- or polyquaternary ammonium compounds of the formula (I) wherein x is 1 to 50, and F can be the same or different and is represented by the general formula (II) wherein at least one of the optionally substituted and optionally functional-group-containing hydrocarbon radicals R 1 , R 2 , R 3 , R 4 or R 5 contains at least one estolide moiety comprising two or more ester or amide moieties. The invention also relates to a process for the synthesis of such compounds, the use of the compounds in cosmetic formulations for skin and hair care, cosmetic compositions for the treatment of fibers, and compositions containing one or more of the compounds for the treatment of hair.
专利号:US-2024308959-A1 优先权日:2021-06-29 标 题:Processes for the preparation of (s)-2-(4-chloro-2-methoxyphenyl)-2-((3 -methoxy-5-(m ethylsulfonyl)phenyl)amino)-1 -(1h-indol-3-yl)ethenone derivatives 发明人:WU KAI; OOST RIK; SCHWEITZER-CHAPUT BERTRAND; ERIKSSON CARL ARNE MAGNUS; COESEMANS ERWIN 权利人:JANSSEN PHARMACEUTICALS INC 摘要:The present invention relates to novel chiral synthesis of mono- or di-substituted indole compounds of formula (I) n n n n n n n n n n n n wherein: n R 1 is H, R 2 is F and R 3 is H or CH 3 , n R 1 is H, CH 3 or F, R 2 is OCH 3 and R 3 is H and n R 1 is H, R 2 is OCH 3 and R 3 is CH 3 , n R 1 is CH 3 , R 2 is F and R 3 is H, n R 1 is CF 3 or OCF 3 , R 2 is H and R 3 is H, n R 1 is OCF 3 , R 2 is OCH 3 and R 3 is H and n R 1 is OCF 3 , R 2 is H and R 3 is CH 3 .
专利号:US-2007173517-A1 优先权日:2006-01-20 标 题:Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides 发明人:WIRTH THOMAS; KROEBER JUTTA; NICOLA THOMAS; RAPP ARMIN; GUTHEIL DIETER; ORLICH SIMONE A; WANG XIAO-JUN; KRISHNAMURTHY DHILEEPKUMAR 权利人:WIRTH THOMAS; KROEBER JUTTA; NICOLA THOMAS; RAPP ARMIN; GUTHEIL DIETER; ORLICH SIMONE A; WANG XIAO-JUN; KRISHNAMURTHY DHILEEPKUMAR 摘要:Disclosed is an improved multi-step process for preparing a compound of Formula I: n n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
专利号:US-6600001-B1 优先权日:2002-01-11 标 题:Alkylamino oxamides as low odor, non-fugitive catalysts for the production of polyurethanes 发明人:GERKIN RICHARD M; ROBINSON KARENA KAYE; DERERIAN EDMOND J 权利人:CROMPTON CORP 摘要:A process for the synthesis of polyurethanes is disclosed wherein the process comprises reacting polyurethane-forming reactants in the presence of an effective amount of a catalyst comprising at least one alkylamino oxainide of the structure:wherein:R1 and R2 are independently selected alkyl groups or can be taken together to form a five or six-membered heterocyclic ring;R3 and R4 are independently selected from the group consisting of hydrogen and alkyl;n is 2 or 3;x is 0 or 1;Y is selected from the group consisting of O and NR9, wherein:R9 is selected from the group consisting of hydrogen and alkyl; andX is selected from the group consisting of OR10 and G, wherein:R10 is selected from the group consisting of hydrogen and alkyl; andG is
专利号:US-7470795-B2 优先权日:2004-07-27 标 题:Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides 发明人:WANG XIAO-JUN; WIRTH THOMAS; NICOLA THOMAS; ZHANG LI; FRUTOS ROGELIO PEREZ; XU YIBO; KRISHNAMURTHY DHILEEPKUMAR; NUMMY LAURENCE JOHN; VARSOLONA RICHARD J; SENANAYAKE CHRIS HUGH; KROEBER JUTTA; REEVES DIANA 权利人:BOEHRINGER INGELHEIM PHARMA; BOEHRINGER INGELHEIM INT 摘要:Disclosed is a multi-step process for preparing a compound of Formula I: n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
[参考文献]: B Ballantyne, Et Al. The Acute Toxicity And Irritancy Of Bis[参考文献]: Chao-Shan Da, Et Al. Highly Catalytic Asymmetric Addition Of Deactivated Alkyl Grignard Reagents To Aldehydes. Org Lett. 2009 Dec 17;11(24):5578-81.
合成参考文献
参考文献:10.1021/ol052150q 摘要:Wang XJ, Zhang L, Sun X, Xu Y, Krishnamurthy D, Senanayake CH. Addition of grignard reagents to aryl acid chlorides: an efficient synthesis of aryl ketones. Org Lett. 2005 Dec 08;7(25):5593–5. doi: 10.1021/ol052150q.