CAS: 329-65-7; Adrenaline

该化合物是肾上腺腺激素和激素,在人体的抗争或飞行反应中发挥着关键作用,使身体在紧张情况下能够快速行动.该化合物的特点是能够刺激甲型和乙型肾上腺受体,导致各种生理影响,如心率上升,血液流向肌肉的增强和血液凝糖水平升高.从化学角度讲,肾上腺素具有C10H13NO3的分子分子配方,并具有主要矿物质组的催化素结构.该物质是一种手动分子,存在于两种对应形式中,但种族混合物()表明它含有抗菌剂.肾上腺素在水中可溶解,熔点相对较低.在医疗环境中,特别是在诸如厌食素等紧急情况下,它作为血管抑制剂和支气管剂,在各种治疗剂中使用.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号36467-25-1 2-(苄基甲基氨基)-3',4... | CAS号62-13-5 盐酸肾上腺酮 | CAS号104819-56-9 R,S-2,2'-dinitr... | CAS号99-45-6 肾上腺酮 | CAS号120-80-9 邻苯二酚 | CAS号20677-73-0 2,2-二乙氧基-N-甲基乙-1-胺 | CAS号51-43-4 肾上腺素 | CAS号67-04-9 酒石酸辛弗林 | CAS号51-43-4 肾上腺素 | CAS号672-73-1 4-[1-Hydroxy-2-... | CAS号50-53-3 氯丙嗪 | CAS号121-33-5 香草醛 | CAS号62-32-8 N-甲基多巴胺 | CAS号26405-77-6 肾上腺素磺酸 | CAS号54-06-8 肾上腺色素 | CAS号642-75-1 adrenolutin | CAS号3736-29-6 2,3-Dihydro-1-m... | CAS号5707-55-1 Dopal

合成工艺路线路线简述

    3-(1-羟基-2-(甲基氨基)乙基)苯酚置于二羟基富马酸,Acetate Buffer,氧气,Horse Radish Peroxidase体系中,化学反应生成消旋肾上腺素
    参考文献:Preparative Hydroxylation Of Aromatic Compounds Catalyzed By Peroxidase
    标题:Preparative Hydroxylation Of Aromatic Compounds Catalyzed By Peroxidase
    摘要:
    Doi:10.1021/ja00410A067

    海关参考信息

    专利信息


    专利号:US-2025214918-A1
    优先权日:2022-05-20
    标 题:Functionalization of terpenes by selective deprotonation for the synthesis of (+)-artemisinin and related compounds
    发明人:FRANTZ DOUG E; BLUMBERG SHAWN; ORTIZ ELIEZER; CLANTON NICHOLAS; WILSON NICK
    权利人:UNIV TEXAS
    摘要:The present invention provides methods for the preparation of (+)-Artemisinin and intermediates thereof, including via the regioselective deprotonation of amorphadiene (AD). In other aspects, there are provided methods for the functionalization terpenes by selective deprotonation, including the utilization of 4,11-amorphadiene as an industrially viable feedstock for the synthesis of artemisinin. In some embodiments, these methods are broadly applicable to the derivatization of a variety of cyclic and linear terpenes.

    专利号:EP-2465936-A1
    优先权日:2010-12-20
    标题 :Enzymatic synthesis of statins and intermediates thereof
    权利人:LEK PHARMACEUTICALS
    摘要:The present invention discloses a process for preparing an active pharmaceutical ingredient (API) or intermediates thereof, notably particular step in the synthesis of an intermdiate useful for example in the preparation of statins, by using an enzyme capable of catalyzing oxidation or dehydrogenation. The invention further provides an expression system effectively translating said enzyme. In addition, the invention relates to a specific use of such enzyme for preparing API or intermediate thereof, and in particular for preparing statin or interemediate thereof.

    专利号:US-5043328-A
    优先权日:1986-05-09
    标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
    发明人:WEITHMANN KLAUS U
    权利人:HOECHST AG
    摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

    专利号:US-11311505-B2
    优先权日:2017-02-24
    标 题:Synergistic compositions to stimulate the synthesis of human lung and sinus surfactants to decrease coughing, increase FEV-1/FVC ratios, decrease lung fibrosis, by increasing apoptosis of myofibroblasts
    发明人:MARTIN ALAIN
    权利人:MARTIN ALAIN; CELLULAR SCIENCES INC
    摘要:Methods for the treatment of patients with both Chronic Obstructive Pulmonary Disease (COPD) and pulmonary fibrosis, and of patients with idiopathic pulmonary fibrosis without COPD, by stimulating the synthesis of human and animal patient lung and sinus surfactants to increase lung functions, inhibiting fibrosis and reducing coughing and nasal erythema, include the following steps: A) analyzing and diagnosing a patient with a lung ailment selected from the group consisting of i) both COPD and pulmonary fibrosis; and ii) idiopathic pulmonary fibrosis without COPD; and, B) treating the patient to raise the patient's lung functions including FEV1/FVC ratio by contacting mammalian cells with a [therapeutically effective amount of a treatment] composition that includes: a) a pyruvate salt; b) a phosphate; c) a salt of calcium; and d) a salt of magnesium, in an aqueous carrier, containing no more than 2.2 grams of said pyruvate salt per liter.

    专利号:US-2024132430-A1
    优先权日:2021-08-05
    标 题 :Chemicals and use of hypohalites in mechanism-based selective dual radical organic synthesis
    发明人:PALOMINO EDUARDO
    权利人:WALKER CANCER RES INSTITUTE INC
    摘要:The synthesis of pattern-specific compounds using hypohalites, such as hypochlorous acid, sodium hypochlorite, and potassium hypoiodite, as dual-radical generators is provided. The synthesis can be implemented by a cyclization reaction, a dehydrogenation reaction, a hydroxylation reaction, a decarboxylation reaction, or any combination of the above four. The reactions are typically carried out in water, in a nonpolar solvent such as ethyl acetate, or a mixture of both. Hypochlorous acid is made by adding a weak acid such as acetic acid to sodium hypochlorite.

    专利号:US-5280093-A
    优先权日:1989-06-29
    标题 :Chiral polymers for the synthesis of pure enantiomers of amino acids
    发明人:JACQUIER ROBERT; CALMES MONIQUE; DAUNIS JACQUES
    权利人:RHONE POULENC CHIMIE
    摘要:The present invention relates to chiral polymers and to their uses for operations of asymmetric synthesis, deracemization and optical inversion. n These polymers are characterized in that they comprise: n a chiral unit n a functionalizing unit n an optional crosslinking unit n Application to chiral organic synthesis.
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    主要参考文献


    1: Petrocheilou A, Tanou K, Kalampouka E, Malakasioti G, Giannios C, Kaditis AG. Viral croup: diagnosis and a treatment algorithm. Pediatr Pulmonol. 2014 May;49(5):421-9. doi: 10.1002/ppul.22993. Epub 2014 Mar 5. (10):CD006619. doi: 10.1002/14651858.CD006619.pub3. 2(5):575-8. doi: 10.1016/j.jaip.2014.02.014. Epub 2014 Apr 18. 53(6):659-62. doi: 10.1093/ajhp/53.6.659. 37(2):165-70. 9(5):326-332. doi: 10.1542/hpeds.2018-0066.
    7: Food and Drug Administration, HHS. Labeling for bronchodilators to treat asthma; cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use. Final rule. Fed Regist. 2011 Jul 26;76(143):44475-89. 15(6):586-594. doi: 10.1007/s12519-019-00291-x. Epub 2019 Jul 25.
    61:189-202. doi: 10.1093/bmb/61.1.189. 339(8):498-503. doi: 10.1056/NEJM199808203390802.

    合成参考文献


    摘要:S10 | SWISSPHARMA | Pharmaceutical List with Consumption Data | DOI:10.5281/zenodo.2623484
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