CAS: 72748-99-3; (R)-2-(Methoxymethyl)Pyrrolidin-1-Amine

该化合物是一种手性丙烯衍生物,具有氨基氨基组和2位置的甲基替代物,该化合物是不对称合成,特别是制药和农用化学制剂的制作过程中的一个宝贵构件.其立体化学纯度使其适合需要对应选择性催化或辅助框架的应用.甲基乙酰胺组增加了有机溶剂的溶性,促进了其在多种反应条件下的使用.作为二级矿,它可以参与再处理,核生殖替代和其他变异.其硬性丙烯基质骨质有助于控制合成途径的立体化学结果.该化合物通常供应高的抗蛋白性过剩,确保研究和工业应用中的再生能.

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CAS号72748-98-2 (R)-2-(methoxym...

合成工艺路线路线简述

  • 合成目标产物 (R)-(+)-1-Amino-2-(Methoxymethyl)Pyrrolidine 主要起始原料 D(-)Prolinol
  • (文献来源)合成步骤主要原料 D(-)Prolinol
D-脯氨醇置于potassium Hypochlorite,Sodium Hydride,Potassium Hydroxide体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 12.83H,反应生成 1-氨基-2-(甲氧基甲基)-吡咯
参考文献:(S)-(−)-1-Amino-2-Methoxymethylpyrrolidine (Samp) And (R)-(+)-1-Amino-2-Methoxymethylpyrrolidine (Ramp),Versatile Chiral Auxiliaries
标题:(S)-(−)-1-Amino-2-Methoxymethylpyrrolidine (Samp) And (R)-(+)-1-Amino-2-Methoxymethylpyrrolidine (Ramp),Versatile Chiral Auxiliaries
摘要:
DOI:10.15227/orgsyn.065.0173

海关参考信息

专利信息


专利号:US-5229474-A
优先权日:1991-03-20
标题 :Synthesis of two-dimensional polymers by molecular recognition and chemical reaction among high molar mass monomers
发明人:STUPP SAMUEL I
权利人:UNIV ILLINOIS
摘要:A new variety of side chain liquid crystal polymers. The macromolecules of these materials are comb-shaped and differ from conventional side-chain liquid crystal polymers in that the comb's teeth are longer and semi flexible. The oligomeric side chains contain a long flexible spacer not only at their junction with the backbone but also in the center of the mesogen. Specific features of the systems include monosubstitution of enantiotopic protons in the central spacer by a cyano group and a long alkoxy tail at the terminus. An unusual property of these materials is a lower liquid crystal-isotropic transition temperature relative to that of their monomeric precursors.

专利号:US-12129274-B2
优先权日:2018-04-03
标题:Modular synthesis of aminoglycosides
发明人:CALABRESE ANDREW ANTONY; KANE TIMOTHY ROBERT; HILDEBRANDT DARIN; LOPEZ MICHAEL; EVDOKIMOV NIKOLAI; COHEN FREDERICK; BAYRAKDARIAN MALKEN; XU SANIJIA; DESJARDINS SAMUEL; SOUEIDAN OLIVIER
权利人:REVAGENIX INC
摘要:The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.

专利号:US-2022411456-A1
优先权日:2018-04-03
标题 :Modular synthesis of aminoglycosides

专利号:US-11673907-B2
优先权日:2018-04-03
标 题:Modular synthesis of aminoglycosides

专利号:US-6407103-B2
优先权日:1998-04-21
标 题:Indeno [1,2-c] pyrazol-4-ones and their uses
发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-8969249-B2
优先权日:2004-05-10
标 题:Synthesis and biological activity of bicyclic ABA analogs
发明人:ABRAMS SUZANNE; CUTLER ADRIAN J; ROSE PATRICIA; NYANGULU JAMES; NELSON KEN M
权利人:ABRAMS SUZANNE; CUTLER ADRIAN J; ROSE PATRICIA; NYANGULU JAMES; NELSON KEN M; NAT RES COUNCIL CANADA
摘要:Bicyclic abscisic acid (ABA) analogs of Formula (I) and (II) and the process for their production are disclosed. The bicyclic ABA analogs include the structural elements and functional groups of the parent molecule that are required for activity, and have an aromatic ring fused to the ring replacing the vinyl methyl group of absicisie acid. Methods for using the bicyclic ABA analogs to inhibit cell growth and seed germination are also disclosed.
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主要参考文献

参考标题:Enantioselective Synthesis Of Protected α-Hydroxy Aldehydes And Ketones Via Hydroxylation Of Metalated Chiral Hydrazones
作者:Dieter Enders,Vidya Bhushan |发布日期:1988.1
摘要:α-Benzyloxy Aldehydes And α-Acetoxy Ketones 4 Of High Enantiomeric Purity Are Prepared In Good Overall Yields Via Oxaziridine Mediated Hydroxylation Of Chiral Hydrazone Azaenolates. As Auxiliaries Novel Proline Derived Hydrazine Reagents 5 Are Used.

合成参考文献


摘要:Göttlich, R., Science of Synthesis, (2007) 25, 363.
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