CAS: 104641-60-3; (R)-3-Hydroxy-1-Methyl-Pyrrolidine

相似化合物

13220-33-2 100858-32-0 100858-33-1

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CAS号50-00-0 甲醛 | CAS号40499-83-0 3-羟基吡咯烷 | CAS号104706-47-0 (R)-3-羟基吡咯烷盐酸盐 | CAS号131237-81-5 3-hydroxy-N-met...

(R)-1-Methyl-3-Pyrrolidinol(2R,3R)-Tartrate置于氢氧化钾体系中,化学反应生成(R)-(-)-1-甲基-3-羟基吡咯烷
参考文献:Fused Aromatic Oxazepinones,Thiazepinones,Diazepinones And Sulfur
标题:Fused Aromatic Oxazepinones,Thiazepinones,Diazepinones And Sulfur
摘要:芳香族氮杂七元酮和硫醚的化学式为##str1##其中;A为苯,萘,喹啉或吡啶;B为氧或硫;E为氧,硫或##str2##n为1,2或3;Z为氨基或含氮杂环的基团;R为氢,较低烷基,环烷基或苯基较低烷基;Y为卤素,较低烷基,较低烷氧基,二较低烷基氨基,硝基,氨基,较低乙酰氨基,三氟甲基,苯基或被从卤素,较低烷基,较低烷氧基,二较低烷基氨基,硝基,氨基,较低酰胺基或三氟甲基中选择的一个至三个y'基团取代的苯基;具有抗组胺作用,公开了其制备方法和化学中间体.

专利信息

专利号:US-10975101-B2
优先权日:2016-05-31
标题:Ultra-potent vinca alkaloids: added molecular complexity further disrupts the tublin dimer-dimer interface
发明人：BOGER DALE
权利人:SCRIPPS RESEARCH INST
摘要:Synthetically-derived and previously inaccessible modifications of 20′-hydroxy-vinca derivative compounds such as vinblastine, vincristine or vindesine are disclosed that are a stunning 100-fold more active than the natural product (IC 50 's 50-75 pM vs 7 nM, HCT116), and are now accessible as a result of advances in the total synthesis of the natural product. Illustrative new ultra-potent vinblastines bind tubulin with much higher affinity and likely further disrupt the tubulin head-to-tail α/β dimer-dimer interaction by virtue of the strategic placement of an added conformationally well-defined, rigid and extended C20′-urea along the adjacent protein-protein interface. Added molecular complexity was used to markedly enhance target binding and functional biological activity, and represents a general approach to improving the properties of other natural products targeting a protein-protein interaction. A pharmaceutical composition containing an ultra-potent 20′-hydroxy-vinca derivative compound and a method of treating cancerous cells with such a compound are also disclosed.

专利号:US-8633227-B2
优先权日:2008-12-01
标 题 :Synthesis and novel salt forms of (R)-3-((E)-pyrrolidin-3-yl)vinyl)-5-tetrahydropyran-4-yloxy)pyridine
发明人：AKIREDDY SRINIVASA RAO; BREINING SCOTT R; CUTHBERTSON TIMOTHY J; DULL GARY MAURICE; GATTO GREGORY J; GENUS JOHN; HAMMOND PHILIP S; MITCHENER JR JOESPH PIKE; MUNOZ JULIO A; OTTEN PIETER ALBERT; YOHANNES DANIEL; FEDOROV NIKOLAI
权利人:AKIREDDY SRINIVASA RAO; BREINING SCOTT R; CUTHBERTSON TIMOTHY J; DULL GARY MAURICE; GATTO GREGORY J; GENUS JOHN; HAMMOND PHILIP S; MITCHENER JR JOESPH PIKE; MUNOZ JULIO A; OTTEN PIETER ALBERT; YOHANNES DANIEL; FEDOROV NIKOLAI; TARGACEPT INC
摘要:The present invention relates to (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions.

专利号:US-2012015983-A1
优先权日:2008-12-01
标 题 :Synthesis and Novel Salt Forms of (R)-3-((E)-pyrrolidin-3-yl)vinyl)-5-tetrahydropyran-4-yloxy)pyridine

专利号:US-2014107163-A1
优先权日:2008-12-01
标题:Synthesis and novel salt forms of (r)-3-((e)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine