专利号:WO-2012095438-A1 优先权日:2011-01-12 标 题 :Particles and suspensions of cephalosporin antibiotics 发明人:NIEDERMANN HANS PETER; BOTHE HEIKO 权利人:INTERVET INT BV; NIEDERMANN HANS PETER; BOTHE HEIKO 摘要:Disclosed is a method of making particles of a cephalosporin antibiotic, particularly cefquinome, wherein use is made of diafiltration. The diafiltration can be with anti- solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.
专利号:US-9066864-B2 优先权日:2011-01-12 标 题:Use of liquid medium exchange by cross flow filtration in the preparation of drug suspensions 发明人:NIEDERMANN HANS PETER; BOTHE HEIKO 权利人:NIEDERMANN HANS PETER; BOTHE HEIKO; INTERVET INC 摘要:Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti-solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.
专利号:CN-221108190-U 优先权日:2023-10-23 标 题 :Ammonia removal device in the synthesis of 7-ACQ intermediates
专利号:CN-103193799-A 优先权日:2013-03-29 标 题:A kind of chemical synthesis method of cefquinome sulfate
专利号:CN-103193799-B 优先权日:2013-03-29 标题 :A kind of chemical synthesis process of Cefquinome sulfate
1: Liu C, Han M, Wang H, Chen X, Tang Y, Zhang D, Li X, Liu Y. Elimination of Cefquinome Sulfate Residue in Cow's Milk after Intrauterine Infusion. Metabolites. 2023 Mar 29;13(4):492. doi: 10.3390/metabo13040492. 2: El-Tahawy AO, Said AA, Shams GA, Hassan HM, Hassan AM, Amer SA, El-Nabtity SM. Evaluation of cefquinome's efficacy in controlling avian colibacillosis and detection of its residues using high performance liquid chromatography (HPLC). Saudi J Biol Sci. 2022 May;29(5):3502-3510. doi: 10.1016/j.sjbs.2022.02.029. Epub 2022 Feb 25. 3: Durna Corum D, Corum O, Terzi E, Coskun D, Bilen S, Cetin G, Uney K. Pharmacokinetics of cefquinome in rainbow trout (Oncorhynchus mykiss) after intravascular, intraperitoneal, and oral administrations. J Vet Pharmacol Ther. 2022 Nov;45(6):578-583. doi: 10.1111/jvp.13091. Epub 2022 Aug 24. 11(3):342. doi: 10.3390/antibiotics11030342.
合成参考文献
参考文献:10.1007/s11270-024-07606-3 摘要:Ullah M, Rana S, Hossain M. A Cost-Effective, Eco-Friendly and Functional Wastewater Pre-Treatment Procedure Development for the Degradation of β-Lactam Antibiotic Residues Discharged from Cephalosporin Drug Manufacturing Plant. Water Air Soil Pollut. 2024 Nov 26;236(1). doi: 10.1007/s11270-024-07606-3.