专利号:US-4937367-A 优先权日:1987-07-15 标 题:Process for the preparation of intermediates for the synthesis of fosfomycin 发明人:CASTALDI GRAZIANO; GIORDANO CLAUDIO 权利人:ZAMBON SPA 摘要:A process is described for the preparation of intermediates useful in the synthesis of Fosfomycin. n More particularly, an enantioselective process is described for the preparation of derivatives of (1S,2S)-1,2-dihydroxypropyl-phosphonic acid of formula ##STR1## wherein R 2 and R 3 have the meanings reported in the specification.
专利号:US-9968710-B2 优先权日:2007-07-23 标 题:Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition 发明人:DUEWELHENKE NICOLE 权利人:BIOMET DEUTSCHLAND GMBH 摘要:Use of a pharmaceutical composition for the local treatment or prevention of a tissue infection at an infection site, the pharmaceutical composition comprising at least two different antibiotics of group A or pharmaceutically acceptable derivatives thereof, or an antibiotic of group A and at least one antibiotic of group B or pharmaceutically acceptable derivatives thereof. Group A comprises primarily intracellular active antibiotics working as inhibitor of bacterial RNA polymerase; as inhibitor of gyrase; or as inhibitor of bacterial protein synthesis. Group B comprises primarily extracellular active antibiotics working as inhibitor of bacterial cell wall synthesis; or inhibitor of bacterial protein synthesis; or by direct destabilization or rupture of the bacterial cell wall.
专利号:CN-105524953-B 优先权日:2015-12-21 标题 :The method of one step catalysis method synthesis of chiral drug phosphonomycin preparation of chloroperoxidase
专利号:EP-0299484-B1 优先权日:1987-07-15 标题 :Process for the preparation of intermediates for the synthesis of fosfomycin
专利号:WO-2024147727-A1 优先权日:2023-01-05 标 题 :Synthesis of fosfomycin disodium 发明人:DE LA ROSA BARRALES ARTURO 权利人:INTERQUIM S A DE C V 摘要:The present invention provides a method for preparing fosfomycin disodium using sodium hydroxide and levo-fosfomycin dextro-phenylethylamine salt as raw materials to prepare a high-purity sodium fosfomycin product.
专利号:EP-0299484-A1 优先权日:1987-07-15 标 题:Process for the preparation of intermediates for the synthesis of fosfomycin
摘要:Moody, T. S.; Mix, S.; Brown, G.; Beecher, D., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 447. 摘要:Iyakuhin Kenkyu. Study of Medical Supplies., 12(668), 1981