CAS: 2794-60-7; Barium Trifluoromethanesulfonate

该化合物是一种有机氨酸化合物,其特点是结核与三氟乙烷磺酸的阴离子形式配有的结,其特点是极地溶剂中的溶性较高,这是强酸盐的典型特征.三氟甲基化合物的存在具有独特的特性,例如各种化学反应,特别是有机合成和催化反应中的稳定性和潜在应用增加.盐形式表明,它可能表现出特定的离子特性,包括潜在的溶解传导性.此外,三氟甲基化合物可增强化合物的亲性并影响其再活动.安全考虑很重要,因为化合物具有毒性,适当的处理至关重要.

结构式图片

相似化合物

60871-83-2 34946-82-2 88189-03-1

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

trifluorormethanesulfonic acid Trifluoromethanesulfonyl fluoride1,3-diphenyl-1H-imidazol-3-ium trifluoromethanesulfonate trifluorormethanesulfonic acid potassium trifluoromethansulfonate sodium triflate

合成工艺路线路线简述

    三氟甲基磺酰氟 在 Barium(II) Hydroxide体系中,获得 Barium Trifluoromethanesulfonate
    参考文献:一种利用超重力反应制备三氟甲磺酸金属盐的方法
    标题:一种利用超重力反应制备三氟甲磺酸金属盐的方法
    摘要:本申请属于精细化工和环保领域,具体涉及一种利用超重力反应制备三氟甲磺酸金属盐的方法.该方法包括如下的步骤:一,以三氟甲基磺酰氯,无水hf气体为原料,反应生成三氟甲磺酰氟气体;二,将三氟甲磺酰氟气体水洗除杂,与碱金属溶液按进行气液接触反应,得到混合溶液;三,对混合溶液通过压滤机进行固液分离,液相为三氟甲磺酸盐溶液;四,三氟甲磺酸盐溶液通过喷雾干燥器干燥后,得到固相产品三氟甲磺酸盐.本申请的方法以三氟甲基磺酰氯,无水hf为原料替代传统方法中的三氟甲磺酸,利用超重力反应,大大降低了生产成本.该工艺操作简单,得到产品三氟甲磺酸金属盐杂质含量低,优于行业标准,工艺过程零排放,具有很好的经济价值和社会价值.

    专利信息


    专利号:US-2024308959-A1
    优先权日:2021-06-29
    标 题:Processes for the preparation of (s)-2-(4-chloro-2-methoxyphenyl)-2-((3 -methoxy-5-(m ethylsulfonyl)phenyl)amino)-1 -(1h-indol-3-yl)ethenone derivatives
    发明人:WU KAI; OOST RIK; SCHWEITZER-CHAPUT BERTRAND; ERIKSSON CARL ARNE MAGNUS; COESEMANS ERWIN
    权利人:JANSSEN PHARMACEUTICALS INC
    摘要:The present invention relates to novel chiral synthesis of mono- or di-substituted indole compounds of formula (I) n n n n n n n n n n n n wherein: n R 1 is H, R 2 is F and R 3 is H or CH 3 , n R 1 is H, CH 3 or F, R 2 is OCH 3 and R 3 is H and n R 1 is H, R 2 is OCH 3 and R 3 is CH 3 , n R 1 is CH 3 , R 2 is F and R 3 is H, n R 1 is CF 3 or OCF 3 , R 2 is H and R 3 is H, n R 1 is OCF 3 , R 2 is OCH 3 and R 3 is H and n R 1 is OCF 3 , R 2 is H and R 3 is CH 3 .

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-11566004-B2
    优先权日:2018-07-23
    标题 :Process for the preparation of bromodomain inhibitor
    发明人:TRAVERSE JOHN FITZGERALD; YONG KELVIN HIN-YEONG; FERRETTI ANTONIO CHRISTIAN; ALITE HEKLA; MOSELEY JONATHAN; RUDA ANTONIO MARIA; PRIMER DAVID; PHILP STEVEN
    权利人:CELGENE QUANTICEL RES INC
    摘要:The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof. Embodiments of the disclosure relate to chemical synthesis routes of Compound 1 that provide a scalable method that results in highly pure final product. A further embodiment relates to methods to isolate the most stable polymorph of Compound 1 by crystallization from formic acid and water.

    专利号:WO-2025198684-A2
    优先权日:2023-12-20
    标题 :BaTiO3 NANOCRYSTALS AND NANOCOMPOSITES
    发明人:SZYCHOWSKI BRIAN; GELLEN TOBIAS A; WIACEK ROBERT J; MONICKAM SELINA THOMAS; WILLIAMS ZEHRA SERPIL GONEN; FU GUOYI
    权利人:PIXELLIGENT TECH LLC
    摘要:The synthesis of barium titanate nanocrystals, the capping of barium titanate nanocrystals to disperse into solvents, including polar and nonpolar solvents, polyalphaolefins, lubricants, oils, and greases, monomers, oligomers, and polymers including acrylics, epoxies, siloxanes, and the preparation of nanocomposites of barium titanate in combination with these monomers, oligomers, and polymers. The barium titanate nanocrystals are monodispersed with sizes between 1-200 nm and have an ideal barium to titanium ratio. The nanocrystals of size greater than 80 nanometer can possess high dielectric constants and can be ideal candidates of ceramic conductors and RF sensors. Nanocomposites resulting from the barium titanate nanocrystals of size less than 40 nanometer in combination with the monomers, oligomers, and polymers can possess high refractive index, high transparency, low absorbance, and minimal change when exposed to heat or UV light.

    专利号:US-9321713-B2
    优先权日:2011-06-03
    标 题:Hyperforin analogs, methods of synthesis, and uses thereof
    发明人:SHAIR MATTHEW D; SPARLING BRIAN A; MOEBIUS DAVID
    权利人:SHAIR MATTHEW D; SPARLING BRIAN A; MOEBIUS DAVID; HARVARD COLLEGE
    摘要:The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage.

    专利号:TW-201040144-A
    优先权日:2009-03-31
    标 题:New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
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    主要参考文献

    [参考文献]: Fumiya Urabe, Et Al. Total Synthesis Of (-)-Cinatrin C1 Based On An In(Otf)3-Catalyzed Conia-Ene Reaction. J Org Chem. 2013 Apr 19;78(8):3847-57.
    [参考文献]: Hua-Dong Xu, Et Al. One-Pot Protocol To Functionalized Benzopyrrolizidine Catalyzed Successively By Rh2(Oac)4 And Cu(Otf)2: A Transition Metal-Lewis Acid Catalysis Relay. Org Lett. 2015 Jan 2;17(1):66-9.
    [参考文献]: Krystyna Poreba, Et Al. The Synthesis Of 3,5,6,7-Tetrasubstituted Isoxazolo[参考文献]: Lihui Zhu, Et Al. In(Iii)/phco2H Binary Acid Catalyzed Tandem [参考文献]: Lingyong Jiang, Et Al. Silver Triflate-Catalyzed Tandem Reaction Of N'-(2-Alkynylbenzylidene)Hydrazide With Pyridyne. Org Biomol Chem. 2012 Oct 28;10(40):8102-7.

    合成参考文献


    摘要:Il'chenko, A. Y., Science of Synthesis, (2005) 18, 1169.
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