CAS: 57-87-4; (3S,9S,10R,13R,14R,17R)-17-((2R,5R,E)-5,6-Dimethylhept-3-En-2-yl)-10,13-Dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-3-Ol

上下游产品

CAS号474-67-9 菜籽甾醇 | CAS号2465-11-4 星鱼甾醇 | CAS号50-14-6 维生素D2 | CAS号21307-05-1 previtamin D2 | CAS号474-69-1 光甾醇 | CAS号115-61-7 速甾醇 | CAS号57-83-0 孕酮； 黄体素； 黄体酮 | CAS号24352-51-0 3,5-环麦角甾烷-6,8(1... | CAS号1108-03-8 3β-O-acetylergo...

22-Oxo-5α,8α-(4-Phenyl-3,5-Dioxo-1,2,4-Triazolidine-1,2-Diyl)-23,24-Dinor-6-Cholene-1α,3β-Diyl Diacetate置于吡啶,六甲基磷酰三胺,氢氧化钾,Sodium Tetrahydroborate,Disodium Hydrogenphosphate,Sodium Amalgam,Lithium Aluminium Tetrahydride,正丁基锂,乙醇,4-甲基苯磺酸吡啶,对甲苯磺酸,Sodium Iodide体系中,用 四氢呋喃,甲醇,乙醚,二氯甲烷 作为反应溶剂,化学反应 51.55H,反应生成 麦角固醇
参考文献:22,23-二氢-1α,25-二羟基维生素d2及其24R-差向异构体,新型维生素d2衍生物的合成
标题:22,23-二氢-1α,25-二羟基维生素d2及其24R-差向异构体,新型维生素d2衍生物的合成
摘要:新的 1α,25-二羟基维生素 D2 衍生物(22,23-二氢-1α,25-二羟基维生素 D2 (2A))及其 24R-差向异构体 (2B) 通过两种方法合成.22-Oxo-5α,8α-(4-Phenyl-3,5-Dioxo-1,2,4-Triazolidine-1,2-Diyl)-23,24-Dinor-6-Cholene-1α,3β-Diyl Diacetate (8) 可容易地从麦角甾醇中获得,转化为 22-苯基磺酰基-5α,8α-(4-苯基-3,5-二氧代-1,2,4-三唑烷-1,2-二基)-1α,3β-双(四氢吡喃氧基)-23,24-Dinor-6-Cholene (14) 或 22-Iodo-5α,8α-(4-Phenyl-3,5-Dioxo-1,2,4-Triazolidine-1,2-Diyl)-1α,3β-双(四氢吡喃氧基)-23,24-Dinor-6-Cholene (16).c-22
DOI:10.1246/bcsj.63.2233

专利信息

专利号:US-2004266699-A1
优先权日:2001-10-04
标 题 :Flavonoid compounds capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells, relative synthesis and their use
发明人：PORTA AMALIA
摘要:The invention relates to flavonoids compounds of formula (I) and (II) capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells. Such compounds are molecules of plant origin or synthetic. The invention also describes a method to identify, purify and chemically synthesize such flavonoid compounds and test their efficacy through their capacity to stimulate the transcription of stress genes and as a consequence, to interact with biological membranes with alteration of their relative physical state. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have applications in the areas of pharmaceuticals, more specifically in cosmetics and dermatology, for all those afections related to an alteration of the expression of stress genes.

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-2022267266-A1
优先权日:2019-07-09
标 题 :Improved, cost effective process for synthesis of vitamin d3 and its analogue calcifediol from ergosterol
发明人：DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; KADAM SACHIN VASANT
权利人:FERMENTA BIOTECH LTD
摘要:Disclosed herein is an improved and efficient process for synthesis of vitamin D3 and its analogue Calcifediol from Ergosterol. Particularly, the present invention discloses the synthesis of key intermediate 3β-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (5), and novel intermediate β-tert-Butyldimethylsilyloxy-22-iodo-23,24-bisnorchola-5,7-diene (9) by a simple and cost effective process. The industrially viable processes for preparation of said intermediate(s) results in providing provitamins with various side chains and the desired products in high yield.

专利号:US-5292977-A
优先权日:1992-02-05
标题:Palladium catalyzed alkylative cyclization useful in synthesis of vitamin D and analogues
发明人：TROST BARRY M; DUMAS JACQUES
权利人:UNIV LELAND STANFORD JUNIOR
摘要:An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R 1 where a substantially geometrically pure first precursor having the structure ##STR1## and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having the structure ##STR2## where R 2 hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R 3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.

专利号:US-6844461-B2
优先权日:2001-07-30
标 题:Synthesis of A-ring synthon of 19-NOR-1α,25-dihydroxyvitamin D3 from (D)-glucose
发明人：DELUCA HECTOR F; SHIMIZU MASATO; YAMADA SACHIKO
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (D)-glucose.

专利号:US-9994508-B2
优先权日:2012-12-11
标 题:Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives
发明人：LOPEZ PEREZ BORJA; SIGUEIRO PONTE RITA; MAESTRO SAAVEDRA MIGUEL A; MOURINO MOSQUERA ANTONIO
权利人:ENDOTHERM GMBH
摘要:Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.