CAS: 6002-40-0; Di-Tert-Butylmethylphosphine

该化合物是一种有机磷化合物,其特征是磷功能组,磷原子被捆绑在两个丁基组和一个甲基组之间,该化合物一般是无色的,可粉黄液,由于磷原子的存在,其强烈的核生殖特性为人所知.它与其他磷原子相比,其沸点相对较低,可使其挥发.二丁基甲基硫磷在化学和催化协调中经常被用作悬浮剂,特别是在与过渡金属有关的反应中.由于大丁基组,该化合物的僵化结构会影响金属复合体的再活动性和选择性.此外,必须小心处理这一化合物,因为磷可能是有毒的,如果吸入或摄入,可能会对健康造成危害.在实验室环境中与该物质打交道时,应当遵循适当的安全议定书.

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上下游产品

tri-tert-butyl phosphine borane-ammonia complexDi-tert.-butyl-methyl-(p-benzhydryl-phenyl)-phosphoniumbromid tri-tert-butyl phosphine diphenylphosphan(Di-tert-butylphosphino)methyldiphenylphosphan 1-[1-Chloro-2-(di-tert-butyl-phosphinoyl)-ethyl]-4-nitro-benzene

合成工艺路线路线简述

  • 合成目标产物 Di-T-Butylmethylphosphine 主要起始原料 Di-Tert-Butylchlorophosphane And Methylmagnesium Bromide
  • (文献来源)合成步骤主要原料 Di-Tert-Butylchlorophosphane 和 Methylmagnesium Bromide
二-叔丁基膦,碘甲烷 以 乙醚 作为反应溶剂,化学反应生成 二叔丁基甲基膦
参考文献:Hoffmann,H.; Schellenbeck,P.,Chemische Berichte,1966,Vol. 99,P. 1134-1142
标题:Hoffmann,H.; Schellenbeck,P.,Chemische Berichte,1966,Vol. 99,P. 1134-1142

专利信息


专利号:US-12049470-B2
优先权日:2021-02-01
标 题 :MK2 inhibitors, the synthesis thereof, and intermediates thereto
发明人:RUCHELMAN ALEXANDER L; COOMBS JOHN R; ZHU KEMING; LIM DANIEL; JOE CANDICE LEE; GEORGE DAVID T; ZHENG BIN; LIN DONG
权利人:CELGENE CORP
摘要:The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

专利号:US-11718584-B2
优先权日:2019-02-22
标题 :Process for the synthesis anthranilic diamide compounds and intermediates thereof
发明人:KARRI PHANEENDRASAI; PABBA JAGADISH; SHINDE BHARAT UTTAMRAO; KALWAGHE AMOL DNYANESHWAR; MADHAVRAO KAMBLE MARUTI; KLAUSENER ALEXANDER G M; PANMAND DEEPAK SHANKAR
权利人:PI INDUSTRIES LTD
摘要:The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), n n n n n n n n n n wherein, R 1 , R 2 , R 3a , R 3b , R 3c , R 4 , R 5 , R 6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va)

专利号:US-9273410-B2
优先权日:2009-01-16
标 题 :Low-temperature synthesis of colloidal nanocrystals
发明人:BARTL MICHAEL H; SIY JACQUELINE T
权利人:BARTL MICHAEL H; SIY JACQUELINE T; UNIV UTAH RES FOUND
摘要:Low-temperature organometallic nucleation and crystallization-based synthesis methods for the fabrication of semiconductor and metal colloidal nanocrystals with narrow size distributions and tunable, size- and shape-dependent electronic and optical properties. Methods include (1) forming a reaction mixture in a reaction vessel under an inert atmosphere that includes at least one solvent, a cationic precursor, an anionic precursor, and at least a first surface stabilizing ligand while stirring at a temperature in a range from about 50° C. to about 130° C. and (2) growing nanocrystals in the reaction mixture for a period of time while maintaining the temperature, the stirring, and the inert-gas atmosphere.

专利号:US-10457640-B2
优先权日:2016-10-19
标 题:Synthesis of inhibitors of EZH2
发明人:VASWANI RISHI G; HEWITT MICHAEL CHARLES
权利人:CONSTELLATION PHARMACEUTICALS INC
摘要:Provided herein are synthetic methods for the preparation of EZH2 inhibitors.

专利号:US-12172958-B2
优先权日:2021-05-19
标题:Synthesis of N-vinyl compounds by reacting NH-compounds with acetylene in presence of homogeneous phosphine catalyst
发明人:SCHAUB THOMAS; TUZINA PAVEL; BIENEWALD FRANK; MENCHE MAXIMILIAN; SITTE NIKOLAI AMADEUS; HASHMI A STEPHEN K
权利人:BASF SE
摘要:A process to produce N-vinyl compounds by homogeneous catalysis can be performed. Acetylene is reacted with a compound having at least one nitrogen bearing a substitutable hydrogen residue in a liquid phase in the presence of at least one phosphine as a catalyst to produce the compounds.

专利号:US-8114993-B2
优先权日:2007-02-06
标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization
发明人:DAUGULIS OLAFS; CHIONG HENDRICH
权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM
摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.
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合成参考文献


摘要:Zysman-Colman, E., Science of Synthesis, (2010) 45, 182.
摘要:Alonso, D. A.; Nájera, C., Science of Synthesis, (2010) 47, 447.
摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 63.
摘要:Black, D. A.; Fagnou, K., Science of Synthesis, (2010) 45, 638.
摘要:Negishi, E.; Wang, G., Science of Synthesis, (2010) 47, 937.
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