CAS: 676-98-2; Dichloro-Methyl-Sulfanylidene-λ5-Phosphane

上下游产品

methylphosphonic acid dichloroanhydride methyldichlorophosphanemethyl-thiophosphonic acid-dianilide Me(BuO)P(S)Cl dimethyl methylphosphonothionate O-ethyl methylchlorothiophosphonate

甲基膦酞二氯置于tetraphosphorus Decasulfide体系中,用62.2%的收率获得产物二氯甲基硫代膦
参考文献:在气相色谱/质谱分析条件下,Cwc相关异构的二烷基烷基硫代磷酸二烷基酯/硫代磷酸烷基酯的质谱表征.
标题:在气相色谱/质谱分析条件下,Cwc相关异构的二烷基烷基硫代磷酸二烷基酯/硫代磷酸烷基酯的质谱表征.
摘要:理由禁化武组织实施的<化学武器公约>(cwc)的列入清单的化学品列为异构的二烷基烷基硫代磷酸二烷基酯和烷基烷基膦酸二烷基酯.必须正确标识ps和pr键的连接性,以验证cwc.本研究证明了在电子电离(ei)或化学电离(ci)条件下通过选择性裂解成功鉴定目标异构体.方法在我们的实验室中,使用既定方法合成了所有研究的异构化合物(共27种),然后使用配备hp-5Ms毛细管柱的agilent 6890气相色谱仪通过ei和ci气相色谱/质谱(gc / Ms)进行分析并连接到5973 N质量选择检测器.使用范登杜尔公式计算所有化合物的保留指数(ri)值.还分别使用vg-Autospec(磁性扇区)和jeol-Accutof(飞行时间)质谱仪进行了gc / Ms / Ms和gc / Hrms实验.结果所有化合物的ei质谱在m / Z 182处均具有丰富的分子离子,除了少数几种丁基取代的化合物(该离子的丰度较
DOI:10.1002/rcm.6596

专利信息

专利号:US-6310198-B1
优先权日:1993-01-08
标题:Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
发明人：TANG JIN-YAN; BONGLE NANDKUMAR; GONZALEZ JOSE; SCHWARTZ WARREN E
权利人:AVECIA BIOTECHNOLOGY INC
摘要:The present invention comprises an improved method of synthesizing oligonucleotides. The method comprises employing dinucleotides (or 'dimer blocks') as the basic synthetic unit building block. The method results in extremely high purity oligonucleotides in which the N-1 content is very low, generally less than 1-2% of the full length, N, oligonucleotide. We have found that synthesis using dinucleotide phosphorothioates results in oligonucleotides having very little phosphodiester content. Furthermore, we have found that the amount of dimer required in each coupling step can be less than about 6 and is preferably about 2 equivalents. Synthesis of oligonucleotides according to the dimer block approach described herein can also be conducted without the capping step that has heretofore been deemed necessary after each coupling.

专利号:CN-106928271-B
优先权日:2017-02-20
标题:Method and device for continuous synthesis of O, O-dimethylphosphoryl thiochloride

专利号:CN-106928271-A
优先权日:2017-02-20
标题 :Continuous synthesis of O, O-dimethylphosphoryl thiochloride method and device thereof

专利号:RU-2144034-C1
优先权日:1993-07-02
标 题 :Derivatives of 1h-3-arylpyrrolidine-2,4-dione, parent and intermediate compounds for their synthesis and agent used for control of insects and mites injuring plants

专利号:CN-114213459-B
优先权日:2021-12-16
标 题:A continuous synthesis method of pirimiphos-methyl

专利号:RU-2195449-C2
优先权日:1995-06-28
标题:2,4,5-trisubstituted phenylketoenoles, intermediate compounds for their synthesis, method and agent for control of insects and spiders based on thereof