亚锑氢化物置于calcium Fluoride体系中,化学反应生成 三氟化锑 参考文献:Flueckiger,F. A.,Annalen Der Physik,1852,Vol. 87,P. 250 标题:Flueckiger,F. A.,Annalen Der Physik,1852,Vol. 87,P. 250
专利信息
专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-5196600-A 优先权日:1992-03-25 标题 :Synthesis of fluorinated dimethyl ethers 发明人:O'NEILL GERALD J 权利人:GRACE W R & CO 摘要:A novel process is disclosed for the synthesis of fluorinated dimethyl ethers of the formula CF 2 HOCCl x F y H 3- (x+y) wherein x is 0, 1 or 2; y is 1, 2 or 3; and wherein the total x+y is 1, 2 or 3. The process involves chlorination of methyl difluoromethyl ether to form a chlorinated reaction product, including at least one compound of the formula CF 2 HOCH 3-z Cl z , wherein z is 1, 2 or 3, which compound is then fluorinated with HF and/or an antimony salt and with or without separation from the chlorinated reaction product, to give a fluorinated reaction product including the aforementioned fluorinated dimethyl ethers.
专利号:US-5185474-A 优先权日:1990-10-02 标 题:Synthesis of fluorinated dimethyl ethers 发明人:O'NEILL GERALD J 权利人:GRACE W R & CO 摘要:A novel process is disclosed for the synthesis of fluorinated dimethyl ethers of the formula CF 2 HOCCl X F Y H 3- (X+Y) wherein X and Y are each independently 0, 1, 2 or 3 and wherein the total X+Y is 2 or 3. The process involves chlorination of methyl difluoromethyl ether to form a chlorinated reaction product, including at least one compound of the formula CF 2 HOCH 3-z Cl z , wherein z is 1, 2 or 3, which compound is then fluorinated, with or without separation from the chlorinated reaction product, to give a fluorinated reaction product including the aforementioned fluorinated dimethyl ethers.
专利号:US-4756739-A 优先权日:1985-12-21 标题 :Pyridine derivatives and the N-oxides thereof, and the use thereof as intermediates for the synthesis of plant protecting agents 发明人:FUSS ANDREAS; KOCH VOLKER 权利人:HOECHST AG 摘要:The compounds of the formula I (I) in which A denotes N or N->O, Z denotes O or NH, R denotes H, (halo)alkyl, (halo)alkenyl, (halo)alkynyl or alkoxycarbonyl, R1 denotes hydrogen, halogen, amino, -NHOH, hydroxyl, (substituted) phenylazo or a radical of the formulae Y=C=N-, Y1Y2C=N-, Y3NH- or K denotes 0 or 1, and m and n, independently of one another, denote a number from 1 to 4, with the proviso that, when Z-R denotes OH or NH2, (R1)n denotes at least one radical of the formula or represents two radicals, in the 5 or 6 position of the heterocyclic ring, which, in the 5 position, denote halogen and, in the 6 position, denote a radical of the group comprising halogen, amino, hydroxyl or phenylazo, which may be substituted as specified above, are valuable intermediates in the synthesis of plant protection agents.
专利号:US-2024368075-A1 优先权日:2021-07-02 标题 :Synthesis of N,N-Dialkyl, -Dialkenyl, -Dialkynyl, and Related Cyclics, Sulfamoyl Fluoride Compounds Using Hydrogen Fluoride 发明人:SINGH RAJENDRA P; HU QICHAO 权利人:SES HOLDINGS PTE LTD 摘要:Methods of producing N,N-dimethyl sulfamoyl fluoride and related derivatives of the formula F—S(O)2—NR2 (I) by contacting a sulfamoyl nonfluorohalide compound of the formula X—S(O)2—NR2 (II) with anhydrous hydrogen fluoride under conditions sufficient to produce the N,N-dimethyl sulfamoyl fluoride or derivative thereof of Formula I, wherein R in each of Formulas I and II is, independently, a linear or branched alkyl, alkenyl, or alkynyl group containing 1 to 12 carbon atoms, the Rs can be joined to form a cyclic amine with the N, and X is any one of chlorine, bromine, and iodine.
专利号:US-2023322661-A1 优先权日:2020-08-21 标题 :Synthesis of N,N-Branched Sulfamoyl Fluoride Compounds Using Bismuth Trifluoride 发明人:SINGH RAJENDRA P; HU QICHAO; SHEIMAN JOHNATHAN 权利人:SES HOLDINGS PTE LTD 摘要:Methods of producing N,N-branched sulfamoyl fluoride compounds of the formula F-S(O) 2 -NR 2 by contacting bismuth trifluoride with an N,N-branched sulfamoyl nonfluorohalide compound of the formula X-SO 2 NR 2 , wherein X=chlorine (Cl), bromine (Br), or iodine (I), and each R is, independently, a linear or branched alkyl, fluoroalkyl, alkenyl, fluoroalkenyl, alkynyl, or fluoroalkynyl with 1 to 12 carbon atoms, to fluorinate the N,N-branched sulfamoyl nonfluorohalide compound. This is a non-aqueous method, the purity of product is very high, and the desired product can be isolated in quantitative yield. The N,N-branched sulfamoyl fluoride compounds so produced are useful in various applications including as electrolyte solvents and additives in electrochemical devices, such as lithium batteries and capacitors, and in biological fields, among others.
摘要:Aitken, R. A.; Boubalouta, Y., Science of Synthesis Knowledge Updates, (2013) 4, 145. 摘要:de Vries, J. G., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 212. 摘要:Luckey, T.D. and B. Venugopal. Metal Toxicity in Mammals, 1. New York: Plenum Press, 1977., p. 179 摘要:Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3rd revised edition, Elsevier Mosby, St. Louis, MO 2007, p. 462-3 摘要:40 CFR 401.15 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of March 2, 2018: https://www.ecfr.gov