CAS: 791644-48-9; 2-Chloro-5-Fluoronicotinonitrile

上下游产品

CAS号75302-64-6 2-氯-5-氟烟酰胺 | CAS号851484-95-2 2-氯-5-氟吡啶-3-甲醛 | CAS号38186-88-8 2-氯-5-氟烟酸 | CAS号113237-20-0 2,6-二氯-3-甲酰胺-5-氟吡啶 | CAS号82671-02-1 3-氰基-2,6-二氯-5-氟吡啶 | CAS号82671-06-5 2,6-二氯-5-氟烟酸 | CAS号1034667-22-5 5-氟-1H-吡唑并[3,4-... | CAS号1256822-80-6 3-溴-5-氟-1H-吡唑并[...

2,6-二氯-5-氟烟酸置于palladium Diacetate,N,N-二甲基甲酰胺,三苯基膦 甲酸,草酰氯,三乙胺,三氟乙酸酐体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 1.5H,反应生成 2-氯-5-氟烟腈
参考文献:Aminopyrimidines Useful As Inhibitors Of Protein Kinases
标题:Aminopyrimidines Useful As Inhibitors Of Protein Kinases
摘要:本发明涉及用作蛋白激酶抑制剂的化合物.该发明还提供包含这些化合物的药用合适组合物,以及在治疗各种疾病,症状和障碍中使用这些化合物和组合物的方法.该发明还提供制备本发明化合物的方法.

专利信息

专利号:US-8598361-B2
优先权日:2007-07-31
标题 :Process for preparing 5-fluoro-1H-pyrazolo [3,4-B] pyridin-3-amine and derivatives therof
发明人：JIMENEZ JUAN-MIGUEL; MILLER ANDREW; COLLIER PHILIP; GREEN JEREMY; DROS ALBERT; GAO HUAI; HAMON SYLVAIN
权利人:JIMENEZ JUAN-MIGUEL; MILLER ANDREW; COLLIER PHILIP; GREEN JEREMY; DROS ALBERT; GAO HUAI; HAMON SYLVAIN; VERTEX PHARMA
摘要:The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.

专利号:US-2013211090-A1
优先权日:2010-09-03
标题:Method for the production of 5-fluoro-1h-pyrazolo[3,4-b]pyridine-3-carbonitrile
发明人：FOLLMANN MARKUS; ACKERSTAFF JENS
权利人:FOLLMANN MARKUS; ACKERSTAFF JENS; BAYER IP GMBH
摘要:The present invention relates to a process for preparing 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile of the formula (I) n n n n n n n n n n which serves as a synthesis intermediate for production of medicaments, especially for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.