CAS: 1022150-12-4; (R)-3-(4-Phenoxyphenyl)-1-(Piperidin-3-yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine

相似化合物

1553977-42-6 1022150-11-3 1288338-95-3

专利信息

专利号:US-2019040070-A1
优先权日:2016-02-09
标 题:Process for the synthesis of stable amorphous ibrutinib
发明人：MAIER THOMAS; KARAPETYAN INNA; ARAKELYAN ALVARD; MARGARYAN TAMARA; SARGSYAN VARDAN; STEPANYAN HEGHINE; ABOVYAN HERMINE; GERBER AESCHBACHER ROMAN; HAFERKAMP SVEN
权利人:AZAD PHARMACEUTICAL INGREDIENTS AG
摘要:Disclosed herein is a new route of synthesis and a new stable amorphous form of ibrutinib. Also disclosed are pharmaceutical compositions, oral dosage forms and the use of the amorphous ibrutinib in the treatment of mantle cell lymphoma or chronic lymphocytic leukemia.

专利号:WO-2020117135-A1
优先权日:2018-12-04
标 题:A process for preparation of 1h-pyrazolo[3,4-d] pyrimidine derivatives
发明人：HAAS PHILIPP DANIEL; STECKEL ANDREAS HARTWIG; BELLUR ATICI ESEN; ALTUNDAS RAMAZAN; OZTURK AYDIN BUSRA; SECEN HASAN; AYDIN BUSRA NUR
权利人:DEVA HOLDING AS
摘要:The present invention relates to an efficient and industrially advantageous process for the preparation of 1H-pyrazolo[3,4-d] pyrimidine derivatives. In particular the present invention provides a process for the preparation of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidine and tert-butyl (R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidin-1-yl)piperidine-1-carboxylate. Said compounds are important intermediates in the synthesis of ibrutinib. The method provided for preparing intermediates of ibrutinib has the advantages of a simple operation, high yield and low costs.

专利号:US-2018282336-A1
优先权日:2014-10-30
标题:Active Acrylamides
发明人：FELZMANN WOLFGANG; BRUNNER STEFANIE; LENGAUER HANNES
权利人:SANDOZ AG
摘要:The present invention refers to the synthesis and intermediates of substituted bicyclic compounds, which are used as a masked form of acrylamides and in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (ibrutinib) and its synthesis intermediates.

专利号:WO-2017137446-A1
优先权日:2016-02-09
标题:Process for the synthesis of stable amorphous ibrutinib

专利号:EP-3414248-A1
优先权日:2016-02-09
标题 :Process for the synthesis of stable amorphous ibrutinib

专利号:US-2019367518-A1
优先权日:2015-01-14
标题 :Synthesis of a bruton's tyrosine kinase inhibitor