Benzhydryl-3-Methylene-8-Oxo-7-Phenylacetamido-5-Thia-1-Azabicyclo[4,2,0]octane-2-Carboxylate置于水体系中,化学反应生成甲磺酸正丁酯 参考文献:Gubaidullin,M.G.; Kovaleva,L.M.,Journal Of General Chemistry Of The Ussr,1973,Vol. 43,P. 2638-2640 标题:Gubaidullin,M.G.; Kovaleva,L.M.,Journal Of General Chemistry Of The Ussr,1973,Vol. 43,P. 2638-2640
专利号:US-5541347-A 优先权日:1993-12-07 标 题 :Synthesis of bisindolylmaleimides 发明人:FAUL MARGARET M; JIROUSEK MICHAEL R; WINNEROSKI II LEONARD L 权利人:LILLY CO ELI 摘要:The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.
专利号:WO-2014027658-A1 优先权日:2012-08-13 标题 :INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES
专利号:US-2010137244-A1 优先权日:2006-07-13 标题 :Preparation and utility of hmg-coa reductase inhibitors 发明人:GANT THOMAS G; SARSHAR SEPEHR 权利人:AUSPEX PHARMACEUTICALS INC 摘要:Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of hypercholesterolemia, dyslipidemia, coronary artery disease, atherosclerosis, metabolic syndrome, a hyperproliferative disease such as colorectal cancer, prostate cancer, and melanoma, a neurodegenerative disease such as cerebral ischemia, Alzheimer's disease, and Parkinson's disease are described.
专利号:US-4352788-A 优先权日:1979-08-09 标题 :Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and X-ray contrasting materials containing these 发明人:FELDER ERNST; PITRE DAVIDE 权利人:BRACCO IND CHIMICA SPA 摘要:Compounds for use in non-ionic X-ray contrasting materials having the formula ##STR1## in which (H0) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxymethylisopropyl, n R is hydrogen or methyl, and n R 1 is an alkyl residue with 1 to 5 carbon atoms. n These compounds possess high water-solubility as well as excellent stability against hydrolysis. Methods for preparation and use of the compounds are also disclosed.
专利号:BR-112015003041-B1 优先权日:2012-08-13 标题 :METHODS OF PRODUCTION OF INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF 1-(2-DESOXY-2-FLUORO-4-THIO-SS-D-ARABINOFURANOSYL)CYTOSINE AND THIONUCLEOSIDE
专利号:JP-2000281611-A 优先权日:1999-03-30 标 题 :Synthesis of phenolic compound having protected hydroxy group, and radioactive ray-sensitive composition by using the same
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