CAS: 2410-93-7; (S)-2-(4-(((2-Amino-4-Oxo-3,4-Dihydropteridin-6-yl)Methyl)(Methyl)Amino)Benzamido)Pentanedioic Acid
- 英文名称(S)-2-(4-(((2-Amino-4-Oxo-3,4-Dihydropteridin-6-yl)Methyl)(Methyl)Amino)Benzamido)Pentanedioic Acid
- 中文名称氨甲叶酸杂质C
- IUPAC名称(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid
- 其它别名Methotrexate Ep Impurity C（amethopterin Ep Impurity C）; Methotrexate-Ep-Imp-C; L-Glutamic Acid,N-[4-[[(2-Amino-3,4-Dihydro-4-Oxo-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-; Methotrexate Ep Impurity C/methotrextae 4-Oxo Analog/n-Methylfolic Acid/(2S)-2-[[4-[[(2-Amino-4-Hydroxy Pteridin-6-yl)Methyl]Methyl Amino] Benzoyl]Amino]Pentanedioic Acid; Methotrexate Related Compound C; (2S)-2-[[4-[[(2-Amino-4-Hydroxy Pteridin-6-yl) Methyl] Methyl Amino] Benzoyl] Amino] Pentanedioic Acid; 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid; L-Glutamic Acid, N-[4-[[ (2-Amino-1, 4-Dihydro-4-Oxo-6-Pteridinyl)Meth Yl]Methylamino]Benzoyl]-
- CAS编号2410-93-7
- MFCD编号:MFCD30187666
- EINECS号:691-132-3
- 分子式:C20H21N7O6
- 分子量:455.43
- 产品CID: 1186334
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS08;
注释: Health hazard - 危险类别致癌性 类别2
致突变性 类别2
生殖毒性 类别2
生殖毒性 类别1B
急性毒性 类别3(经口)
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2 - 警示词Warning(警告)
- 危险描述H351 |怀疑致癌.
H341 |怀疑导致遗传缺陷.
H361 |怀疑对生育能力或胎儿造成损害.
H360 |可能损害生育能力或胎儿.
H301 |吞咽会中毒.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P201-P301+P310+P330-P302+P352-P305+P351+P338
- UN编号UN 2811 6.1 / PGIII
- WGK Germany3
欧盟法规
C&L通报上下游产品
CAS号59-05-2 甲氨蝶呤 | CAS号4271-30-1 N-(4-氨基甲酰)-L-谷氨酸 | CAS号38974-68-4 N-对碘苯甲酰-L-谷氨酸 | CAS号52980-68-4 N-[4-(甲基氨基)苯甲酰基... | CAS号1004-75-7 6-羟基-2,4,5-三氨基嘧啶 | CAS号5221-17-0 2,3-二溴丙醛合成工艺路线路线简述
甲氨蝶呤置于sodium Hydroxide体系中,化学反应生成2-[[4-[(2-氨基-4-氧代-1H-蝶啶-6-基)甲基-甲基氨基]苯甲酰基]氨基]戊烷二酸
参考文献:Analogs Of Pteroylglutamic Acid. Iii. 4-Amino Derivatives
标题:Analogs Of Pteroylglutamic Acid. Iii. 4-Amino Derivatives
摘要:
Doi:10.1021/ja01173A061
海关参考信息
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2905130000-正丁醇
2912110000-甲醛
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专利信息
专利号:US-6528631-B1
优先权日:1993-09-03
标题 :Oligonucleotide-folate conjugates
发明人：COOK PHILLIP DAN; MANOHARAN MUTHIAH; BHAT BALKRISHEN
权利人:ISIS PHARMACEUTICALS INC
摘要:Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage sites. The folate can be attached via the α- or γ-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed.
专利号:US-8044200-B2
优先权日:2005-03-16
标题 :Synthesis and purification of pteroic acid and conjugates thereof
发明人：XU LE-CUN; VLAHOV IONTCHO RADOSLAVOV; LEAMON CHRISTOPHER PAUL; SANTHAPURAM HARI KRISHNA; LI CHUNHONG
权利人:ENDOCYTE INC
摘要:Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also described. Purified forms of pteroic acid, derivatives and analogs of pteroic acid, and conjugates thereof are also described.
专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives
专利号:WO-2011123668-A2
优先权日:2010-03-31
标 题:Stereoselective synthesis of phosphorus containing actives
专利号:EP-2752422-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives
专利号:EP-2752422-B1
优先权日:2010-03-31
标题:Stereoselective synthesis of phosphorus containing actives
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主要参考文献
1: Li L, Wang JJ, Cheng JM. [Laparoscopic salpingotomy for tubal pregnancy: comparison of linear salpingotomy with and without suturing]. Zhonghua Yi Xue Za Zhi. 2016 Aug 9;96(30):2424-6. doi: 10.3760/cma.j.issn.0376-2491.2016.30.012. Chinese. doi: 10.1007/s00432-014-1720-5. Epub 2014 Jun 7. Chinese. Chinese. Chinese. Portuguese.
合成参考文献
参考文献:10.1007/s40519-019-00781-x
摘要:Portale S, Sculati M, Stanford FC, Cena H. Pellagra and anorexia nervosa: a case report. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity. 2019 Sep 17;25(5):1493–6. doi: 10.1007/s40519-019-00781-x.
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