CAS: 26961-27-3; 2-Amino-4,5-Dimethoxybenzonitrile

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CAS号102714-71-6 4,5-二甲氧基-2-硝基氰苯 | CAS号21575-13-3 6,7-二甲氧基喹唑啉-4-胺 | CAS号28888-44-0 6,7-二甲氧基-2,4-喹唑啉二酮 | CAS号19237-84-4 盐酸哌唑嗪 | CAS号27631-29-4 2,4-二氯-6,7-二甲氧基喹唑啉 | CAS号19216-56-9 哌唑嗪 | CAS号153436-54-5 4-[(3-溴苯基)氨基]-6... | CAS号67817-56-5 N-(2-cyano-4,5-... | CAS号90402-40-7 阿巴诺喹 | CAS号4765-46-2 1-(2-amino-4,5-...

4,5-二甲氧基-2-硝基苯甲腈置于sodium Dithionite,四丁基溴化铵体系中,用 二氯甲烷,水 用作溶剂,化学反应生成2-氨基-4,5-二甲氧基苯腈
参考文献:Identification Of 2,4-Diamino-6,7-Dimethoxyquinoline Derivatives As G9A Inhibitors
标题:Identification Of 2,4-Diamino-6,7-Dimethoxyquinoline Derivatives As G9A Inhibitors
摘要:为了发现新的g9A抑制剂化合物,我们已经确定了一种新的喹啉抑制剂骨架,并更好地定义了中心杂环的药效特征.
Doi:10.1039/c4Md00274A

专利信息

专利号:US-6080860-A
优先权日:1992-08-31
标 题:Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
发明人：KARIMIAN KHASHAYAR; MURTHY KESHAVA; HALL DARREN
权利人:BRANTFORD CHEMICALSS INC
摘要:Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

专利号:WO-2008084493-A3
优先权日:2007-01-09
标 题 :A novel process for the preparation of 2-halo-4-aminoquinazolines
发明人：BHOBE AJIT MADHUKAR; DAMLE SUBHASH VISHWANATH; ADHVARYU RUSHI DRUPADBHAI
权利人:UNICHEM LAB LTD; BHOBE AJIT MADHUKAR; DAMLE SUBHASH VISHWANATH; ADHVARYU RUSHI DRUPADBHAI
摘要:2-Halo-4-aminoquinazolines are produced by a one-step process involving intramolecular cyclization of appropriately substituted formamide derivatives in the presence of phosphorous oxyhalides. Exemplary of the process is the intramolecular cyclization of 3,4-dimethoxy-6-cyanoaniline-1-yl formamide in the presence of phosphorous oxychloride to 2-chloro-4-amino-6,7-dimethoxyquinazoline. These chemical compounds are utilized as intermediates in the preparation of some of the important antihypertensive agents e.g. 2-chloro-4-amino-6,7-dimethoxyquinazolines is used for the synthesis of alfuzosin hydrochloride.

专利号:WO-9405628-A1
优先权日:1992-08-31
标 题 :Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor

专利号:EP-0656885-A1
优先权日:1992-08-31
标 题 :Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor

专利号:CN-105130910-A
优先权日:2015-07-30
标 题 :A one-pot synthesis method of epidermal growth factor receptor tyrosine kinase inhibitor PD153035 and its analogs