CAS: 27333-47-7; 1,3,3-Trimethylspiro[indoline-2,3'-Naphtho[2,1-B][1,4]Oxazine]

上下游产品

1,3,3-Trimethyl-2-methyleneindoline 1-Nitroso-2-naphthol 1-[(Z)-1,3,3-Trimethyl-1,3-dihydro-indol-(2Z)-ylidenemethylimino]-1H-naphthalen-2-one mer°Cyanine 3,3-dimethyloxindole 1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one naphtho[1,2-d]oxazole 1,3,3-trimethylindoline carboxylic acid

1-氨基-2-萘酚盐酸盐置于二甲基亚砜,三乙胺体系中,用 甲醇,甲苯 用作溶剂,化学反应 20.0H,反应生成1,3,3-三甲基吲哚-奈谔嗪
参考文献:6'-氨基取代螺恶嗪的一锅法合成
标题:6'-氨基取代螺恶嗪的一锅法合成
摘要:通过 2-Methylene-1,3,3-Trimethylindoline 衍生物与 1-Amino-2 的缩合,一锅法合成 6'-氨基取代的螺吲哚啉萘 [2,1-B][1,4] 恶嗪-萘酚在不同的仲胺和氧化剂的存在下使用甲醇或甲苯作用作溶剂.该方法的主要优点是简单,并且从容易获得的试剂开始,它可以在温和的反应条件下以非常好的收率制备螺萘恶嗪的氨基衍生物.
Doi:10.1055/s-2005-870006

专利信息

专利号:US-2012100555-A1
优先权日:2009-06-29
标题 :Synthesis And Use Of Fluorophore-Tagged Antimalarials
发明人：LEAR MARTIN JAMES; TAN KEVIN SHYONG WEI
权利人:LEAR MARTIN JAMES; TAN KEVIN SHYONG WEI
摘要:This invention includes a fluorophore-tagged antimalarial represented by the following structural formula (1) or a salt thereof. This invention relates to the synthesis of fluorophore-tagged antimalarials and describes the synthesis of a fluorophore-tagged antimalarial. These fluorophore-tagged antimalarials can be used to image live cells to determine the location of the antimalarial in the cell, identify drug resistance and growth related pathways in Plasmodium isolates, identify new drug targets and chemo-sensitizers to reverse drug resistance.