CAS: 572-30-5; 3-(((2S,3R,4R,5S)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Oxy)-2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-4H-Chromen-4-One

该化合物是一种自然产生的花草胶胶质,主要存在于诸如出租车和多角形树脂等植物中,其化学结构包括与甘糖甘腐有关,有助于其生物活性特性的queceptin. 外阴素展示了显著的抗氧化剂,抗炎和潜在的抗癌活动,使其成为药理研究的一个主题. 它的蒸发自由基和调节细胞路径的能力凸显了它在研究氧化性压力相关条件方面的效用. 该化合物还因其生物利用率和代谢效应而受到调查. 外阴素的纯度和稳定性对于在体外和体外研究中可复制的实验结果至关重要.

结构式图片

上下游产品

CAS号10323-20-3 D-阿拉伯糖 | CAS号117-39-5 槲皮素 | CAS号5328-37-0 L-阿拉伯糖

合成工艺路线路线简述

    Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 扁蓄苷
    参考文献:Ohta,Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie,1940,Vol. 263,P. 221
    标题:Ohta,Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie,1940,Vol. 263,P. 221

    海关参考信息

    专利信息


    专利号:US-2002165207-A1
    优先权日:2001-05-02
    标题 :Compositions and methods for the treatment of diabetic neuropathy
    发明人:ROSENBLOOM RICHARD
    摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

    专利号:US-7914823-B2
    优先权日:2000-12-21
    标题 :Method and composition for the topical treatment of diabetic neuropathy
    发明人:ROSENBLOOM RICHARD ALLEN
    权利人:PROPHASE LABS INC
    摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

    专利号:US-12342841-B2
    优先权日:2020-09-28
    标题:Compositions for improving low testosterone levels
    发明人:AYYADURAI V A SHIVA; DEONIKAR PRABHAKAR
    权利人:CYTOSOLVE INC
    摘要:The present disclosure is related to dietary supplements. In some aspects, this disclosure relates to compositions that can include, one or more agents that can increase the synthesis of testosterone, decrease the degradation of testosterone, and/or decrease the oxidative stress. In some embodiments, an agent of the composition includes: a mineral, a carboxylic acid, a flavone, a flavan, a terpinoid, an amino acid, a benzopyran; and a glycoside, and a combination thereof.
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    主要参考文献


    1: Zou ZL, Sun MH, Yin WF, Yang L, Kong LY. Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation. Phytomedicine. 2021 Oct;91:153657. doi: 10.1016/j.phymed.2021.153657. Epub 2021 Jul 12. 40(1):140-153. doi: 10.1007/s12640-021-00467-2. Epub 2022 Jan 18. 24(2):232-239. doi: 10.22038/ijbms.2020.49770.11368.
    4: Wang Z, Li F, Quan Y, Shen J. Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF‑κB/COX‑2/PPAR‑γ activities. Mol Med Rep. 2019 Jun;19(6):5417-5423. doi: 10.3892/mmr.2019.10198. Epub 2019 Apr 25.
    5: Zhang Z, Lv G, Du L. Avicularin Reduces the Expression of Mediators of Inflammation and Oxidative Stress in Bradykinin-Treated MG-63 Human Osteoblastic Osteosarcoma Cells. Med Sci Monit. 2020 May 28;26:e921957. doi: 10.12659/MSM.921957.

    合成参考文献


    参考文献:10.1021/np960057s
    摘要:Lale A, Herbert JM, Augereau JM, Billon M, Leconte M, Gleye J. Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes. J Nat Prod. 1996 Mar;59(3):273–6. doi: 10.1021/np960057s.
    参考文献:10.1021/jf030459n
    摘要:Chinnici F, Gaiani A, Natali N, Riponi C, Galassi S. Improved HPLC determination of phenolic compounds in cv. golden delicious apples using a monolithic column. J Agric Food Chem. 2004 Jan 14;52(1):3–7. doi: 10.1021/jf030459n.
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