CAS: 7254-19-5; 5-Bromo-1H-Indole-2-Carboxylic Acid

上下游产品

CAS号16732-70-0 5-溴吲哚-2-羧酸乙酯 | CAS号66416-72-6 4 -溴- 2-碘苯甲胺 | CAS号127-17-3 丙酮酸 | CAS号17403-17-7 (5-bromo-2-nitr... | CAS号53590-48-0 2-羟甲基-5-溴-1H-吲哚 | CAS号53590-50-4 5-溴吲哚-2-甲醛 | CAS号10075-50-0 5-溴吲哚 | CAS号1670-81-1 吲哚-5-羧酸 | CAS号210345-56-5 5-溴吲哚-2-甲酸甲酯 | CAS号15861-24-2 5-氰基吲哚 | CAS号16732-70-0 5-溴吲哚-2-羧酸乙酯 | CAS号736990-02-6 2-乙氧基羰基吲哚-5-硼酸频那醇酯

Ethyl 2-[2-(4-Bromophenyl)Hydrazinylidene]Propanoate置于磷酸,Sodium Hydroxide体系中,用 甲醇,水 作为反应溶剂,化学反应 1.83H,反应生成 5-溴吲哚-2-羧酸
参考文献:取代吲哚-2-甲酸的合成方法
标题:取代吲哚-2-甲酸的合成方法
摘要:本发明公开一种取代吲哚‑2‑甲酸的合成方法,是以取代苯肼盐酸盐或苯肼为原料,经过与丙酮酸乙酯成腙,再经fischer吲哚合成反应得到取代吲哚‑2‑甲酸乙酯,水解后得到取代‑2‑甲酸.产品纯度大于97%,反应收率64%.本发明的合成方法具有无苛刻条件,操作简单,对环境友好的特点,具有一定的经济效益.是一种原料易得,操作简便,三废少,高收率的吲哚‑2‑甲酸合成方法.

专利信息

专利号:US-6429311-B2
优先权日:1997-12-15
标 题:Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof
发明人：GAO YUN
权利人:SEPRACOR INC
摘要:The present invention is directed to certain N-amino- and N-hydroxy-quinazolinone compounds and synthetic methods for synthesis thereof, which compounds may find use in combinatorial libraries. More specifically, the invention is directed to the synthesis of 3-hydroxy- and 3-amino-4 (1H)-quinazolinones via the reaction of an appropriate 2-aminobenzamide compound with a carboxylic acid or acyl halide at ambient temperature performed on a solid support or in solution.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-12365682-B2
优先权日:2022-12-19
标 题 :Process to make GLP1 RA and intermediates therefor
发明人：ALLIAN AYMAN D; BERGLUND KENNETH DEREK; COLE KEVIN PAUL; DAVIS ASHLEE JEANETTE; HESS MOLLY; JEMISON ADRIANA; KERR MARK STEVEN; MACK AUDREY GRACE; ORTIZ-MEDINA XAVIER A; REMICK DAVID MICHAEL; STARKEY DEREK ROBERT; VAID RADHE KRISHAN; YANG QIANG; KAWAGISHI FUMIKI; EMURA TAKASHI; TSUCHIYA SATOSHI; WADAMOTO MANABU; YAMAWAKI MINORU
权利人:LILLY CO ELI; CHUGAI PHARMACEUTICAL CO LTD
摘要:The present invention relates to the synthesis of 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl ]-4-methyl-6,7-dihydro-4H-pyrazolo [4,3-c] pyridine-5-carbonyl] indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a salt thereof, and related synthetic intermediate compounds.

专利号:US-6989384-B2
优先权日:2000-06-14
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：HUA YE; LUU HIEP THE; CHAN FORA P; JOHNSON JR THEODORE O; REICH SIEGFRIED HEINZ; SKALITZKY DONALD JAMES; YANG YI; HENDRICKSON THOMAS F; CHU SHAO SONG; EASTMAN BRIAN WALTER
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-2024327418-A1
优先权日:2021-08-04
标 题 :Multi-target inhibitor targeting hdac and nad synthesis and use of multi-target inhibitor

专利号:WO-2023011416-A1
优先权日:2021-08-04
标题:Multi-target inhibitor targeting hdac and nad synthesis and use of multi-target inhibitor