CAS: 85006-21-9; 2-Chloro-5-Methoxyaniline Hydrochloride

专利信息

专利号:US-9220795-B2
优先权日:2011-09-22
标题 :Indole derivatives
发明人：WADSWORTH HARRY JOHN; O'SHEA DENNIS; PASSMORE JOANNA; TRIGG WILLIAM; EEWAN AMANDA; SHAN BO
权利人:GE HEALTHCARE LTD
摘要:An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.

专利号:US-8790619-B2
优先权日:2009-03-27
标题 :Indole derivatives
发明人：WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN; EWAN AMANDA
权利人:WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN; EWAN AMANDA; GE HEALTHCARE LTD
摘要:An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.