CAS: 87-25-2; Ethyl Anthranilate

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CAS号64-17-5 乙醇 | CAS号118-92-3 邻氨基苯甲酸 | CAS号6091-64-1 2-溴苯甲酸乙酯 | CAS号118-48-9 靛红酸酐 | CAS号610-34-4 2-硝基苯甲酸乙酯 | CAS号865873-29-6 ethyl 2-(allyla... | CAS号552-16-9 2-硝基苯甲酸 | CAS号86451-26-5 Phenyliodine(II... | CAS号134-20-3 邻氨基苯甲酸甲酯 | CAS号5081-87-8 3-(2-氯乙基)-2,4(1... | CAS号35472-56-1 2-(甲基氨基)苯甲酸乙酯 | CAS号55426-74-9 2-二甲基氨基苯甲酸乙酯 | CAS号5471-20-5 2-氨基-N-苄基苯甲酰胺 | CAS号148673-97-6 2-(2,4-dioxo-1,... | CAS号143049-22-3 2,4-dioxo-1H-qu... | CAS号40059-53-8 2,4-二羟基喹啉-3-甲酸乙酯 | CAS号1769-25-1 2,3-二甲基-3H-喹唑啉-4-酮 | CAS号1769-24-0 2-甲基-4(1H)-喹唑啉酮 | CAS号90-16-4 3,4-二氢-4-氧-1,2,...

邻硝基苯甲酸置于硫酸,Palladium On Activated Charcoal,氢气体系中,用 甲醇,乙酸乙酯 作为反应溶剂,化学反应 84.0H,反应生成 2-氨基苯甲酸乙酯
参考文献:寨卡病毒抑制剂新系列n-酰基-2-氨基苯并噻唑的发现及结构优化
标题:寨卡病毒抑制剂新系列n-酰基-2-氨基苯并噻唑的发现及结构优化
摘要:寨卡病毒感染与先天性小头畸形和寨卡热等严重疾病有关,对人类造成严重伤害,特别引起低收入国家卫生系统的关注.目前,尚无针对该病毒的批准药物,因此开发抗寨卡病毒药物刻不容缓.目前的研究描述了抗寨卡病毒复制的n-酰基-2-氨基苯并噻唑系列化合物的发现和命中扩展.通过合成和评价 19 种衍生物的抗寨卡病毒活性和对 Vero 细胞的细胞毒性,获得了构效关系研究.三种优化化合物的效力比初始化合物强 2.2 倍,选择性分别高 20.9,7.7 和 6.4 倍.随后进行表型和生化测定,以证明非结构蛋白(例如复合物 Ns2B-Ns3Pro)是否与最活性化合物的作用机制有关.
DOI:10.1016/j.Bmc.2023.117488

专利信息

专利号:EP-1431274-B1
优先权日:2002-12-18
标题 :Synthesis of mono-N-substituted functionalized anilines
发明人：SELVA MAURIZIO; TUNDO PIETRO
权利人:CONSORZIO INTERUNIVERSITARIO N
摘要:The present invention relates to a process for direct and selective synthesis of mono-N-substituted functionalized anilines by using alkylating agents selected from the class of organic carbonates, preferably of the dialkyl, dibenzyl and diallyl types, in the presence of suitable catalysts that are chemically related to the class of aluminosilicates.

专利号:WO-2025073852-A3
优先权日:2023-10-03
标题:Enzymatic synthesis of glycosylated anthranilate derivatives
发明人：HEDEDAM WELNER DITTE; NAHUEL BIDART COSTOYA GONZALO; GHARABLI HANI
权利人:UNIV DANMARKS TEKNISKE
摘要:The present invention concerns enzymatic synthesis of glycosides of anthranilate derivatives, such as methyl anthranilate N-glucoside, ethyl anthranilate N-glucoside, and butyl anthranilate N-glucoside. These anthranilate derivatives may preferably be used as insect and/or bird repellent.

专利号:US-10947344-B2
优先权日:2016-10-13
标题:Route for the synthesis of statistical, aliphatic-aromatic copolyamides, and the resulting statistical, aliphatic-aromatic copolyamides
发明人：CARLOTTI STÉPHANE; BAKKALI-HASSANI CAMILLE; ROOS KÉVIN; PLANES MIKAEL
权利人:UNIV BORDEAUX; INST POLYTECHNIQUE BORDEAUX; CENTRE NAT RECH SCIENT
摘要:The present invention relates to a novel synthesis route that can be used to access novel statistical, aliphatic-aromatic copolyamides, by means of ring-opening polymerisation and chain-growth polycondensation, as well as to the resulting copolymers.

专利号:US-6849735-B1
优先权日:2000-06-23
标 题:Methods of synthesis for 9-substituted hypoxanthine derivatives
发明人：GLASKY ALVIN J; BOLLINGER HEINRICH; MUELLER HANS RUDOLF
权利人:MERCK EPROVA AG
摘要:An improved method of synthesis of a 9-substituted hypoxanthine derivative comprises the steps of: (1) reacting aminocyanacetamide with triethyl orthoformate to form an imidoester derivative of aminocyanacetamide; (2) forming a compound having a reactive amino group on a hydrocarbyl moiety, the hydrocarbyl moiety being linked through an amide group to a physiologically active moiety or an esterified derivative of a physiologically active moiety including therein an esterified benzoyl group; (3) reacting the imidoester with the compound having the reactive amino group on the hydrocarbyl moiety to form a derivative of aminoimidazole-4-carboxamide substituted at the 1-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; (4) forming the six-membered heterocyclic ring of the purine moiety of the hypoxanthine by reacting the derivative of 5-aminoimidazole-4-carboxamide formed in step (3) with triethyl orthoformate to form a 9-substituted hypoxanthine compound substituted at the 9-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; and (5) hydrolyzing the ester of the optionally esterified benzoyl group if present.

专利号:US-9440948-B2
优先权日:2010-09-03
标题:Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use
发明人：KEM WILLIAM READE; SOTI FERENC; ROUCHAUD ANNE; XING HONG; LINDSTROM JON; ANDRUD KRISTIN MARIE
权利人:KEM WILLIAM READE; SOTI FERENC; ROUCHAUD ANNE; XING HONG; LINDSTROM JON; ANDRUD KRISTIN MARIE; UNIV FLORIDA; UNIV PENNSYLVANIA
摘要:Embodiments of the present disclosure provide for compounds such as those shown in FIG. 1.1 (compounds A, B, C, and D), 2′substituted nicotine compounds, azetidine compounds, ether linked nicotine compounds (FIG. 1.2 , compounds E, F, G, and H), methods of synthesis of the compounds, methods of treatment of a condition using compounds A, B, C, D, 2′substituted nicotine compounds, azetidine compounds, or ether linked nicotine compounds, methods of selectively stimulating alpha7 nAChR and/or alpha4beta2 receptors, and the like.

专利号:US-9365532-B1
优先权日:2011-02-14
标题:Synthesis, composition and use of novel therapeutic and cosmetic Schiff base products formed by reaction of a carbonyl containing moeity with a transimination nucleophilic catalyst and the use of transimination nucleophilic catalysts to increase the rate at which carbonyl containing therapeutic and cosmetic actives form Schiff base products with biological amines
发明人：ISAACMAN STEVEN
权利人:ISAACMAN STEVEN; NANOMETICS LLC
摘要:The present invention relates to the synthesis, composition and use of novel moieties formed by reacting a transimination nucleophilic catalyst, molecular or polymeric, with carbonyl-containing therapeutic or cosmetic moieties. The resultant Schiff base product is highly reactive towards transimination with a biological amine. The catalyst and carbonyl-containing moiety can be molecular or polymeric, and the resultant chemical and physical properties of the Schiff base products can be engineered by appropriate selection of said catalyst. The present invention also relates to the synthesis, composition and use of novel moieties that are used as actives in sunless tanning preparations. The present invention also relates to the use of transimination nucleophilic catalysts to increase the rate at which a carbonyl-containing moiety reacts with a biological amine. The present invention also relates to the use of transimination nucleophilic catalysts to increase the rate and efficacy of commercial sunless tanning preparations. Improvements on stability and efficacy of said preparations are disclosed. While the invention has been described in terms of its preferred embodiments, those skilled in the art will recognize that the invention can be practiced with modification within the spirit and scope of the appended claims. Accordingly, the present invention should not be limited to the embodiments as described above, but should further include all modifications and equivalents thereof within the spirit and scope of the description provided herein.