CAS: 17261-28-8; 2-(Diphenylphosphino)Benzoic Acid

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CAS号16463-38-0 邻氯苯甲酸钾 | CAS号1079-66-9 氯代二苯基膦 | CAS号917-64-6 甲基碘化镁 | CAS号370868-02-3 (-)-(S,E)-3-[2-... | CAS号17264-74-3 2-氯苯甲酸钠 | CAS号15475-27-1 二苯基磷酸钾 | CAS号16463-37-9 potassium ortho... | CAS号79932-99-3 2-(二苯基膦基) -苯甲酸甲酯 | CAS号88-67-5 邻碘苯甲酸 | CAS号829-85-6 二苯基膦 | CAS号146583-33-7 diphenyl-[2-(py... | CAS号291286-47-0 (2,5-dioxopyrro... | CAS号138517-61-0 (1R,2R)-(+)-1,2... | CAS号177263-77-3 2-二苯基膦苄胺 | CAS号659727-33-0 2-diphenylphosp... | CAS号68718-85-4 1-(bromomethyl)... | CAS号68718-89-8 (2-diphenylphos... | CAS号79932-99-3 2-(二苯基膦基) -苯甲酸甲酯

水杨酸甲酯置于1,2-双(二苯基膦)乙烷氯化镍 吡啶,Lithium Hydroxide,锌体系中,用 四氢呋喃,二氯甲烷,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 30.0H,反应生成2-二苯基膦苯甲酸
参考文献:具有反式1,2-二氨基环己烷主链的新型杂合配体:钯催化的对映选择性烯丙基烷基化反应中的竞争螯合模式
标题:具有反式1,2-二氨基环己烷主链的新型杂合配体:钯催化的对映选择性烯丙基烷基化反应中的竞争螯合模式
摘要:从(1R,2R)-2-氨基环己基氨基甲酸叔丁酯(4)合成了三个具有反式1,2-二氨基环己烷骨架的新杂配体,该酯是通过对二胺的间接单保护而制备的.配体是(1R,2R)-N-2-[2-(二甲基氨基)苯甲酰基]氨基环己基-2-(二苯基磷基苯甲基)苯甲酰胺及其二正丁基氨基和二苯基氨基衍生物(3A-C),在金属螯合中可能具有较大的咬合角,从而形成正式的p,N型螯合物.为了评估针对已知的p,N-和p,P-螯合物(1和2)的新型杂合配体,将它们用于钯催化的两种标准外消旋烯丙基乙酸酯2-乙酰氧基-1,3之间的烯丙基烷基化反应.-二苯基-2-丙烯(14A)和2-乙酰氧基-1,3-二甲基-2-丙烯(14B)和丙二酸二甲酯在不同的反应条件下.具有新配体的催化体系对具有适度对映选择性的两种底物均表现出非常好的反应性(对14A的ee高达78%ee,对14B的ee高达80%).特别值得注意的是,根据配体和反应条件,
Doi:10.1021/jo000821M

专利信息

专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

专利号:US-9422232-B2
优先权日:2009-07-09
标题:Reductive release probes containing a chemoselectively cleavable α-azidoether linker and methods of use thereof
发明人：FRANZINI RAPHAEL M; KOOL ERIC TODD
权利人:FRANZINI RAPHAEL M; KOOL ERIC TODD; UNIV LELAND STANFORD JUNIOR
摘要:Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.

专利号:US-8273403-B2
优先权日:2002-05-10
标题 :Generation of surface coating diversity
发明人：BARDEN MICHAEL C; KAMBOURIS PETER A
权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD
摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.

专利号:US-2011282075-A1
优先权日:2010-05-14
标题 :Method for preparing vittatalactone
发明人：BREIT BERNHARD
权利人:BREIT BERNHARD; UNIV ALBERT LUDWIGS FREIBURG
摘要:The present invention relates to the chemical synthesis of vittatalactone, the aggregation pheromone of the striped cucumber beetle, Acalymma vittatum.

专利号:US-2011077426-A1
优先权日:2008-12-12
标 题:Method for synthesis of o-diphenylphosphinobenzoic acid

专利号:US-5602267-A
优先权日:1995-05-26
标 题 :Organometallic catalysts for epoxidizing prochiral olefins and a new class of amid-salicylidene ligands
发明人：ZHAO SHU-HAI
权利人:HOECHST CELANESE
摘要:Asymmetric synthesis using a novel catalyst comprising the formula: and which has utility in areas such as epoxidation of olefins.