CAS: 20780-54-5; (S)-2-Phenyloxirane

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CAS号40435-14-1 (S)-(+)-1-苯基-1,... | CAS号532-27-4 2-氯苯乙酮 | CAS号292638-84-7 phenylene-ethylene | CAS号70111-05-6 (S)-(+)-2-氯-1-苯乙醇 | CAS号96-09-3 氧化苯乙烯 | CAS号1155277-45-4 trimethyl[(2R,3... | CAS号70-11-1 2-溴苯乙酮 | CAS号103665-43-6 (S)-1-acetoxy-1... | CAS号2425-28-7 1-苯基-2-溴乙醇 | CAS号100-52-7 苯甲醛 | CAS号17628-72-7 (R)-(-)-2-甲氧基-3-苯乙醇 | CAS号66051-01-2 (S)-(+)-2-甲氧基-3-苯乙醇 | CAS号93-56-1 (±)-1-苯基-1,2-乙二醇 | CAS号93-54-9 1-苯基-1-丙醇 | CAS号1123-85-9 2-苯基-1-丙醇 | CAS号60-12-8 苯乙醇 | CAS号1445-91-6 (S)-(-)-1-苯基乙醇 | CAS号16355-00-3 (R)-(-)-1-苯基-1,2-乙二醇 | CAS号25779-13-9 (S)-1-苯基-1,2-乙二醇 | CAS号56613-81-1 (|S|)-2-氨基-1-苯乙醇

Alpha-氯乙酰苯置于(S)-3,3-Diphenyltetrahydro-3H-1L4-Spiro[pyrrolo[1,2-C][1,3,2]Oxazaborole-1,2'-[1,3,2]Dioxaborolane],Dimethyl Sulfide Borane,Sodium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,化学反应 2.5H,反应生成(S)-环氧苯乙烷
参考文献:螺硼酸酯催化硼烷还原 2-卤代酮制备手性环氧化物:在光学纯 1,2-羟基醚和 1,2-叠氮醇合成中的应用
标题:螺硼酸酯催化硼烷还原 2-卤代酮制备手性环氧化物:在光学纯 1,2-羟基醚和 1,2-叠氮醇合成中的应用
摘要:描述了以 10% 螺氨基硼酸酯1作为催化剂,对映选择性硼烷介导的多种 2-卤代酮的还原反应.通过 2-卤代醇的简单基础处理,可以高产率和优异的对映体纯度(高达 99% Ee)获得光学活性环氧化物.在不同的反应条件下研究了环氧乙烷与酚盐或叠氮化钠的开环,得到具有优异对映选择性 (99% Ee) 和非常好至高化学收率的非外消旋 1,2-羟基醚和 1,2-叠氮醇.
Doi:10.1021/jo102294J

专利信息

专利号:US-9150840-B2
优先权日:2011-08-26
标题 :Isolated bacterial strain of Achromobacter sp. MTCC 5605 and a highly enantioselective epoxide hydrolase isolated therefrom
发明人：KAMAL AHMED; KHANNA ROHINI; KUMAR CHITYAL GANESH; SHAIK ANVER BASHA; KUMAR MATAM SHIVA
权利人:KAMAL AHMED; KHANNA ROHINI; KUMAR CHITYAL GANESH; SHAIK ANVER BASHA; KUMAR MATAM SHIVA; COUNCIL SCIENT IND RES
摘要:The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invention further relates to a new bacterial strain Achromobacter sp. MTCC 5605 isolated from a petroleum-contaminated sludge sample, capable of producing the said enzyme. It is notable that the enzyme can be used as whole bacterial cell preparation, which allows continuous hydrolysis of substrates at even higher concentration and have an advantage of being recycled. The invention further relates to a process for the hydrolysis of different aryl epoxides which are potential synthons of intermediates for the synthesis of chiral amino alcohols and bioactive compounds like β-blockers.

专利号:US-2009182016-A1
优先权日:2006-05-23
标题 :Optical enantiomers of phenyramidol and process for chiral synthesis
发明人：DATLA ANUPAMA; WALAVALKER PRAMOD ABAJI; KONDA ASHOK; TRIVIKRAM SREENATH BABUNATH
权利人:DATLA ANUPAMA; WALAVALKER PRAMOD ABAJI; KONDA ASHOK; TRIVIKRAM SREENATH BABUNATH
摘要:The present invention discloses optically pure (R) and (S) Phenyramidol enantiomers and their pharmaceutically acceptable salts, a process for synthesising such enantiomers by means of a styrene oxide based asymmetric synthesis, and also a clinical evaluation of (R) and (S) enantiomers of Phenyramidol, their salts and compositions thereof for enhanced/newer therapeutic benefits.

专利号:US-8389551-B2
优先权日:2006-05-23
标题:Optical enantiomers of phenyramidol and process for chiral synthesis
发明人：DATLA ANUPAMA; WALAVALKER PRAMOD ABAJI; KONDA ASHOK; TRIVIKRAM SREENATH BABUNATH
权利人:DATLA ANUPAMA; WALAVALKER PRAMOD ABAJI; KONDA ASHOK; TRIVIKRAM SREENATH BABUNATH; FERMENTA BIOTECH UK LTD
摘要:The present invention discloses optically pure (R) and (S) Phenyramidol enantiomers and their pharmaceutically acceptable salts, a process for synthesizing such enantiomers by means of a styrene oxide based synthesis, and also a clinical evaluation of (R) and (S) enantiomers of Phenyramidol, their salts and compositions thereof for enhanced/newer therapeutic benefits.

专利号:EP-3177589-A1
优先权日:2014-08-06
标题 :Method for the synthesis of mirabegron and its derivatives

专利号:EP-3008197-A2
优先权日:2013-06-13
标题 :Method for biocatalytic synthesis of substituted or unsubstituted phenylacetic acids and ketones having enzymes of microbial styrene degradation

专利号:US-2016186217-A1
优先权日:2013-06-13
标 题 :Method for biocatalytic synthesis of substituted or unsubstituted phenylacetic acids and ketones having enzymes of microbial styrene degradation