CAS: 38585-74-9; Thiazol-5-Ylmethanol

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CAS号32955-22-9 噻唑-5-甲酸乙酯 | CAS号14527-44-7 5-噻唑甲酸甲酯 | CAS号170232-68-5 2,4-二溴噻唑-5-甲醇 | CAS号1003-32-3 5-噻唑甲醛 | CAS号145015-15-2 2-氯-5-羟基甲基噻唑 | CAS号170232-69-6 2,4-二氯-5-噻唑甲醇 | CAS号262444-15-5 4-溴-5-羟甲基噻唑 | CAS号45438-77-5 5-氯甲基噻唑 | CAS号1003-32-3 5-噻唑甲醛 | CAS号144163-97-3 ((5-噻唑基)甲基)-(4-... | CAS号167998-61-0 5-溴甲基噻唑 | CAS号933751-05-4 N-甲基(噻唑-5-基)甲胺 | CAS号50382-34-8 1,3-Thiazol-5-y...

5-噻唑甲醛置于sodium Tetrahydroborate体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以75%的收率获得产物5-羟甲基噻唑
参考文献:Synthesis And Properties Of Nlo Chromophores With Fine-Tuned Gradient Electronic Structures
标题:Synthesis And Properties Of Nlo Chromophores With Fine-Tuned Gradient Electronic Structures
摘要:本研究设计并合成了一系列基于杂环的新型 Nlo 发色团,这些发色团基于不同的辅助给体(即苯,噻吩和吡咯)和辅助受体(即具有不同化学结构的噻唑)组合.由于辅助供体和受体分别具有不同的富电子性和贫电子性,所得到的 Nlo 发色团具有系统的不同基态电子结构,1H NMR,Cv 和 Uv-Vis 研究证明了这一点.通过紫外-可见光谱,超雷利散射(hrs)和半经验计算研究了所得 Nlo 发色团的非线性光学特性.所有发色团在 704-1500 x 10-30 Esu(或 β0,318-768 x 10-30 Esu)范围内都具有非常大的分子超极化率(β1000 Nm),这表明它们对梯度电子结构非常敏感.当电子密度从苯增加到噻吩和吡咯时,β0 显著增加;基于 "匹配 "噻唑(c2 连接到受体)的 Nlo 发色团的β0 值也明显大于基于 "非匹配 "噻唑(c5 连接到受体)的 Nlo 发色团.热重分析表明,所制备的 Nlo 发色团具有非常好的热稳定性.然而,随着辅助供体电子密度的增加,热稳定性和光化学稳定性都有所下降.值得注意的是,以三芳基胺为供体,噻唑为辅助受体的 Nlo 发色团不仅具有很高的热稳定性,而且β0 值也非常大.
DOI:10.1039/b817789A

专利信息

专利号:JP-H1087639-A
优先权日:1992-12-29
标题:Useful intermediates for the synthesis of compounds that inhibit retroviral protease

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:WO-2010065383-A1
优先权日:2008-11-25
标 题 :Calcilytic compounds
发明人：CASILLAS LINDA N; CHARNLEY ADAM KENNETH; HARRIS PHILIP ANTHONY; JEONG JAE U; MARQUIS ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT
权利人:GLAXOSMITHKLINE LLC; CASILLAS LINDA N; CHARNLEY ADAM KENNETH; HARRIS PHILIP ANTHONY; JEONG JAE U; MARQUIS ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

专利号:US-7645786-B2
优先权日:2005-06-15
标题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:RU-2049782-C1
优先权日:1989-04-24
标 题:Thiazole derivatives, method of their synthesis, method of struggle against fungi