CAS: 39178-35-3; Isonicotinoyl Chloride Hydrochloride

相似化合物

872-85-5 1822-51-1 1122-54-9

上下游产品

CAS号55-22-1 异烟酸 | CAS号14254-57-0 异烟酸酰氯 | CAS号54-85-3 异烟肼 | CAS号54401-85-3 4-吡啶乙酸乙酯 | CAS号3731-53-1 4-甲氨基吡啶 | CAS号586-95-8 4-吡啶甲醇 | CAS号14397-24-1 4-Pyridinecarbo... | CAS号14254-57-0 异烟酸酰氯 | CAS号41538-36-7 4-(4-氟苯(甲)酰)吡啶 | CAS号4329-75-3 1,2-二异烟酰基肼 | CAS号2110-30-7 6-bromo-2-pyrid... | CAS号1903-65-7 N-乙基哌啶-4-羧酰胺

异烟酸置于氯化亚砜体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 0.5H,以98%的收率获得氯化异氰盐酸盐
参考文献:一种合成异烟酸和吡啶甲酸活性酯的简单方法
标题:一种合成异烟酸和吡啶甲酸活性酯的简单方法
摘要:报道了从相应的酸制备异烟酸和吡啶甲酸的对硝基苯基-,N-羟基琥珀酰亚胺基-和五氟苯基酯的方法.
Doi:10.3390/60100047

专利信息

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A2
优先权日:1998-07-25
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:US-2009227575-A1
优先权日:2008-03-04
标 题 :7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS
发明人：VENKATESAN ARANAPAKAM MUDUMBAI; CHEN ZECHENG; DOS SANTOS OSVALDO; BROOIJMANS NATASJA; GOPALSAMY ARIAMALA
权利人:WYETH CORP
摘要:A 7H-pyrrolo[2,3-h]quinazoline compound of the formula I n n n n n n n n n n wherein Ar, R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , and n are as defined in the specification, and methods for making same.

专利号:US-6448443-B1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:US-5521179-A
优先权日:1991-04-18
标题 :Heterocyclic amides
发明人：BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.