CAS: 41365-75-7; 1-Amino-3,3-Diethoxypropane

相似化合物

6346-09-4 5754-35-8 16851-30-2

上下游产品

3-Azido-1,1-Diethoxypropane 688317-69-3
3,3-二乙氧基丙酰胺 3,3-Diethoxypropionic Amide 41365-74-6
3-硝基丙醛二乙缩醛 3-Nitropropanal Diethyl Acetal 107833-73-8
3-氯丙醛二乙醇缩醛 3-Chloro-1,1-Diethoxy-Propane 35573-93-4
氰基乙醛缩二乙醇 3,3-Bis(Ethyloxy)Propanenitrile 2032-34-0

3-氯丙醛二乙醇缩醛置于肼体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 7.0H,反应生成 1-氨基-3,3-二乙氧基丙烷
参考文献:萘啶酮衍生物的合成作为潜在的抗疟药
标题:萘啶酮衍生物的合成作为潜在的抗疟药
摘要:在本文中,我们介绍了8-(4'-氨基-1'甲基-丁基氨基)-5-(β,β,β-三氟乙氧基)-1,6-萘啶(4),8-(4'-氨基-1'甲基丁基氨基)-6-甲基-1,6-萘基甲基-5-一个(5),两个1-烷基-3-(4'-氨基-1'-甲基丁基氨基)-7-甲基-1,8-萘啶-4-酮(20A)和20B),3-(1'-氨基-4'-甲基丁基-氨基)-1-乙基-7-甲基-1,8-萘啶-4-酮(20C),和4-(4'-二乙基氨基-1'-甲基丁基氨基)-7-甲基-1,7-萘啶-8-一(28).在伯氏疟原虫筛查中评估了化合物的抗疟活性,发现该化合物无活性.
DOI:10.1002/jhet.5570180519

专利信息

专利号:US-5576426-A
优先权日:1988-08-30
标 题:Aldolase catalyzed stereoselective synthesis of arabinohexulose, xyloheptulose, threohexulose and xylohexulose
发明人：WONG CHI-HUEY; DURRWACHTER JOHN R; PEDERSON RICHARD L
权利人:SEARLE & CO
摘要:The present invention relates to aldolase catalyzed stereo-selective synthesis of sugars and compositions of matter comprising arabinohexulose, xyloheptulose, threohexulose, and xylohexulose.

专利号:US-5280126-A
优先权日:1988-02-22
标题 :Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2-methyl-1-oxopropyl]-Y-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

专利号:US-5216174-A
优先权日:1988-02-22
标题:Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3carboxamide by a novel synthesis where 4-methyl-3-oxoN-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1Hpyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

专利号:US-5097045-A
优先权日:1989-02-01
标题 :Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

专利号:US-5149837-A
优先权日:1988-02-22
标题 :Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluoro-phenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

专利号:US-5124482-A
优先权日:1988-02-22
标题:Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.