专利号:US-2010160670-A1 优先权日:2002-12-20 标 题 :Novel process for the preparation of chiral compounds derived from hexanoic acid esters and intermediates used in the synthesis of chiral-2-(bromomethyl)-2-ethylhexanoic acid 发明人:CROCQ-STUERGA VERONIQUE; ROUSSEL PATRICK 权利人:AVENTIS PHARMA SA 摘要:The present invention comprises a novel process for the preparation of a chiral compound of formula (I) n n n n n n n n n n wherein R 1 is hydroxyl or a group which activates the carboxyl and R 2 is alkyl optionally substituted by halogen or benzyl, its preparation, its application in the synthesis of chiral 2-bromomethyl-2-ethylhexanoic acid and novel intermediates.
专利号:US-2005240037-A1 优先权日:2002-07-23 标 题 :Method for the continuous intermediate separation of the solvent used in the oxirane synthesis with no coupling product 发明人:BASSLER PETER; GOBBEL HANS-GEORG; TELES JOAQUIN H; RUDOLF PETER 权利人:BASF AG 摘要:Process for the continuously operated distillation of the solvent used in the synthesis of an oxirane by reaction of a hydroperoxide with an organic compound, wherein the mixture comprising the solvent which is obtained in the synthesis and subsequent work-up is separated in a dividing wall column into a low-boiling fraction, an intermediate-boiling fraction and a high-boiling fraction and the solvent is taken off as intermediate-boiling fraction from the side offtake of the column.
专利号:US-6872727-B1 优先权日:1999-08-26 标 题:Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation 发明人:HERRMANN KONRAD; LEISTNER SIEGFRIED; WIPPICH PETRA 权利人:PRIVATES INST FUR BIOMEDIZINIS 摘要:Polycyclic pyrimidine-2,4(1H,3H)-diones with functionalized alkyl residues at the 1-, the 3-, or both position(s); methods for their synthesis, production, and pharmaceutical preparation. The invention concerns the synthesis of the above-described compounds, their chemical and structural characterization, and the analysis of their physiological/pharmacological activities in vitro and in vivo. These goals have been attained by the specification of routes of synthesis, methods for the production of the compounds, and the presentation of compound-specific characteristics. The substances encompassed by the present invention demonstrate pharmacologically significant collangenase/matrix metalloproteinase inhibitory activities. The specific example 1-(3-mercaptoprop-1-yl)-3-methyl-chinazolin-2,4(1H,3H)-dione will be presented in detail.
专利号:US-2024199658-A1 优先权日:2022-12-01 标 题:Direct synthesis of organotin alkoxides 发明人:JILEK ROBERT E; REED CHRISTOPHER J; NOVAS BRYAN 权利人:INPRIA CORP 摘要:Synthesis techniques are described for forming organotin trialkoxide compounds via direct alkylation of tin alkoxides. A first method involves reacting an alkali metal tin trialkoxide with an organohalide compound (RXn, where X is a halide atom and n≥1) to form a monoorgano tin trialkoxide represented by the formula R[Sn(OR′)3]n. The method can be used to form polytin trialkoxide compounds with a plurality of radiation sensitive C—Sn bonds. R and R′ include organo groups and can optionally comprise hetero-atoms and/or unsaturated bonds. A second method involves the ultraviolet light-driven reaction of a di-tin tetraalkoxide with an organohalide compound (RX) to form a monoorgano trialkoxide represented by the formula RSn(OR′)3. A third method involves the visible or ultraviolet light-driven reaction of a di-tin tetraalkoxide or an alkali metal tin trialkoxide with an fluorinated organohalide compound (RFX) to form a fluorinated monoorgano trialkoxide represented by the formula RFSn(OR′)3. The disclosed methods provide for high mono-organo specificity. Corresponding organotin trialkoxide compositions are also described. The compositions are useful for radiation patterning, especially with EUV radiation. The organotin trialkoxide compositions may be formed as radiation-patternable coatings on substrates.
专利号:US-4412079-A 优先权日:1968-03-13 标题:Thiadiazole compounds and methods of using said compounds in agriculture 发明人:CEBALO TONY; WALDE ROBERT A 权利人:AIR PROD & CHEM 摘要:Novel thiadiazole compounds are disclosed which contain in the 5 position, C-linked moieties which are either acyclic hydrocarbon radicals or halogenated acyclic hydrocarbon radicals (in which case each halogen is independently selected from F, Cl and Br). These novel compounds also contain an exocyclic nitrogen in the 2 position, and some of them contain the exocyclic substituent: wherein R3 is a lower acyclic hydrocarbon radical and R4 is either H or a lower acyclic hydrocarbon radical. Synthesis of these compounds is disclosed, including synthesis of those which exhibit isomerism and/or tautomerism. Various of these compounds have various agricultural utilities (e.g. as herbicides, insecticides, acaricides and fungicides), each of them having at least one such biological utility. Methods of using these compounds in phytotoxic fungicidal, acaricidal and insecticidal applications are disclosed.
专利号:WO-0046211-A1 优先权日:1999-02-04 标题:Method of synthesizing barbituric acid derivatives and their use for the synthesis of chemical libraries 发明人:MJALLI ADNAN M M 权利人:TRANSTECH PHARMA; MJALLI ADNAN M M 摘要:A support template of Formula (1).