专利号:US-2024336586-A1 优先权日:2021-07-29 标题:Methods for synthesis of racemic, scalemic, and chiral alpha-tocotrienol quinone 发明人:GIANNOUSIS PETER; MOLLARD PAUL; GOUDEDRANCHE SEBASTIEN; KARASAWA TOMOYA 权利人:PTC THERAPEUTICS INC 摘要:The application discloses methods useful for the synthesis of racemic, scalemic, and chiral alpha-tocotrienol quinone, including synthetic intermediates and methods for making said synthetic intermediates.
专利号:EP-2465936-A1 优先权日:2010-12-20 标题 :Enzymatic synthesis of statins and intermediates thereof 权利人:LEK PHARMACEUTICALS 摘要:The present invention discloses a process for preparing an active pharmaceutical ingredient (API) or intermediates thereof, notably particular step in the synthesis of an intermdiate useful for example in the preparation of statins, by using an enzyme capable of catalyzing oxidation or dehydrogenation. The invention further provides an expression system effectively translating said enzyme. In addition, the invention relates to a specific use of such enzyme for preparing API or intermediate thereof, and in particular for preparing statin or interemediate thereof.
专利号:US-6955904-B2 优先权日:2001-11-29 标 题:Gene coding for quinone oxidoreductase of kluyveromyces marxianus and protein expressed therefrom 发明人:HAN YE SUN; KOH HUN YEOUNG; RHIM HYEWHON; CHA JOO HWAN; KIM WOOK HYUN; BACK JUNG HO 权利人:KOREA INST SCI & TECH 摘要:The invention is a gene coding for a quinone oxidoreductase from Kluyveromyces marxianus and a protein having an amino acid sequence expressed therefrom, which can be advantageously used in a reduction reaction of a quinone compound and synthesis of intermediates for a biologically active compound.
专利号:US-2009093521-A1 优先权日:2005-06-14 标 题 :2, 5-Bis-Diamine [1,4] Benzoquinone-Derivatives 发明人:BOLOGNESI MARIA LAURA; BANZI RITA; MINARINI ANNA; MELCHIORRE CARLO 权利人:BOLOGNESI MARIA LAURA; BANZI RITA; MINARINI ANNA; MELCHIORRE CARLO 摘要:Synthesis of 2,5-bis-diamine-[1,4]benzoquinonic derivatives having the general formula (I), products and intermediates of said synthesis; the synthesis involves the use of p-benzoquinones having the general formula (IX) and diamines having the general formula (XI).
专利号:WO-2020185896-A1 优先权日:2019-03-11 标题 :Methods for processing and storing dna encoding formats of information 发明人:LEE HENRY HUNG-YI; HENRY OLIVIER Y F 权利人:HARVARD COLLEGE 摘要:The present disclosure provides methods for selectively tagging a subset of polynucleotide sequences from a plurality of polynucleotides comprising (a) synthesizing a plurality of polynucleotide sequences by flexible-write synthesis on a solid support, (b) selectively releasing a subset of polynucleotide sequences from the plurality of synthesized polynucleotides, and (c) tagging the released subset of polynucleotide sequences.
专利号:US-7674934-B2 优先权日:2004-08-05 标题:Stabilizers for use in NVP synthesis 发明人:HOEFER FRANK; BRAND ALEXANDRA; BOETTCHER ARND; BAUMANN KATRIN; VOGELSANG REGINA 权利人:BASF AG 摘要:A process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst, wherein the reaction is carried out in the presence of at least one stabilizer, and the use of stabilizers for increasing the selectivity in a process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst.
[参考文献]: Marilyn P Merker, Et Al. Influence Of Pulmonary Arterial Endothelial Cells On Quinone Redox Status: Effect Of Hyperoxia-Induced Nad(P)H:Quinone Oxidoreductase 1. Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L607-19. [参考文献]: Marilyn P Merker, Et Al. Role Of Mitochondrial Electron Transport Complex I In Coenzyme Q1 Reduction By Intact Pulmonary Arterial Endothelial Cells And The Effect Of Hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L809-19. [参考文献]: Michael Weber, Et Al. Method Development In Quantitative Nmr Towards Metrologically Traceable Organic Certified Reference Materials Used As (31)P Qnmr Standards. Anal Bioanal Chem. 2015 Apr;407(11):3115-23. [参考文献]: Michael Weber, Et Al. Using High-Performance 1H Nmr (Hp-Qnmr) For The Certification Of Organic Reference Materials Under Accreditation Guidelines--Describing The Overall Process With Focus On Homogeneity And Stability Assessment. J Pharm Biomed Anal. 2014 May:93:102-10. [参考文献]: Roger Giordani, Et Al. Evidence For Two Different Electron Transfer Pathways In The Same Enzyme, Nitrate Reductase A From Escherichia Coli. Eur J Biochem. 2004 Jun;271(12):2400-7.
合成参考文献
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