CAS: 701-27-9; 3-Fluorobenzenesulfonyl Chloride

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CAS号372-19-0 3-氟苯胺 | CAS号768-35-4 3-氟苯基硼酸 | CAS号7217-41-6 (3-fluorophenyl... | CAS号2557-77-9 3-氟苯硫酚 | CAS号625-98-9 间氯氟苯 | CAS号61081-29-6 2-(3-fluorophen...

3-氯氟苯 反应生成 3-氟苯磺酰氯
参考文献:间位取代氟苯中的氟核磁共振屏蔽.溶剂对归纳顺序的影响
标题:间位取代氟苯中的氟核磁共振屏蔽.溶剂对归纳顺序的影响
摘要:摘要 : 21 种间位取代氟苯相对于固定外标和相对于氟苯作为内标的 F-19 NMR 屏蔽参数是在室温下在 20 种广泛变化的纯溶剂中高稀释下获得的.还对非极性和羟基溶剂(纯溶剂和混合溶剂)中的 24 个附加取代基进行了广泛的测量.尽管相对于固定的外部标准,给定氟苯的屏蔽变化超过 9.2 Ppm,但相对于内部氟苯具有化学惰性间位取代基的七种化合物的屏蔽参数是溶剂不变的,其精度与实验误差相同.该结果提供了关键证据,即 F 原子与溶剂相互作用导致的分子间屏蔽对间位取代氟苯相对于作为内标的氟苯的屏蔽参数贡献很小或没有贡献.进一步的结论是,场效应对由于间位(可能是对位)取代基引起的屏蔽变化没有实际贡献.进一步暗示,对于许多非质子溶剂在室温下,基团的键偶极矩与介电常数的这种变化的非常好精度无关.溶剂对具有化学活性取代基的间位取代氟苯的屏蔽参数的影响归因于电荷转移溶剂-取代基相互作用.(作者)进一步的结
DOI:10.1021/ja00889A015

专利信息

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-10246411-B2
优先权日:2014-10-29
标 题:(Z)-3,4,5-trimethoxystyrylbenzenesulfonamides as potential anticancer agents
发明人：KAMAL AHMED; RASALA MAHESH; RATNA REDDY CHALLA; BHARATH KUMAR GAJJELA; SASTRY VISWESWARA; BASHA SHAIK ANVER; SANTHOSH REEDY VANGALA
权利人:COUNCIL SCIENT IND RES
摘要:This present invention relates to (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides of general formula A. The invention also provides the synthesis of (Z)-3,4,5-trimethoxystyrylbenzenesulfonamides useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof.

专利号:CN-117720498-A
优先权日:2023-11-03
标 题 :Synthesis of a new coumarin derivative containing a sulfonamide fragment and preparation method and application of its composition

专利号:JP-2010222357-A
优先权日:2002-03-11
标题 :Intermediate compounds for the synthesis of aminoindazole derivatives

专利号:CN-119320374-A
优先权日:2024-11-04
标 题 :A method for photocatalytic synthesis of 3-sulfonyl-substituted chromone derivatives