CAS: 79-46-9; 2-Nitropropane

上下游产品

2-iodo-propane i-propyl nitrite propane Isobutane 1,1-Dimethyl-1-nitro-2-piperidinoethan 4-(2-methyl-2-nitropropyl)morpholine 4-methyl-4-nitro-3-phenylpentanal 2-nitro-2-nitrosopropane

丙烷置于n-羟基邻苯二甲酰亚胺,Air,二氧化氮体系中,用 Various Solvent(S) 作为反应溶剂,100.0 °C,506.66 Kpa 条件下,反应 14.0H,以65%的收率获得产物2-硝基丙烷
参考文献:N-羟基邻苯二甲酰亚胺催化的二氧化氮和硝酸有效地将轻链烷烃和芳香族化合物的烷基侧链硝化.
标题:N-羟基邻苯二甲酰亚胺催化的二氧化氮和硝酸有效地将轻链烷烃和芳香族化合物的烷基侧链硝化.
摘要:通过在相对温和的条件下使用n-羟基邻苯二甲酰亚胺(nhpi)作为催化剂,成功实现了轻链烷烃和芳香族化合物与no(2)和hno(3)的烷基侧链的硝化.例如,在100摄氏度下,Nhpi催化的no(2)硝化丙烷14小时,可以得到高产率的2-硝基丙烷,而不会形成1-硝基丙烷和裂解产物,例如硝基乙烷和硝基甲烷.通过使用nhpi作为关键催化剂,可以通过本发明的方法选择性地获得通过常规方法难以制备的各种脂肪族硝基烷.另外,选择性地进行烷基苯如甲苯的侧链硝化以产生α-硝基甲苯而不进行环硝化.
DOI:10.1021/jo025632D

专利信息

专利号:US-5442065-A
优先权日:1993-09-09
标 题:Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin
发明人：MAGNUS PHILIP D; ILIADIS THEODORE; EISENBEIS SHANE A; FAIRHURST ROBIN A
权利人:UNIV TEXAS
摘要:A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of the antitumor antibiotic dynemicin. The synthesis allows efficient production of the enediyne as a stable, compound in good yield from the adamantyl N-protected azabicyclo[7.3.1]tridecadiyne. The adamantyl protecting group is employed in the starting material, N-adamantyl dihydroquinoline or N-adamantyl 6-methoxy quinoline. Also disclosed are process for the synthesis of 3-hydroxy-6-methoxyquinoline and several N-substituted derivatives of azobicyclo[7.3.1]tridecaenediyne. Solid tumor and leukemia assays were performed on the analogs of dynemicin. The results suggest a method that these compounds will useful in treating certain types of leukemias and solid tumors. The disclosed synthesis provides a route to new dynemicin intermediates and analogs which will allow development of second and third generation dynemicins.

专利号:US-10633360-B2
优先权日:2014-12-23
标题 :Efficient process for the synthesis of alkoxy substituted benzaldehydes
发明人：MOHAPATRA Manoj Kumar; BENDAPUDI Ramamohanrao; MENACHERRY Paul Vincent; PAUL VINCENT
权利人:ANTHEA AROMATICS PRIVATE LTD
摘要:The present invention relates to the synthesis of alkoxy substituted benzaldehydes obtained from the corresponding alkoxy substituted benzenes. Alkoxy substituted benzaldehydes are products of broad commercial interest and are used as end products and intermediates in flavor and fragrance applications and pharmaceutical ingredients. For example, 3,4-methylendioxy-benzaldehyde (also known as heliotropin or piperonal) is used widely both as a end product and intermediate for the above mentioned applications. Other examples include 3,4-dimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde and 3,4-ethylenedioxybenzene which are intermediates in the synthesis of active pharmaceutical intermediates.

专利号:US-4219489-A
优先权日:1978-09-05
标题:Synthesis of steroids
发明人：BUNES LEONARD A; JOHNSON WILLIAM S
权利人:STANFORD LELAND JUNIOR UNIV TR
摘要:Method and compounds are provided for use in the synthesis of steroids wherein a polyolefin is provided having an initiating group having a chalcogen atom in juxtaposition to a double bond, so as to be capable of bond formation to close to form a ring and having a terminating group involving pi unsaturation (a double or triple bond) conjugated to an aromatic ring. Upon acid catalysis, sigma bonds are formed through the interaction of a carbocation formed at the carbon atom bonded to the chalcogen atom and the double bond intermediate the initiating group and the terminating group, which close to form rings of a steroid nucleus, the carbocation interacting with the pi unsaturation conjugated with the aromatic group and being captured by a nucleophile present in the acidic reaction medium. The resulting steroid product may then be modified in known ways to produce known steroids.

专利号:US-12281398-B2
优先权日:2022-02-07
标题:Microfluidic process for the general electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds
发明人：SCHROER THORSTEN G; LECROY GREGORY E; AGUILA MIGUEL; RODRIGUEZ MAYRA P; DOWNARD TYLER J; MACLEOD BRIANNA L
权利人:US GOV AIR FORCE; US AIR FORCE
摘要:A process for the microfluidic electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds comprising the steps ofpumping a solution comprising a compound of Formula Iinto a microfluidic electrochemical reactor in the presence of a base, one of a halide or pseudohalide salt (MY), and a mediator;applying an electrical current through the microfluidic electrochemical reactor; andperforming oxidative addition to create a geminal dipseudohalide or halide-pseudohalide compound of the general Formula II

专利号:US-3884945-A
优先权日:1973-04-26
标题 :Synthesis of steroids by cyclization in nitro solvents
发明人：JOHNSON WILLIAM S; MORTON DOUGLAS R; GRAVESTOCK MICHAEL B
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Synthesis of steroids by cyclization of a dienyne cyclization substrate to a steroid or A-nor steroid employing a primary or secondary aliphatic nitro compound as solvent, thereby forming an oxime ether group at the C-17 position of the resulting steroid (or at the corresponding position of the resulting A-nor steroid where that is the product of cyclization). This oxime group can be converted to an hydroxy group by reductive cleavage. Conversion of the cyclization products to steroids such as 17hydroxypregnan-20-ones and testosterone is facilitated. The method is also applied to cyclization of suitable substrates to bicyclic products.

专利号:US-4866175-A
优先权日:1966-11-08
标 题 :Novel process for the synthesis of quinoxaline and benzimidazole-N-oxides
发明人：ISSIDORIDES COSTAS H; HADDADIN MAKHLUF J
权利人:RESEARCH CORP
摘要:The synthesis of quinoxaline and benzimidazole-N-oxides and of ester amd amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a movel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.