CAS: 874-86-2; 4-(Chloromethyl)Benzonitrile

上下游产品

CAS号17201-43-3 α-溴对甲基苯甲腈 | CAS号10406-25-4 4-氰基苯甲胺 | CAS号107-06-2 1,2-二氯乙烷 | CAS号104-85-8 对甲苯腈 | CAS号7782-50-5 氯气 | CAS号37812-51-4 4-(4-吗啉基甲基)苯腈 | CAS号5462-71-5 4-氰基-苯乙酸 | CAS号60710-80-7 3-氨基-4-甲基苯腈 | CAS号6068-72-0 4-氰基苯甲酰氯 | CAS号501-89-3 4-羧基苯乙酸 | CAS号51359-78-5 4-溴甲基苯甲醛 | CAS号21388-95-4 (4-cyanophenyl)... | CAS号34403-48-0 N-甲基-4-氰基苄胺 | CAS号3006-96-0 4-羟甲基苯甲酸 | CAS号55255-64-6 4,4'-[Oxybis(me...

对甲苯腈置于三氟甲烷磺酰氯,Iron(Iii) Chloride Hexahydrate体系中,用 乙腈 作为反应溶剂,以74 %的收率获得产物对氰基氯苄
参考文献:光诱导 Fecl3 催化三氟甲磺酰氯选择性苄基 C−h 氯化
标题:光诱导 Fecl3 催化三氟甲磺酰氯选择性苄基 C−h 氯化
摘要:在这里,我们报道了一种光诱导fecl 3催化的苄基c−h氯化方法,具有显着的区域选择性,使得烷基苯能够在温和条件下使用三氟甲磺酰氯(Tfcl)作为氯源转化为多功能的苄基氯.dft 计算表明,使用 Tfcl 时,苄基 α−c−h 氯化的动力学偏好更加明显.
DOI:10.1002/adsc.202300672

专利信息

专利号:US-7705159-B2
优先权日:2005-07-06
标题:Process for the preparation of letrozole
发明人：MACDONALD PETER LINDSAY; BIGATTI ETTORE; ROSSETTO PIERLUIGI; HAREL ZVI
权利人:SICOR INC
摘要:The invention provides a high-yield process for the preparation of letrozole having a high purity, without the need for removal of the 4-[1-(1,3,4-triazolyl)methyl]benzonitrile impurity at the intermediate stage. The invention also provides a process for the synthesis of letrozole in which formation of the impurity 4-[1-(1,3,4-triazolyl)methyl]benzonitrile during the first stage is minimized. In the process, a 4-(halomethyl)benzonitrile is reacted with a salt of 1H-1,2,4-triazole, reducing the formation of the impurity. Preferably, the preparation is conducted as a one-pot process.

专利号:US-8003804-B2
优先权日:2006-03-17
标题:Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate
发明人：PATHI SRINIVAS LAXMINARAYAN; KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA; VASANT CHIKHALIKAR SANDIP
权利人:CIPLA LTD
摘要:The present invention relates to a process for the preparation of 4-[1-(4-cyano phenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile (letrozole), substantially free from its isomeric impurity. The preparation involves reaction of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile with 4-fluorobenzonitrile in the presence of an organic solvent and a silicon amine. The present invention also relates to a process for the preparation of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile which involves: (a) the reaction of a 4-halomethyl benzonitrile with 1,2,4-triazole in the presence of cesium carbonate and an organic solvent to obtain a reaction mass comprising 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile of formula II; and (b) precipitation of 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile (II) from the reaction mass using a suitable organic solvent.

专利号:WO-2013035102-A1
优先权日:2011-09-05
标 题 :Processes for the preparation of imatinib base and intermediates thereof
发明人：KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD; KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
摘要:The invention relates to an improved process for the preparation of highly pure imatinib base (99.99% HPLC purity) of formula (I) and the pharmaceutically acceptable acid addition salts thereof. This invention also relates to processes for the preparation of the intermediates in the synthesis of imatinib base.

专利号:EP-1326851-B1
优先权日:2000-10-13
标 题 :Substituted dipeptides as growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-4603209-A
优先权日:1984-09-07
标题 :Fluorescent indicator dyes for calcium ions
发明人：TSIEN ROGER Y; GRYNKIEWICZ GRZEGORZ
权利人:UNIV CALIFORNIA
摘要:The present invention discloses a new class of highly fluorescent indicator dyes that are specific for calcium ions. The new fluorescent indicator dyes combine a stilbene-type fluorophore with a tetracarboxylate parent Ca 2+ chelating compound having the octacoordinate pattern of liganding groups characteristic of EGTA and BAPTA. Preferred forms contain extra heterocyclic bridges to reinforce the ethylenic bond of the stilbene and to reduce hydrophobicity. Compared to their widely used predecessor, 'quin2', the new dyes offer up to thirty-fold brighter fluorescence, major changes in wavelength (not just intensity) upon Ca 2+ binding, slightly lower affinities for Ca 2+ , slightly longer wavelengths of excitation, and considerably improved selectivity for Ca 2+ over other divalent cations. These properties, particularly the wavelength sensitivity to Ca 2+ , make the dyes useful indicators for many intracellular applications, especially in single cells, adherent cell layers, or bulk tissues. n The present invention also discloses an improved method for synthesizing alpha-acyloxyalkyl bromides wherein the bromides so synthesized are free of contaminating bis(1-bromoalkyl)ether. The improved method is exemplified herein in the synthesis of acetoxymethyl bromide, a compound useful in preparing the acetoxymethyl esters disclosed herein as novel Ca 2+ specific fluorescent indicators.

专利号:CN-107602415-A
优先权日:2017-09-25
标 题:A kind of Fe(â…¢) porphyrin-catalyzed method for the one-pot synthesis of aromatic nitriles by oxidizing aromatic olefins with nitrite