CAS: 90098-04-7; 2-(4-Chlorobenzamido)-3-(2-Oxo-1,2-Dihydroquinolin-4-yl)Propanoic Acid

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CAS号122-01-0 4-氯苯甲酰氯 | CAS号4876-14-6 2-氨基-3-(2-氧代-1,... | CAS号64-17-5 乙醇 | CAS号4876-10-2 4-溴甲基喹啉-2-酮 | CAS号81918-01-6 4-氯苯甲酰氨基丙二酸二乙酯 | CAS号4900-38-3 2-乙酰氨基-2-((2-氧代...

4-氯苯甲酰氯置于ammonium Hydroxide,硫酸,Sodium Carbonate体系中,化学反应 79.5H,反应生成 瑞巴派特
参考文献:一种瑞巴派特的合成工艺
标题:一种瑞巴派特的合成工艺
摘要:本发明公开了一种瑞巴派特的合成工艺,具体合成过程如下:将氨水加入反应容器中,然后逐滴向其中滴入4‑氯苯甲酰氯,得到4‑氯苯甲酰氨;将进行格式反应后与甲酸反应制备产物1;将产物1,进行加成反应得到产物2;然后将产物2氯代后与4‑氯苯甲酰氨反应得到产物3;将产物3加入反应容器中,然后向其中加入质量分数为60%的硫酸溶液,加热至80oc搅拌反应3H,得到产物2‑(4‑氯苯甲酰胺基)‑3‑[2(1H)‑喹啉酮‑4]丙酸.本发明的合成过程中通过格式反应,亲核加成和取代反应制备,生产成本低,并且得到产物的产率高,合成条件简单,可以适用于大规模生产.

专利信息

专利号:WO-2024074814-A9
优先权日:2022-10-04
标题 :Composition comprising a functionalised dye and a diallylamine comonomer and use thereof
发明人：CANNON PAUL; DONLEY ADAM; LAWRENCE ANTHONY; WRIGHT GAVIN; TURNER CARL; ROBERTS PHILIP
权利人:SUBLINO LTD; COLOUR SYNTHESIS SOLUTIONS LTD
摘要:The present teachings relate to a composition comprising a functionalised dye and a diallylamine comonomer, and the use of such compositions in methods of colouring a substrate. The present teachings provide improved bonding of a dye to a substrate, and preferably allow colouring to be conducted entirely in the presence of an aqueous solvent.

专利号:CN-108503582-A
优先权日:2018-01-19
标 题:Microwave Assisted Synthesis of 2-(1H)-Quinolinones

专利号:CN-105753781-A
优先权日:2016-04-06
标题 :A kind of green synthesis method of 4-bromomethyl quinolinone

专利号:CN-108276330-A
优先权日:2018-02-07
标题 :A kind of synthesis technology of Rebamipide

专利号:US-7371775-B2
优先权日:2003-09-04
标题:7-carboxymethyloxy-3′,4′,5-trimethoxy flavone monohydrate, the preparation method and uses thereof
发明人：YOO MOOHI; KIM DONG SUNG; KIM YONG DUCK; KIM WONBAE
权利人:DONG A PHARMACEUTICALS CO LTD
摘要:The present invention relates to 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone.monohydrate which is a non hygroscopic product suitable for the preparation of metered dose of 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone having protective activity for gastrointestinal tract including the colon, and a preparation method and uses thereof. 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone.monohydrate of the present invention has advantages such as mucus protecting activity for gastrointestinal tract including the colon, convenience for handling and storage under ordinary humidity owing to its non-hygroscopicity, and ability to contain an active compound consistently for the formulation production of a medicine. In addition, the preparation method of 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone.monohydrate of the present invention reduces long steps of total synthesis and requires mild conditions for the production of a compound because autoclave condition is not necessary for methylation in this case, and makes mass-production possible without any purification process such as recrystallization or column chromatography.

专利号:CN-105753781-B
优先权日:2016-04-06
标 题 :A kind of green synthesis method of 4 bromomethyl quinolinone