CAS: 1030825-20-7; 2-(5-Bromo-2-Methylbenzyl)-5-(4-Fluorophenyl)Thiophene

相似化合物

898566-17-1 2443502-91-6 1030825-20-7

上下游产品

CAS号1132832-75-7 (5-溴-2-甲基苯基)-(5... | CAS号460-00-4 对氟溴苯 | CAS号79669-49-1 2-甲基-5-溴苯甲酸 | CAS号58861-48-6 2-(4-氟苯基)噻吩 | CAS号21900-41-4 5-溴-2-甲氧基苄氯 | CAS号898566-17-1 2-(4-氟苯基)-5-((5...

2-甲基-5-硝基苯甲酰氯置于tris-(Dibenzylideneacetone)Dipalladium(0),亚硝酸异丁酯,Potassium Carbonate,Magnesium,Copper(I) Bromide,三环己基膦体系中,用 乙醇,水,丙酮 用作溶剂,化学反应 52.0H,反应生成2-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩
参考文献:2-(4-氟苯基)-5-[(5-溴-2-甲基苯基)甲基]噻 吩的制备方法
标题:2-(4-氟苯基)-5-[(5-溴-2-甲基苯基)甲基]噻 吩的制备方法
摘要:本发明公开了一种2-(4-氟苯基)-5-[(5-溴-2-甲基苯基)甲基]噻吩的制备方法,由5-硝基-2-甲基-苯甲酰氯经5-溴噻吩-2-硼酸和4-氟苯硼酸经两次铃木交叉偶联反应,还原反应,桑德迈尔反应四步骤而得,属于药物中间体制备领域,可用于制备具有治疗ii型糖尿病作用的药物卡格列净.该法具有操作简单,工艺稳定,收率高,三废少,生产成本低,产品质量好的特点.

专利信息

专利号:WO-2017063617-A1
优先权日:2015-10-13
标 题 :Preparation of intermediates for the synthesis of canagliflozin and dapagliflozin
发明人：ZEZULA JOSEF; BABIAK PETR; HAJDUCH JAN
权利人:ZENTIVA KS
摘要:The present invention relates to a preparation method of the intermediates of structures la (for the synthesis of canagliflozin) and 1b (for the synthesis of dapagliflozin), where in structure la X is methyl and Ar represents 2-(5-(4-fluorophenyl)-thienyl) and in structure 1b X is chlorine and Ar represents 4-ethoxyphenyl.

专利号:EP-2918579-A1
优先权日:2014-03-14
标题 :Synthesis of 2-arylmethyl-5-aryl-thiophene
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 2-arylmethyl-5-aryl-thiophene, an intermediate in the synthesis of C-aryl glycosides.

专利号:WO-2015177083-A1
优先权日:2014-05-19
标题 :STEREOSELECTIVE SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ß-C-ARYLGLUCOSIDES
发明人：ZUPANCIC BORUT; SELIC LOVRO; CUSAK ANJA; RICHTER FRANK
权利人:LEK PHARMACEUTICALS
摘要:The invention belongs to the fields of pharmaceutical industry, and particularly to an improved stereoselective synthesis of intermediate compounds for the preparation of gliflozins, for example canagliflozin or structurally similar gliflozins. Gliflozins, such as canagliflozin, dapagliflozin, empagliflozin, or ipragliflozin, inhibit the sodium-dependent glucose cotransporter 2 (SGLT2) in the kidney and as such are useful in the treatment of type-2 diabetes.

专利号:EP-2947077-A1
优先权日:2014-05-19
标 题 :Stereoselective synthesis of intermediates in the preparation of ß-C-arylglucosides

专利号:CN-115260151-A
优先权日:2022-09-02
标 题:Synthesis process of canagliflozin impurity

专利号:CN-109336875-B
优先权日:2017-08-15
标 题:Synthesis method of canagliflozin