CAS: 106984-91-2; 6-Oxo-1,6-Dihydropyridine-3-Carbaldehyde

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CAS号65873-72-5 6-甲氧基-3-吡啶甲醛 | CAS号635712-99-1 6-(苄氧基)烟醛 | CAS号114951-44-9 3-pyridine carb... | CAS号114951-35-8 3-pyridinecarba... | CAS号624-28-2 2,5-二溴吡啶 | CAS号83664-33-9 2-苄氧基-5-溴吡啶 | CAS号109205-68-7 2-羟基-5-羟甲基吡啶

2,5-二溴吡啶置于正丁基锂,氢溴酸体系中,用 四氢呋喃,甲醇 用作溶剂,化学反应 20.0H,反应生成2-羟基吡啶-5-醛
参考文献:氮杂胸腺嘧啶衍生物的电化学氧化与阴离子氧化
标题:氮杂胸腺嘧啶衍生物的电化学氧化与阴离子氧化
摘要:Pymetrozine (1) 通过用氧捕获其二价阴离子,然后用亚铁盐还原,以低到中等产率转化为半胺 2.Pymetrozines 18 和 19 未能进行这种类型的氧化.所有三种吡蚜酮均在 C5 处被电化学氧化为甲基半胺 20,21 和 22.20 到 2 的水解在酸或碱催化条件下以优异的收率完成,而甲基半缩醛 21 和 22 的水解最好在碱性条件下进行.Pymetrozine 1,半胺类 2 和 3 的土壤代谢物以中等规模制备,产量极好.线性扫描伏安法数据和制备规模电化学条件是为前体吡蚜酮提供的.为所有新化合物提供完整的实验和光谱数据,并讨论了烷基酰胺的阴离子氧化与电化学氧化的相对优点.由于潜在的爆炸危险,对大规模阴离子氧化条件的描述提供了警告说明.
Doi:10.1021/ja9711122

专利信息

专利号:WO-2025128873-A1
优先权日:2023-12-12
标题:Heterocyclic pyridinone compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:CN-110563765-B
优先权日:2019-09-18
标 题:Synthesis method of Schiff base phosphazene double-base structure flame retardant and modified polyurethane flame retardant

专利号:CN-110563765-A
优先权日:2019-09-18
标 题 :Synthesis method of Schiff base phosphazene double base structure flame retardant and modified polyurethane flame retardant